The effect of adding intrathecal magnesium sulphate to morphine-fentanyl spinal analgesia after thoracic surgery. A prospective, double-blind, placebo-controlled research study;Effet de l'adjonction intrathécale de sulphate de magnésium en complément d'une association morphine-fentanyl par voie rachidienne pour l'analgésie après chirurgie thoracique: une étude

Annales Francaises d'Anesthesie et de Reanimation

Volumn 30, Issue 1, 2011, Pages 25-30

  Ouerghi, S ^a   Fnaeich, F ^a   Frikha, N ^b   Mestiri, T ^a   Merghli, A ^a   Mebazaa, M S ^b   Kilani, T ^a   Ben Ammar, M S ^b  

^a ABDERRAHMAN MAMI HOSPITAL   (Tunisia)

^b MONGI SLIM HOSPITAL   (Tunisia)

Author keywords

Adjuvant; Intrathecal analgesia; Magnesium; Morphine; Thoracic surgery

Indexed keywords

ATRACURIUM; FENTANYL; FENTANYL CITRATE; HALOTHANE; MAGNESIUM SULFATE; MORPHINE; PARACETAMOL; PLACEBO; THIOPENTAL;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; BLADDER CATHETERIZATION; BREATHING RATE; COUGHING; DIPLOPIA; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEART ARRHYTHMIA; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MUSCLE WEAKNESS; NAUSEA AND VOMITING; OXYGEN SATURATION; PAIN ASSESSMENT; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PROSPECTIVE STUDY; PRURITUS; RANDOMIZED CONTROLLED TRIAL; REST; SEDATION; SIDE EFFECT; SLURRED SPEECH; SOMNOLENCE; SPINAL ANESTHESIA; SYSTOLIC BLOOD PRESSURE; THORAX SURGERY; URINE RETENTION; VISUAL ANALOG SCALE;

ADOLESCENT; ADULT; AGED; ANALGESIA, PATIENT-CONTROLLED; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ANESTHESIA, GENERAL; DOUBLE-BLIND METHOD; ENDPOINT DETERMINATION; FEMALE; FENTANYL; HUMANS; INJECTIONS, INTRAVENOUS; INJECTIONS, SPINAL; LUNG; MAGNESIUM SULFATE; MALE; MIDDLE AGED; MORPHINE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; POSTOPERATIVE NAUSEA AND VOMITING; PROSPECTIVE STUDIES; RECOVERY ROOM; THORACIC SURGICAL PROCEDURES; TUNISIA; YOUNG ADULT;

EID: 79551690197     PISSN: 07507658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.annfar.2010.10.018     Document Type: Article

References (32)

