Forward-collected simultaneous fluorescence lifetime imaging and coherent anti-Stokes Raman scattering microscopy

Journal of Biomedical Optics

Volumn 16, Issue 2, 2011, Pages

  Slepkov, Aaron D ^a   Ridsdale, Andrew ^a   Wan, Huei Ning ^b   Wang, Ming Hao ^b   Pegoraro, Adrian F ^a,c   Moffatt, Douglas J ^a   Pezacki, John P ^a   Kao, Fu Jen ^b   Stolow, Albert ^a,c  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c QUEEN S UNIVERSITY   (Canada)

Author keywords

fiber optic applications; laser induced fluorescence; nonlinear optics; Raman spectroscopy; scanning microscopy

Indexed keywords

COHERENT ANTI-STOKES RAMAN SCATTERING; COHERENT ANTI-STOKES RAMAN SCATTERING MICROSCOPY; FEMTOSECONDS; FIBER OPTIC APPLICATIONS; FIELD OF VIEWS; FLUORESCENCE LIFETIME IMAGING; FLUORESCENCE LIFETIMES; LASER-INDUCED FLUORESCENCE; LIVE CELL; LOSS OF LIGHTS; MULTI-MODAL; SCANNING MICROSCOPY; TIME GATING; TIME-CORRELATED SINGLE-PHOTON COUNTING; TIMING FIDELITY; TWO PHOTON;

COHERENT SCATTERING; FIBERS; FLUORESCENCE; FORWARD SCATTERING; LASER EXCITATION; LASER PRODUCED PLASMAS; MULTIMODE FIBERS; NONLINEAR OPTICS; OPTICAL MATERIALS; PHOTONS; RAMAN SCATTERING;

RAMAN SPECTROSCOPY;

ARTICLE; EQUIPMENT; EQUIPMENT DESIGN; FLUORESCENCE MICROSCOPY; IMAGE ENHANCEMENT; INSTRUMENTATION; OPTICAL COHERENCE TOMOGRAPHY; RAMAN SPECTROMETRY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; IMAGE ENHANCEMENT; MICROSCOPY, FLUORESCENCE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTRUM ANALYSIS, RAMAN; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 79551714481     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3490641     Document Type: Article

References (20)

1. W. Becker, A. Bergmann, M. A. Hink, K. Konig, K. Benndorf, and C. Biskup, Fluorescence lifetime imaging by time-correlated single-photon counting., (Pubitemid 37541971)
2. K. Suhling, P. M. W. French, and D. Phillips, Time-resolved fluorescence microscopy., Photochem. Photobiol. Sci. 4, 13-22 (2005). 10.1039/b412924p (Pubitemid 40207982)
3. P. R. Selvin, The renaissance of fluorescence resonance energy transfer., Nat. Struct. Biol. 7, 730-734 (2000). 10.1038/78948
4. P. O. Provenzano, K. W. Eliceiri, J. M. Campbell, D. R. Inman, J. G. White, and P. J. Keely, Collagen reorganization at the tumor-stromal interface facilitates local invasion., BMC Med. 4, 38 (2006). 10.1186/1741-7015-4-38 (Pubitemid 46210997)
5. E. O. Potma and X. S. Xie, Detection of single lipid bilayers with coherent anti-Stokes Raman scattering (CARS) microscopy., J. Raman. Spectrosc. 34, 642-650 (2003). 10.1002/jrs.1045
6. J.-X. Cheng, A. Volkmer, and X. S. Xie, Theoretical and experimental characterization of coherent anti-Stokes Raman scattering microscopy., J. Opt. Soc. Am. B 19, 1363-1375 (2002). 10.1364/JOSAB.19.001363
7. J.-X. Cheng, A. Volkmer, L. D. Book, and X. S. Xie, An epi-detected coherent anti-Stokes Raman scattering (E-CARS) microscope with high spectral resolution and high sensitivity., J. Phys. Chem. B 105, 1277-1280 (2001). 10.1021/jp003774a (Pubitemid 32252357)
8. I. W. Schie, T. Weeks, G. P. McNerney, S. Fore, J. K. Sampson, S. Wachsmann-Hogiu, J. C. Rutledge, and T. Huser, Simultaneous forward and epi-CARS microscopy with a single detector by time-correlated single photon counting., Opt. Express 16, 2168-2175 (2008). 10.1364/OE.16.002168 (Pubitemid 351240059)
9. S. Ly, G. McNerney, S. Fore, J. Chan, and T. Huser, Time-gated single photon counting enables separation of CARS microscopy data from multiphoton-excited tissue autofluorescence., Opt. Express 15, 16839-16851 (2007). 10.1364/OE.15.016839 (Pubitemid 350260543)
10. S. O. Konorov, C. H. Glover, J. M. Piret, J. Bryan, H. G. Schulze, M. W. Blades, and R. F. B. Turner, In situ analysis of living embryonic stem cells by coherent anti-Stokes Raman microscopy., Anal. Chem. 79, 7221-7225 (2007). 10.1021/ac070544k (Pubitemid 47438708)
11. W. Becker, Advanced Time-correlated Single-photon Counting Techniques, pp. 282-284, Springer, Heidelberg (2005).
12. A. Liebert, H. Wabnitz, D. Grosenick, and R. Macdonald, Fiber dispersion in time domain measurements compromising the accuracy of determination of optical properties of strongly scattering media., J. Biomed. Opt. 8, 512-516 (2003). 10.1117/1.1578088
13. M. Kress, T. Meier, R. Steiner, F. Dolp, R. Erdmann, U. Ortmann, and A. Rck, Time-resolved microspectrofluorometry and fluorescence lifetime imaging of photosensitizers using picosecond pulsed diode lasers in laser scanning microscopes., J. Biomed. Opt. 8, 26-32 (2003). 10.1117/1.1528595
14. W. Becker, A. Bergmann, and C. Biskup, Multi-spectral fluorescence lifetime imaging by TCSPC., Microsc. Res. Tech. 70, 403-409 (2007). 10.1002/jemt.20432 (Pubitemid 46786937)
15. A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, Optimally chirped multimodal CARS microscopy based on a single ti:sapphireoscillator., Opt. Express 17, 2984-2996 (2009). 10.1364/OE.17.002984
16. A. D. Slepkov, A. Ridsdale, A. F. Pegoraro, G. Labroille, and A. Stolow, Optimizing spectral resolution in supercontinuum-generation-based multimodal fs CARS microscopy., CLEO 2010 Technical Digest, CWD2, 1-2 (2010).
17. R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism., Virology 394, 130-142 (2009). 10.1016/j.virol.2009.08.022
18. B. E. A. Saleh and M. C. Teich, Fundamentals of Photonics, Chap. 8, Wiley, New York (1991). 10.1002/0471213748
19. ISS, Inc., Lifetime data of selected fluorophores., http://www.iss.com/ resources/fluorophores.html, accessed May 15, 2010.
20. S. Murata, P. Herman, H.-J. Lin, and J. Lakowicz, Fluorescence lifetime imaging of nuclear DNA; effect of fluorescence resonance energy transfer., Cytometry 41, 178-185 (2000). 10.1002/1097-0320