DNA-adducts in subjects exposed to urban air pollution by benzene and polycyclic aromatic hydrocarbons (PAHs) in Cotonou, Benin

Environmental Toxicology

Volumn 26, Issue 1, 2011, Pages 93-102

  Ayi Fanou, Lucie ^a   Avogbe, Patrice H ^a   Fayomi, Benjamin ^b   Keith, Gerard ^c   Hountondji, Codjo ^d   Creppy, Edmond E ^e   Autrup, Herman ^f   Rihn, Bertrand Henri ^g   Sanni, Ambaliou ^a  

^a FAST/UAC   (Benin)

^b Unité d'Enseignement et de Recherche au Travail et Environnement   (Benin)

^c INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d SORBONNE UNIVERSITÉ   (France)

^e UNIVERSITÉ DE BORDEAUX   (France)

^f AARHUS UNIVERSITY   (Denmark)

^g UNIVERSITÉ DE LORRAINE   (France)

Author keywords

32P postlabelling; Air pollution; Benzene; DNA adducts; Exposed and none exposed subjects; PAHs

Indexed keywords

32P POSTLABELLING; AIR POLLUTANTS; AIR POLLUTION EFFECTS; AMBIENT AIR; BENZO(A)PYRENE; CHRONIC DISEASE; CITY RESIDENTS; CONTROL GROUPS; DNA-ADDUCTS; ELEVATED LEVEL; EXPOSED AND NONE EXPOSED SUBJECTS; EXPOSURE LEVEL; GENETIC SUSCEPTIBILITY; GENOTOXIC COMPOUNDS; HEALTHY PEOPLE; PAHS; PUBLIC HEALTH; STREET FOODS; URBAN AIR POLLUTION;

AIR QUALITY; BENZENE; DNA; GASOLINE; HEALTH RISKS; NUCLEIC ACIDS; NUCLEOTIDES; ORGANIC COMPOUNDS; POLLUTION; PYRENE; ROADSIDES; TAXICABS;

AROMATIC HYDROCARBONS;

BENZENE; BENZO[A]PYRENE; PHOSPHORUS 32; POLYCYCLIC AROMATIC HYDROCARBON;

ATMOSPHERIC POLLUTION; BENZENE; DOSE-RESPONSE RELATIONSHIP; HEALTH RISK; PAH; POLLUTION EXPOSURE; PUBLIC HEALTH; URBAN ATMOSPHERE; URBAN POPULATION;

AIR POLLUTION; ARTICLE; AUTORADIOGRAPHY; BENIN; CONTROLLED STUDY; DNA ADDUCT; DRIVER; ENVIRONMENTAL EXPOSURE; HIGH RISK POPULATION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; URBAN AREA;

ADULT; AIR POLLUTANTS; AUTORADIOGRAPHY; BENIN; BENZENE; BENZO(A)PYRENE; BIOLOGICAL MARKERS; DNA ADDUCTS; ENVIRONMENTAL MONITORING; FEMALE; HUMANS; INHALATION EXPOSURE; MALE; POLYCYCLIC HYDROCARBONS, AROMATIC; RURAL POPULATION; URBAN POPULATION; VEHICLE EMISSIONS; YOUNG ADULT;

ATLANTIQUE; BENIN [WEST AFRICA]; COTONOU; GODOMEY; OUEME;

EID: 79751515111     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20533     Document Type: Article

References (33)

