Spirocyclization of an N-acyliminium ion with substituted pyridine: Stereoselective synthesis of tetracyclic spirolactams possessing the pyridone nucleus

Heterocycles

Volumn 82, Issue 1, 2010, Pages 257-261

  Abe, Hideki ^a   Takaya, Kei Ichi ^b   Watanabe, Kazuhiro ^a   Aoyagi, Sakae ^b   Kibayashi, Chihiro ^b   Katoh, Tadashi ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79751504183     PISSN: 03855414     EISSN: 18810942     Source Type: Journal    
DOI: 10.3987/COM-10-S(E)13     Document Type: Article

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21. 4), and concentrated in vacuo. The residue was purified by column chromatography (CHCl3-MeOH, 30:1) to give 12 (16.1 mg, 44%) and 13 (9.4 mg, 27%), respectively.
22. + + H) 377.2229, found 377.2229.
23. 3): Δ 25.1, 25.2, 25.3, 30.5, 30.9, 32.8, 34.0, 34.3, 44.2, 44.7, 68.8, 118.4, 118.9, 127.5, 128.4 (2C), 129.1 (2C), 138.2, 140.1, 164.8, 176.0.
24. 3; Z = 4.
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