Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer

Molecular Medicine Reports

Volumn 4, Issue 2, 2011, Pages 363-368

  Kalathas, Dimitrios ^a   Theocharis, Dimitrios A ^b   Bounias, Dimitrios ^b   Kyriakopoulou, Dora ^b   Papageorgakopoulou, Nikoletta ^a   Stavropoulos, Michael S ^b   Vynios, Demitrios H ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

Biosynthesis; Colon; Disease; Enzymes; Glycosaminoglycans; Rectum

Indexed keywords

CHONDROITIN SULFATE GLUCURONYLTRANSFERASE PROTEIN; CHONDROITIN SYNTHASE 1 PROTEIN; CHONDROITIN SYNTHASE 2 PROTEIN; CHONDROITIN SYNTHASE 3 PROTEIN; GLUCURONOSYLTRANSFERASE; GLYCOSAMINOGLYCAN; UNCLASSIFIED DRUG;

ADENOMA; ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER STAGING; CECUM; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; PROTEIN EXPRESSION; RECTUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGMOID; TRANSVERSE COLON; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CHONDROITIN SULFATES; COLORECTAL NEOPLASMS; DERMATAN SULFATE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCURONOSYLTRANSFERASE; HUMANS; MALE; MIDDLE AGED; N-ACETYLGALACTOSAMINYLTRANSFERASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79551694792     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.431     Document Type: Article

References (22)

1. Ricciardelli C, Mayne K Sykes PJ, Raymond WA, McCaul K, Marshall VR, Tilley WD, Skinner JM and Horsfall DJ: Elevated stromal chondroitin sulfate glycosaminoglycan predicts progression in early-stage prostate cancer. Clin Cancer Res 13: 983-992, 1997. (Pubitemid 27252948)
2. Kitagawa H, Uyama T and Sugahara K: Molecular cloning and expression of a human chondroitin synthase: J Biol Chem 276: 38721-38726, 2001.
3. Evers MR, Xia G, Kang HG, Schachner M and Baenziger JU Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase. J Biol Chem 276: 36344-36353, 2001.
4. Kitagawa H, Izumikawa T, Uyama T and Sugahara K: Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization. J Biol Chem 278: 23666-23671, 2003. (Pubitemid 36833253)
5. Okuda T, Mita S, Yamauchi S, Matsubara T, Yagi F, Yamamori D, Fukuta M, Kuroiwa A, Matsuda Y and Habuchi O: Molecular cloning, expression, and chromosomal mapping of human, chondroitin 4-Sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-Sulfotransferase. J Biochem 128: 763-770, 2000.
6. Yada T, Gotoh M, Sato T, Shionyu M, Kwon YD, Togayashi A, Kudo T, Watanabe H, Narimatsu H and Kimata K: Chondroitin Sulfate Synthase-2: molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities. J Biol Chem 278: 30235-30247, 2003. (Pubitemid 36962418)
7. Yada T, Sato T, Kaseyama H, Gotoh M, Iwasaki H, Kikuchi N, Kwon YD, Togayashi A, Kudo T, Watanabe H, Narimatsu H and Kimata K: Chondroitin sulfate synthase-3 molecular cloning and characterization. J Biol Chem 278: 39711-39725, 2003. (Pubitemid 37248533)
8. Gotoh M, Sato T, Akashima T, et al: Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis. J Biol Chem 277: 38189-38196, 2002. (Pubitemid 35154672)
9. Gotoh M, Yada T, Sato T, Akashima T, Iwasaki H, Mochizuki H, Inaba N, Togayachi A, Kudo T, Watanabe H, Kimata K and Narimatsu H: Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine. J Biol Chem 277: 38179-38188, 2002. (Pubitemid 35154671)
10. Jayson GC, Lyon M, Paraskeva C, Turnbull JE, Deakin JA and Gallagher JT: Heparan sulfate undergoes specific structural changes during the progression from human colon adenoma to carcinoma in vitro. J Biol Chem 273: 51-57, 1998. (Pubitemid 28042175)
11. Kalathas D, Theocharis DA, Bounias D, Kyriakopoulou D, Papageorgakopoulou N, Stavropoulos MS and Vynios D: Alterations of glycosaminoglycan disaccharide content and composition in colorectal cancer: structural and expressional studies. Oncol Rep 22: 369-375, 2009
12. Papadas TA, Stylianou M, Mastronikolis NS, Papageorgakopoulou N, Skandalis S, Goumas P, Theocharis DA and Vynios DH: Alterations in the content and composition of glycosaminoglycans in human laryngeal carcinoma. Acta Otolaryngol 3: 330-337, 2002. (Pubitemid 34546035)
13. Skandalis SS, Stylianou M, Vynios DH, Papageorgakopoulou N and Theocharis DA: The structural and compositional changes of glycosaminoglycans are closely associated with tissue type in human laryngeal cancer. Biochimie 89: 1573-1580, 2007. (Pubitemid 350122850)
14. Theocharis AD, Tsara M, Papageorgacopoulou N, Karavias DD and Theocharis DA: Pancreatic carcinoma is characterized by elevated content of hyaluronan and chondroitin sulphate with altered disaccharide composition. Biochim Biophys Acta 1502: 201-206, 2000.
15. Theocharis AD and Theocharis DA: High-performance capillary electrophoretic analysis of hyaluronan and galactosaminoglycan-disaccharides in gastrointestinal carcinomas. Differential disaccharide composition as a possible tool-indicator for malignancies. Biomed Chromatogr 16: 157-161, 2002.
16. Theocharis AD, Vynios DH, Papageorgakopoulou N, Skandalis SS and Theocharis DA: Altered content composition and structure of glycosaminoglycans and proteoglycans in gastric carcinoma. Int J Biochem Cell Biol 35: 376-390, 2003. (Pubitemid 36084460)
17. Tsara ME, Papageorgacopoulou N, Karavias DD and Theocharis DA: Distribution and changes of glycosaminoglycans in neoplasias of rectum. Anticancer Res 15: 2107-2012, 1995.
18. Tsara ME, Theocharis AD and Theocharis DA: Compositional and structural alterations of proteoglycans in human rectum carcinoma with special reference to versican and decorin. Anticancer Res 22: 2893-2898, 2002. (Pubitemid 36069330)
19. Wu MM, Llopis J, Adams S, McCaffery JM, Kulomaa MS, Machen TE, Moore HPH and Tsien RY Organelle pH studies using targeted avidin and fluorescein-biotin. J Chem Biol 7: 197-209, 2000. (Pubitemid 30147204)
20. Christopoulos TA, Papageorgakopoulou N, Theocharis DA, Aletras AJ, Tsiganos CP, Papadas TA, Mastronikolis NS, Goumas P and Vynios DH: Diagnostic and classification value of metalloproteinases in squamous human laryngeal carcinoma. Int J Oncol 25: 481-485, 2004.
21. Izumikawa T, Koike T, Shiozawa S, Sugahara K, Tamura J and Kitagawa H: Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members. J Biol Chem 283: 11396-11406, 2008.
22. Tiedemann K, Olander B, Eklund E, Todorova L, Bengtsson M, Maccarana M, Westergren-Thorsson G and Malmström A: Regulation of the chondroitin/dermatan fine structure by transforming growth factor-1 through effects on polymer-modifying enzymes. Glycobiology 15: 1277-1285, 2005. (Pubitemid 41724332)