1. Arfellini G, Grilli S, Colacci A, Mazzullo M, Prodi G. 1985. In vivo and in vitro binding of benzene to nucleic acids and proteins of various rat and mouse organs. Cancer Lett 28: 159-168.
2. Autrup H, Daneshvar B, Dragsted LO, Gamborg M, Hansen AM, Loft S, Okkels H, Nielsen F, Nielsen PS, Raffn E, Wallin H. and Knudsen LE. 1999. Biomarkers for exposure to ambient air pollution-Comparision of carcinogen-DNA-adduct levels with other exposure markers and markers for oxidative stress. Environ Health Perspect 107: 3.
3. Avogbe PH, Ayi-Fanou L, Autrup H, Loft S, Fayomi B, Sanni A, Vinzents P, Moller P. 2005. Ultrafine particulate matter and high-level benzene urban air pollution in relation to oxidative DNA damage. Carcinogenesis 26: 613-620.
4. Ayi-Fanou L, Théophile AM, Creppy EE, Fayomi B, Fustoni S, MØller P, Kyrtopoulos S, Loft S, Sanni A, Skov H, Øvrebø S, Autrup H. 2006. Survey of air pollution in Cotonou-Benin- personal monitoring and biomarkers. Sci Total Environ 358: 85-96.
5. Begbee WL, Vincze I. 1999. Biomonitoring of human genotoxicity induced by complex occupational exposures. Mutat Res 445: 193-203.
6. Binet S, Bonnet P, Brandt H, Castegnaro M, Delsaut P, Fabries JF, Huynh CK, Lafontaine M, Morel G, Nunge H, Rihn B, Vu Duc T, Wrobel R. 2002. Development and validation of a new bitumen fume generation system which generates polycyclic aromatic hydrocarbon concentrations proportional to fume concentrations. Ann Occup Hyg 46: 617-628.
7. Binkova B, Chvatalova I, Lnenickova Z, Milcova A, Tulupova E, Peter B, Farmer PB, Sram RJ. 2007. PAH-DNA adducts in environmentally exposed population in relation to metabolic and DNA repair gene polymorphisms. Mutat Res 620: 49-61.
8. Bottin MC, Gate L, Rihn B, Micillino JC, Nathalie M, Martin A, Nunge H, Morel G, Wrobel R, Ayi-Fanou L, Champmartin C, Keith G, Binet S. 2006. Genotoxic effects of bitumen fumes in Big Blue transgenic rat lung. Mutat Res 596: 91-105.
9. Collins AR. 1999. Oxidative DNA damage, antioxidants, and cancer. Bioessays 21: 238-246.
10. Farmer PB, Singh R, Kaur B, Sram RJ, Binkova B, Kalina I, Popov TA, Garte S, Taioli E, Gabelova A, Cebulska-Wasilewska A. 2003. Molecular epidemiology studies of carcinogenic environmental pollutants. Effects of polycyclic aromatic hydrocarbons (PAHs) in environmental pollution on exogenous and oxidative DNA damage. Mutat Res 544: 397-402.
11. Garte S, Taioli E, Raimondi S, Paracchini V, Binkova B, Sram RJ, Kalina I, Popov TA, Singh R, Farmer PB. 2007. Effects of metabolic genotypes on intermediary biomarkers in subjects exposed to PAHS: Results from the EXPAH study. Mutat Res 620: 7-15.
12. Georgiadis P, Topinka J, Stoikidou M, Kaila S, Gioka M, Katsouyanni K, Sram RG, Autrup H, Kyrtopoulos SA. 2001. Biomarkers of genotoxicity of air pollution (the AULIS project): Bulky DNA adducts in subjects with moderate to low exposures to airbone polycyclic aromatic hydrocarbons and their relationship to environmental tobacco smoke and other parameters. Carcinogenesis 22: 1447-1457.
13. Katsouyanni K, Pershagen G. 1997. Ambient air pollution exposure and cancer. Cancer Causes Control 8: 289-291.
14. Keith G, Dirheimer G. 1995. Postlabeling: A sensitive method for studying DNA adducts and their role in carcinogenesis. Curr Opin Biotehnol 6: 3-11.
15. Kuljukka-Rabb T, Nylund L, Vaaranrinta R, Savela K, Mutanen P, Veidebaum T, Sorsa M, Rannug A, Peltonen K. 2002. The effect of relevant genotypes on PAH exposure-related biomarkers. J Expo Anal Environ Epidemiol 12: 81-91.
