Expression of TGF-Β receptor ALK-5 has a negative impact on outcome of patients with acute myeloid leukemia

Leukemia

Volumn 25, Issue 2, 2011, Pages 375-379

  Otten, J ^a   Schmitz, L ^a   Vettorazzi, E ^a   Schultze, A ^a   Marx, A H ^a   Simon, R ^a   Krauter, J ^b   Loges, S ^a   Sauter, G ^a   Bokemeyer, C ^a   Fiedler, W ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 9; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; BLOOD SAMPLING; DISEASE ASSOCIATION; FEMALE; GENE TARGETING; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REMISSION; SURVIVAL RATE;

EID: 79751518154     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.273     Document Type: Letter

References (6)

1. Otten J, Bokemeyer C, Fiedler W. Tgf-Beta superfamily receptorstargets for antiangiogenic therapy? J Oncol 2010; 2010: 317068.
2. Ayala F, Dewar R, Kieran M, Kalluri R. Contribution of bone microenvironment to leukemogenesis and leukemia progression. Leukemia 2009; 23: 2233-2241.
3. Goumans MJ, Valdimarsdottir G, Itoh S, Lebrin F, Larsson J, Mummery C et al. Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol Cell 2003; 12: 817-828. (Pubitemid 37352776)
4. David L, Mallet C, Mazerbourg S, Feige JJ, Bailly S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood 2007; 109: 1953-1961. (Pubitemid 46348192)
5. Shao ES, Lin L, Yao Y, Bostrom KI. Expression of vascular endothelial growth factor is coordinately regulated by the activinlike kinase receptors 1 and 5 in endothelial cells. Blood 2009; 114: 2197-2206.
6. Zhou L, Nguyen AN, Sohal D, Ying Ma J, Pahanish P, Gundabolu K et al. Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS. Blood 2008; 112: 3434-3443.