Pseudomonas aeruginosa acquisition on an intensive care unit: Relationship between antibiotic selective pressure and patients' environment

Critical Care

Volumn 15, Issue 1, 2011, Pages

  Boyer, Alexandre ^a,e   Doussau, Adélaïde ^b,c,d   Thiébault, Rodolphe ^b,c,d   Venier, Anne Gaëlle ^a,e   Tran, Van ^a   Boulestreau, Hélène ^a   Bébéar, Cécile ^a   Vargas, Frédéric ^a   Hilbert, Gilles ^a   Gruson, Didier ^a   Rogues, Anne Marie ^a,e  

^a HÔPITAL PELLEGRIN   (France)

^b BORDEAUX UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ DE BORDEAUX   (France)

^d INSERM   (France)

^e INSERM U657   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; CARBAPENEM DERIVATIVE; CARBOXYPENICILLIN; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; CORTICOSTEROID; COTRIMOXAZOLE; FOSFOMYCIN; IMMUNOSUPPRESSIVE AGENT; ISOPENICILLIN N; MACROLIDE; METRONIDAZOLE; NEOMYCIN; PENICILLIN DERIVATIVE; PENICILLIN G; PIPERACILLIN PLUS TAZOBACTAM; POLYPEPTIDE ANTIBIOTIC AGENT; PRISTINAMYCIN; QUINOLONE DERIVATIVE; RIFAMPICIN; TAP WATER; TIMENTIN; UNCLASSIFIED DRUG; UREIDOPENICILLIN; ANTIINFECTIVE AGENT;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL PERITONITIS; BACTERIAL PNEUMONIA; BACTERIUM ISOLATE; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED STUDY; CORTICOSTEROID THERAPY; ENDEMIC DISEASE; FECES ANALYSIS; FEMALE; HOSPITAL ADMISSION; HOSPITAL BED; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MICROBIOLOGICAL EXAMINATION; NOSE SMEAR; OPEN STUDY; POLLUTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; RECTUM; RISK FACTOR; SPUTUM CULTURE; THROAT CULTURE; URINALYSIS; CROSS INFECTION; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED;

ADULT; AGED; ANTI-BACTERIAL AGENTS; CROSS INFECTION; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; WATER MICROBIOLOGY;

EID: 79651471648     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc10026     Document Type: Article

References (29)