16. Micillino JC, Coulais C, Binet S, Bottin MC, Keith G, Moulin D, Rihn BH. 2002. Lack of genotoxicity of bitumen fumes in transgenic mouse lung. Toxicology 170: 11-20.
17. Morello-Frosch RA, Woodruff TJ, Axelrad DA, Caldwell JC. 2000. Air toxics and health risks in California: The public health implications of outdoor concentrations. Risk Anal 20: 273-291.
18. Nielsen PS, Andreassen A, Moller P, Farmer B, Overbo S, Autrup H, Biomonitoring of diesel exhaust exposed workers. 1996a. DNA and haemoglobin adducts and urinary 1-hydroxypyren as markers of exposure. Toxicol Lett 86: 27-37.
19. Nielsen PS, de Pater N, Okkels H, Autrup H. 1996b. Environmental air pollution and DNA adducts in Copenhagen bus drivers-Effects of GSTM1 and NAT2 genotypes on adducts levels. Carcinogenesis 17: 1021-1027.
20. Peluso M, Neri M, Margarino G, Mereu C, Munnia A, Ceppi M, Buratti M, Felletti R, Stea F, Quaglia R, Puntoni R, Taioli E, Garte S, Bonassi S. 2004. Comparison of DNA adduct levels in nasal mucosa, lymphocytes and bronchial mucosa of cigarette smokers and interaction with metabolic gene polymorphisms. Carcinogenesis 25: 2459-2465.
21. Phillips DH, Castegnaro M. 1999. Standardization and validation of DNA-adduct postalbelling methods: Report on interlaboratory trials and production of recommended protocols. Mutagenesis 14: 301-315.
22. Pope III CA, Burett RT, Thun MJ, Cale EE, Krewski D, Ito K, Thurston GD. 2002. Lung cancer cardiopulmonary mortality and long-term exposure to fine particulate air pollution. JAMA 287: 1132-1141.
23. Randerath K, Randerath E, Agrawal HP, Gupta RC, Schurdak ME, Reddy MV. 1985. Postlabeling methods for carcinogen-DNA adduct analysis. Environ Health Perspect 62: 57-65.
24. Randerath K, Randerath E, Zhou GD, Li D. 1999. Bulky endogenous DNA modifications (I-compounds) -possible structural origins and functional implications. Mutat Res 424: 183-194.
25. Reddy MV, Randerath K. 1986. Nuclease P1-mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 7: 1543-1551.
26. Rinsky RA, Smith AB, Hornung R, Filloon TG, Young RJ, Okun AH, Landrigan PJ. 1987. Benzene and leukemia. An epidemiologic risk assessment. N Engl J Med 23; 316: 1044-1050.
27. Robinson JC, Paxman DG. 1992. The role of threshold limit values in U.S. air pollution policy. Am J Ind Med 21: 383-396.
28. Ruchirawat M, Mahidol C, Tangjarukij C, Pui-ock S, Jensen O, Kampeerawipakorn O, Tuntaviroon J, Aramphongphan A, Autrup H. 2002. Exposure to genotoxins present in ambient air in Bangkok, Thailand-Particle associated polycyclic aromatic hydrocarbons and biomarkers. Sci Total Environ 287: 121-132.
29. Ruchirawat M, Navasumrit P, Settachan D, Tuntawiroon J, Buthbumrung N, Sharma S. 2005. Measurement of genotoxic air pollutants exposures in street vendors and school children in and near Bangkok. Toxicol Appl Pharmacol 206: 207-214.
30. Ruchirawat M, Settachan D, Navasumrit P, Tuntawiroon J, Autrup H. 2007. Assessment of potential cancer risk in children exposed to urban air pollution in Bangkok, Thailand. Toxicol Lett 168: 200-209.
31. 32P-postlabelling. Mutat Res 416: 67-84.
32. Weaver VM, Davoli CT, Heller P, Fitzwilliam A, Peters H, Sunyer J, Murphy SE, Goldstein GW, Groopman JD. 1996. Benzene exposure, assessed by urinary trans, trans-muconic acid, in urban children with elevated blood lead levels. Environ Health Perspect 104: 318-323.
33. WHO. 1983. Polycyclic aromatic compounds. 1. Chemicals, environmental and experimental data. In evaluation of carcinogenic risk of chemical to humans. IARC Monogr Eval Carcinog Risk Chem Man 32: 1-477.