Protein C levels in patients with Legg-Calve-Perthes disease: Is it a true deficiency?

Journal of Pediatric Orthopaedics

Volumn 26, Issue 2, 2006, Pages 200-203

  Mehta, J S ^a,c   Conybeare, M E ^a   Hinves, B L ^b   Winter, J B M ^a  

^a KENT AND CANTERBURY HOSPITAL   (United Kingdom)

^b East Sussex Healthcare NHS Trust   (United Kingdom)

^c NONE   (United Kingdom)

Author keywords

Legg Calve Perthes disease (LCPD); Passive smoking; Protein C deficiency

Indexed keywords

PROTEIN C;

ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PASSIVE SMOKING; PERTHES DISEASE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN C DEFICIENCY; SCHOOL CHILD; CHILD; INDOOR AIR POLLUTION; INFANT;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; HUMANS; INFANT; LEGG-PERTHES DISEASE; PROTEIN C; PROTEIN C DEFICIENCY; TOBACCO SMOKE POLLUTION;

EID: 33645899632     PISSN: 02716798     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.bpo.0000194698.21645.37     Document Type: Article

References (34)

1. Egan RM, Munn RK. Catastrophic antiphospholipid antibody syndrome presenting with multiple thromboses and sites of avascular necrosis. J Rhematol. 1994;21:2376-2379.
2. Korompilias AV, Gilkeson GS, Ortel TL, et al. Anticardiolipin antibodies and osteonecrosis of the femoral head. Clin Orthop. 1997;345:174-180.
3. Arruda V, Belangero WD, Ozelo M, et al. Inherited risk factors for thrombophilia among children with Legg-Calve-Perthes disease. J Pediatr Orthop. 1999;19:84-87.
4. Schaefer AI. Hypercoagulable states: molecular genetics applied to clinical practice. Lancet. 1994;344:1739-1742.
5. Dahlback B, Stenflo J. A natural anticoagulant pathway: proteins C, S, C4b-binding protein and thrombomodulin. In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 3rd ed. Philadelphia: Lippincott, 1994:671-688.
6. Andrew M, Vegh P, Johnston M, et al. Maturation of the haemostatic system during childhood. Blood. 1992;80:1998-2005.
7. Grogan DP, Love SM, Ogden JA, et al. Chondro-osseous growth abnormalities after meningococcemia. A clinical and histopathological study. J Bone Joint Surg [Am]. 1989;71:920-928.
8. Liu SL, Ho TC. The role of venous hypertension in the pathogenesis of Legg-Perthes disease. A clinical and experimental study. J Bone Joint Surg [Am]. 1991;73:194-200.
9. Catterall A, Pringle J, Byers PD, et al. A review of the morphology of Perthes' disease. J Bone Joint Surg [Br]. 1982;64:269-275.
10. Neidel J, Boddenberg B, Zander D, et al. Thyroid function in Legg-Calve-Perthes disease: cross-sectional and longitudinal study. J Pediatr Orthop. 1993;13:592-597.
11. Kleinman RG, Bleck EE. Increased blood viscosity in patients with Legg-Perthes disease: a preliminary report. J Pediatr Orthop. 1981;1:131-136.
12. Glueck CJ, Freiberg RA, Crawford A, et al. Secondhand smoke, hypofibrinolysis, and Legg-Perthes disease. Clin Orthop. 1998;352:159-167.
13. Mata SG, Aicua EA, Ovejero AH, et al. Legg-Calve-Perthes disease and passive smoking. J Pediatr Orthop. 2000;20:326-330.
14. Gallistl S, Reitinger T, Linhart W, et al. The role of inherited thrombotic disorders in the aetiology of Legg-Calve-Perthes disease. J Pediatr Orthop. 1999;19:82-83.
15. Glueck CJ, Glueck HI, Greenfield D, et al. Protein C and S deficiency, thrombophilia, and hypofibrinolysis: pathophysiologic causes of Legg-Perthes disease. Pediatr Res. 1994;35:383-388.
16. Glueck CJ, Crawford A, Roy D, et al. Association of antithrombotic factor deficiencies and hypofibrinolysis with Legg-Perthes disease. J Bone Joint Surg [Am]. 1996;78:3-13.
17. Glueck CJ, McMahon RE, Bouquot J, et al. Thrombophilia, hypofibrinolysis, and alveolar osteonecrosis of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;81:557-566.
18. Koster T, Rosendaal FR, de Ronde H. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet. 1993;342:1503-1506.
19. Beaule PE, Jarvis JG, Castle WG, et al. Protein C deficiency in a patient with Legg-Calve-Perthes disease and recurrent deep vein thrombosis. Orthopedics. 2002;25:541-543.
20. Sirvent N, Fisher F, el Hayek T, et al. Absence of congenital prethrombotic disorders in children with Legg-Perthes disease. J Pediatr Orthop B. 2000;9:24-27.
21. Hresko MT, McDougall PA, Gorlin JB, et al. Prospective reevaluation of the association between thrombotic diathesis and Legg-Perthes disease. J Bone Joint Surg [Am]. 2002;84:1613-1618.
22. Gallistl S, Reitinger T, Linhart W, et al. The role of inherited thrombotic disorders in the etiology of Legg-Calve-Perthes disease. J Pediatr Orthop. 1999;19:82-83.
23. Glueck CJ, Brandt G, Gruppo R, et al. Resistance to activated protein C and Legg-Perthes disease. Clin Orthop. 1997;338:139-152.
24. Eldridge J, Dilley A, Austin H, et al. The role of protein C, protein S, and resistance to activated protein C in Legg-Perthes disease. Pediatrics. 2001;107:1329-1334.
25. Koo KH, Song HR, Ha -C, et al. Role of thrombotic and fibrinolytic disorders in the etiology of Perthes disease. Clin Orthop. 2002;399:162-167.
26. Thomas DP, Morgan G, Tayton K. Perthes disease and the relevance of thrombophilia. J Bone Joint Surg [Br]. 1999;81:691-695.
27. Hayek S, Kenet G, Lubetsky A, et al. Does thrombophilia play an aetiological role in Legg-Calve-Perthes disease? J Bone Joint Surg [Br]. 1999;81:686-690.
28. Liesner RJ. Does thrombophilia cause Perthes' disease in children? J Bone Joint Surg [Br]. 1999;81:565.
29. Gruppo R, Glueck CJ, Wall E, et al. Legg-Perthes disease in three siblings, two heterozygous and one homozygous for the factor V Leiden mutation. J Pediatr. 1998;132:885-888.
30. Chung SM. The arterial supply of the developing proximal end of the human femur. J Bone Joint Surg [Am]. 1976;58:961-970.
31. Trueta JHarrison MHM. The normal vascular anatomy of the femoral head in adult man. J Bone Joint Surg [Br]. 1953;35:442-461.
32. Trueta J. The normal vascular anatomy of the femoral head in adult man. Clin Orthop. 1997;334:6-14.
33. Ferguson AB Jr. Segmental vascular changes in the femoral head in children and adults. Clin Orthop. 1985;200:291-298.
34. Gregosiewicz A, Okonski M, Stolecka D, et al. Ischaemia of the femoral head in Perthes' disease: is the cause intra-or extravascular? J Pediatr Orthop. 1989;9:160-162.