1. Souli M, Galani I, Giamarellou H. Emergence of extensively drug-resistant and pandrug-resistant gram negative bacilli in Europe. Euro Surveill 2008, 13:pii: 19045.
2. Bonten MJ, Bergmans DC, Ambergen AW, De Leeuw PW, Van der Geest S, Stobberingh EE, Gaillard CA. Risk factors for pneumonia, and colonization of respiratory tract and stomach in mechanically ventilated ICU patients. Am J Respir Crit Care Med 1996, 154:1339-1346.
3. Rogues AM, Boulestreau H, Lasheras A, Boyer A, Gruson D, Merle C, Castaing Y, Bébéar CM, Gachie JP. Contribution of tap water to patient colonisation with Pseudomonas aeruginosa in a medical intensive care unit. J Hosp Infect 2007, 67:72-78. 10.1016/j.jhin.2007.06.019, 17728016.
4. Bertrand X, Thouverez M, Talon D, Boillot A, Capellier G, Floriot C, Hélias JP. Endemicity, molecular diversity and colonization routes of Pseudomonas aeruginosa in intensive care units. Intensive Care Med 2001, 27:1263-1268. 10.1007/s001340100979, 11511937.
5. Talon D, Mulin B, Rouget C, Bailly P, Thouverez M, Viel JF. Risk and routes for ventilator-associated pneumonia with Pseudomonas aeruginosa. Am J Respir Crit Care Med 1998, 157:978-984.
6. Agodi A, Barchitta M, Cipresso R, Giaquinta L, Romeo MA, Denaro C. Pseudomonas aeruginosa carriage, colonization, and infection in ICU patients. Intensive Care Med 2007, 33:1155-1161. 10.1007/s00134-007-0671-6, 17503016.
7. Blanc DS, Nahimana I, Petignat C, Wenger A, Bille J, Francioli P. Faucets as a reservoir of endemic Pseudomonas aeruginosa colonization/infections in intensive care units. Intensive Care Med 2004, 30:1964-1968. 10.1007/s00134-004-2389-z, 15257431.
8. Valles J, Mariscal D, Cortes P, Coll P, Villagrá A, Díaz E, Artigas A, Rello J. Patterns of colonization by Pseudomonas aeruginosa in intubated patients: a 3-year prospective study of 1,607 isolates using pulsed-field gel electrophoresis with implications for prevention of ventilator-associated pneumonia. Intensive Care Med 2004, 30:1768-1775. 10.1007/s00134-004-2382-6, 15243686.
9. Bergmans DC, Bonten MJ, Stobberingh EE, Van Tiel FH, Van der Geest S, De Leeuw PW, Gaillard CA. Colonization with Pseudomonas aeruginosa in patients developing ventilator-associated pneumonia. Infect Control Hosp Epidemiol 1998, 19:853-855. 10.1086/647745, 9831943.
10. Blanc DS, Petignat C, Janin B, Bille J, Francioli P. Frequency and molecular diversity of Pseudomonas aeruginosa upon admission and during hospitalization: a prospective epidemiologic study. Clin Microbiol Infect 1998, 4:242-247. 10.1111/j.1469-0691.1998.tb00356.x, 11864338.
11. Bonten MJM, Bergmans DC, Speijer H, Stobberingh EE. Characteristics of polyclonal endemicity of colonization in intensive care units. Implications for infection control. Am J Respir Crit Care Med 1999, 160:1212-1219.
12. Cholley P, Thouverez M, Floret N, Bertrand X, Talon D. The role of water fittings in intensive care rooms as reservoirs for the colonization of patients with Pseudomonas aeruginosa. Intensive Care Med 2008, 34:1428-1433. 10.1007/s00134-008-1110-z, 2491418, 18425499.
13. Berthelot P, Grattard F, Mahul P, Pain P, Jospé R, Venet C, Carricajo A, Aubert G, Ros A, Dumont A, Lucht F, Zéni F, Auboyer C, Bertrand JC, Pozzetto B. Prospective study of nosocomial colonization and infection due to Pseudomonas aeruginosa in mechanically ventilated patients. Intensive Care Med 2001, 27:503-512. 10.1007/s001340100870, 11355118.
14. Hota S, Hirji Z, Stockton K, Lemieux C, Dedier H, Wolfaardt G, Gardam MA. Outbreak of multidrug-resistant Pseudomonas aeruginosa colonization and infection secondary to imperfect intensive care unit room design. Infect Control Hosp Epidemiol 2009, 30:25-33. 10.1086/592700, 19046054.
15. Aumeran C, Paillard C, Robin F, Kanold J, Baud O, Bonnet R, Souweine B, Traore O. Pseudomonas aeruginosa and Pseudomonas putida outbreak associated with contaminated water outlets in an oncohaematology paediatric unit. J Hosp Infect 2007, 65:47-53. 10.1016/j.jhin.2006.08.009, 17141370.
16. Kerr KG, Snelling AM. Pseudomonas aeruginosa: a formidable and ever-present adversary. J Hosp Infect 2009, 73:338-344. 10.1016/j.jhin.2009.04.020, 19699552.
17. Bertrand X, Bailly P, Blasco G, Balvay P, Boillot A, Talon D. Large outbreak in an intensive care unit of colonization or infection with Pseudomonas aeruginosa that overexpressed an active efflux pump. Clin Infect Dis 2000, 31:E9-E14. 10.1086/318117, 11049805.
18. Thuong M, Arvaniti K, Ruimy R, de la Salmonière P, Scanvic-Hameg A, Lucet JC, Régnier B. Epidemiology of Pseudomonas aeruginosa and risk factors for carriage acquisition in an intensive care unit. J Hosp Infect 2003, 53:274-282. 10.1053/jhin.2002.1370, 12660124.
19. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993, 270:2957-2963. 10.1001/jama.270.24.2957, 8254858.
20. Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika 1986, 73:13-22.
21. Akaike H. A new look at the statistical model identification. IEEE Transactions on Automatic Control 1974, 19:716-723.
22. Johnson JK, Smith G, Lee MS, Venezia RA, Stine OC, Nataro JP, Hsiao W, Harris AD. The role of patient-to-patient transmission in the acquisition of imipenem-resistant Pseudomonas aeruginosa colonization in the intensive care unit. J Infect Dis 2009, 200:900-905.
23. Gershman MD, Kennedy DJ, Noble-Wang J, Kim C, Gullion J, Kacica M, Jensen B, Pascoe N, Saiman L, McHale J, Wilkins M, Schoonmaker-Bopp D, Clayton J, Arduino M, Srinivasan A. Multistate outbreak of Pseudomonas fluorescens bloodstream infection after exposure to contaminated heparinized saline flush prepared by a compounding pharmacy. Clin Infect Dis 2008, 47:1372-1379. 10.1086/592968, 18937575.
24. Fourrier F, Cau-Pottier E, Boutigny H, Roussel-Delvallez M, Jourdain M, Chopin C. Effects of dental plaque antiseptic decontamination on bacterial colonization and nosocomial infections in critically ill patients. Intensive Care Med 2000, 26:1239-1247. 10.1007/s001340000585, 11089748.
25. Ewig S, Torres A, El-Ebiary M, Fábregas N, Hernández C, González J, Nicolás JM, Soto L. Bacterial colonization patterns in mechanically ventilated patients with traumatic and medical head injury. Incidence, risk factors, and association with ventilator-associated pneumonia. Am J Respir Crit Care Med 1999, 159:188-198.
26. Bonten MJ, Gaillard CA, van Tiel FH, Smeets HG, van der Geest S, Stobberingh EE. The stomach is not a source for colonization of the upper respiratory tract and pneumonia in ICU patients. Chest 1994, 105:878-884. 10.1378/chest.105.3.878, 8131556.
27. Jonas D, Meyer E, Schwab F, Grundmann H. Genodiversity of resistant Pseudomonas aeruginosa isolates in relation to antimicrobial usage density and resistance rates in intensive care units. Infect Control Hosp Epidemiol 2008, 29:350-357. 10.1086/528811, 18269329.
28. Kolla A, Schwab F, Bärwolff S, Eckmanns T, Weist K, Dinger E, Klare I, Witte W, Ruden H, Gastmeier P. Is there an association between nosocomial infection rates and bacterial cross transmissions?. Crit Care Med 2010, 38:46-50. 10.1097/CCM.0b013e3181b42a9b, 19770743.
29. Kaier K, Frank U, Hagist C, Conrad A, Meyer E. The impact of antimicrobial drug consumption and alcohol-based hand rub use on the emergence and spread of extended-spectrum βlactamase-producing strains: a time-series analysis. J Antimicrob Chemother 2009, 63:609-614. 10.1093/jac/dkn534, 19151036.