1. Kavanagh B.P., Katz J., Sandler A.N. Pain control after thoracic surgery. A review of current techniques. Anesthesiology 1994, 81:737-759.
2. Slinger P. New trends in anaesthesia for thoracic surgery including thoracoscopy. Can J Anaesth 1995, 42:R77-R84.
3. Pain relief after thoracotomy. Lancet 1976;1:576. [Editorial].
4. Liu S., Carpenter R.L., Neal J.M. Epidural anaesthesia and analgesia. Anesthesiology 1995, 82:1474-1506.
5. De Leon-Casaola O.A., Parker B., Lema M.J., Harisson P., Massey J. Postoperative epidural bupivacaïne-morphine therapy. Experience with 4,227 surgical cancer patients. Anaesthesiology 1994, 81:368-375.
6. Liu N., Kuhlman G., Dalibon N., Moutafis M., Fischler M. A randomized, double-blinded comparison of intrathecal morphine, sufentanil and their combination versus IV morphine patient-controlled analgesia for postthoracotomy pain. Anesth Analg 2001, 92:31-36.
7. Buvanendran A., McCarthy R.J., Kroin J.S., Leong W., Perry P., Tuman K.J. Intrathecal magnesium prolongs fentanyl analgesia: a prospective, randomized, controlled trial. Anesth Analg 2002, 95:661-666.
8. Ozalevli M., Cetin T.O., Unlugenc H., Guler T., Isik G. The effect of adding intrathecal magnesium sulphate to bupivacaine-fentanyl spinal anaesthesia. Acta Anaesthesiol Scand 2005, 49:1514-1519.
9. Chanimov M., Cohen M.L., Grinspun Y., Herbert M., Reif R., Kaufman I., et al. Neurotoxicity after spinal anaesthesia induced by serial intrathecal injections of magnesium sulphate. An experimental study in a rat model. Anaesthesia 1997, 52:223-228.
10. Simpson J.I., Eide T.R., Schiff G.A., Clagnaz J.F., Hossain I., Tverskoy A., et al. Intrathecal magnesium sulfate protects the spinal cord from ischemic injury during thoracic aortic cross-clamping. Anesthesiology 1994, 81:1493-1499.
11. Jellish W.S., Zhang X., Langen K.E., Spector M.S., Scalfani M.T., White F.A. Intrathecal magnesium sulfate administration at the time of experimental ischemia improves neurological functioning by reducing acute and delayed loss of motor neurons in the spinal cord. Anesthesiology 2008, 108:78-86.
12. Kroin J.S., McCarthy R.J., Von Roenn N., Schwab B., Tuman K.J., Ivankovich A.D. Magnesium sulfate potentiates morphine antinociception at the spinal level. Anesth Analg 2000, 90:913-917.
13. McCarthy R.J., Kroin J.S., Tuman K.J., Penn R.D., Ivankovich A.D. Antinociceptive potentiation and attenuation of tolerance by intrathecal co-infusion of magnesium sulfate and morphine in rats. Anesth Analg 1998, 86:830-836.
14. Altman D.G., Schulz K.F., Moher D., Egger M., Davidoff F., Elbourne D., et al. The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med 2001, 134:663-694.
15. Parkhouse J., Lambrechts W., Simpson B.R. The incidence of postoperative pain. Br J Anaesth 1961, 33:345-353.
16. Gwirtz K.H., Young J.V., Byers R.S., Alley C., Levin K., Walker S.G., et al. The safety and efficacy of intrathecal opioid analgesia for acute postoperative pain: seven years experience with 5969 surgical patients at Indiana University Hospital. Anesth Analg 1999, 88:599-604.
17. Neustein S.M., Cohen E. Intrathecal morphine during thoracotomy. Part II: effect on postoperative meperidine requirements and pulmonary function tests. J Cardiothorac Vasc Anesth 1993, 7:157-159.
18. Mason N., Gondret R., Junca A., Bonnet F. Intrathecal sufentanil and morphine for post-thoracotomy pain relief. Br J Anaesth. 2001, 86:236-240.
19. Reuben S.S., Dunn S.M., Duprat K.M., O'Sullivan P. An intrathecal fentanyl dose-response study in lower extremity revascularization procedures. Anesthesiology 1994, 81:1371-1375.
20. Varrassi G., Celleno D., Capogna G., Costantino P., Emanuelli M., Sebastiani M., et al. Ventilatory effects of subarachnoid fentanyl in the elderly. Anaesthesia 1992, 47:558-562.
21. Chaney M.A., Furry P.A., Fluder E.M., Slogoff S. Intrathecal morphine for coronary artery bypass grafting and early extubation. Anesth Analg 1997, 84:241-248.
22. D'Angelo R., Evans E., Dean L.A., Gaver R., Eisenach J.C. Spinal clonidine prolongs labor analgesia from spinal sufentanil and bupivacaine. Anesth Analg 1999, 88:573-576.
23. Owen M.D., Ozsaraç O., Sahin S., Uçkunkaya N., Kaplan N., Magunaci I. Low-dose clonidine and neostigmine prolong the duration of intrathecal bupivacaine-fentanyl for labor analgesia. Anesthesiology 2000, 92:361-366.
24. Arcioni R., Palmisani S., Tigano S., Santorsola C., Sauli V., Romano S., et al. Combined intrathecal and epidural magnesium sulphate supplementation of spinal anesthesia to reduce post-operative analgesic requirements: a prospective, randomized, double-blind, controlled trial in patients undergoing major orthopedic surgery. Acta Anaesthesiol Scand 2007, 51:482-489.
25. Woolf C.J., Chong M.S. Preemptive analgesia: treating postoperative pain by preventing the establishment of central sensitization. Anesth Analg 1993, 77:362-379.
26. Ascher P., Nowak L. Electrophysiological studies of NMDA receptors. Trends Neurosci 1987, 10:284-288.
27. McKee J.A., Brewer R.P., Macy G.E., Phillips-Bute B., Campbell K.A., Borel C.O., et al. Analysis of the brain bioavailability of peripherally administered magnesium sulfate: a study in humans with acute brain injury undergoing prolonged induced hypermagnesemia. Crit Care Med 2005, 33:661-666.
28. Unlugenc H., Ozalevli M., Gunduz M., Gunasti S., Urunsak I.F., Guler T., et al. Comparison of intrathecal magnesium, fentanyl, or placebo combined with bupivacaine 0. 5% for parturients undergoing elective cesarean delivery Acta Anaesthesiol Scand. 2009, 53:346-353.
29. Bilir A., Gulec S., Erkan A., Ozcelik A. Epidural magnesium reduces postoperative analgesic requirement. Br J Anaesth. 2007, 98:519-523.
30. Birbicer H., Doruk N., Cinel I., Atici S., Avlan D., Bilgin E., et al. Could adding magnesium as adjuvant to ropivacaine in caudal anaesthesia improve postoperative pain control?. Pediatr Surg Int 2007, 23:195-198.
31. Askar F.Z., Kocabas S., Yucel S., Samancilar O., Cetin H., Uyar M. The efficacy of intrathecal morphine in post-thoracotomy pain management. J Int Med Res 2007, 35:314-322.
32. Ghrab B.E., Maatoug M., Kallel N., Khemakhem K., Chaari M., Kolsi K., et al. L'adjonction de sulfate de magnésium à la morphine en intrathécal améliore-t-elle l'analgésie après césarienne ?. Ann Fr Anesth Reanim 2009, 28:454-459.