Horizontal DNA Transfer from Donor to Host Cells as an Alternative Mechanism of Epithelial Chimerism after Allogeneic Hematopoietic Cell Transplantation

Biology of Blood and Marrow Transplantation

Volumn 17, Issue 3, 2011, Pages 319-329

  Waterhouse, Miguel ^a   Themeli, Maria ^b   Bertz, Hartmut ^a   Zoumbos, Nicholas ^b   Finke, Jürgen ^a   Spyridonidis, Alexandros ^a,b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

Allogeneic hematopoietic cell transplantation; Apoptotic bodies; DNA chimerism; Horizontal DNA transfer

Indexed keywords

CD15 ANTIGEN; CD3 ANTIGEN; CD45 ANTIGEN; CD68 ANTIGEN; CELL NUCLEUS DNA; LANGERIN;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CELL INTERACTION; CELL NUCLEUS; CHROMOSOME; CYTOPLASM; DNA TRANSFER; EPITHELIUM CELL; FEMALE; GENE TARGETING; HEMATOPOIETIC CELL; HOST CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; KERATINOCYTE; LYMPHOCYTE; MAJOR CLINICAL STUDY; METAPHASE; PHAGOCYTOSIS;

APOPTOSIS; BONE MARROW CELLS; CELL LINE; CELLS, CULTURED; CHIMERISM; CHROMOSOMES, HUMAN, Y; COCULTURE TECHNIQUES; ENZYME INHIBITORS; EPITHELIAL CELLS; FEMALE; GENE TRANSFER, HORIZONTAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTES; LYSOSOMES; MALE; MICROSATELLITE REPEATS; MOUTH MUCOSA; PHAGOCYTOSIS; RECOMBINATION, GENETIC; STROMAL CELLS;

EID: 79551689604     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2010.09.001     Document Type: Article

References (37)

1. Copelan E. Hematopoietic stem-cell transplantation. N Engl J Med 2006, 354:1813-1826.
2. Holden C., Vogel G. Stem cells. Plasticity: time for a reappraisal?. Science 2002, 296:2126-2129.
3. Korbling M., Katz R.L., Khanna A., et al. Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med 2002, 346:738-746.
4. Krause D.S., Theise N.D., Collector M.L., et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001, 105:369-377.
5. Metaxas Y., Zeiser R., Schmitt-Graeff A., et al. Human hematopoietic cell transplantation results in generation of donor-derived epithelial cells. Leukemia 2005, 19:1287-1289.
6. Spyridonidis A., Schmitt-Gräff A., Tomann T., et al. Epithelial tissue chimerism after human hematopoietic cell transplantation is a real phenomenon. Am J Pathol 2004, 164:1147-1155.
7. Tran S.D., Pillemer S.R., Dutra A., et al. Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study. Lancet 2003, 361:1084-1088.
8. Spyridonidis A., Tomann T., Zeiser R., Follo M., Metaxas Y., Finke J. Stem cell plasticity: the debate begins to clarify. Stem Cell Rev 2005, 1:37-43.
9. Jiang Y., Jahagirdar B.N., Reinhardt R.L., et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002, 418:41-49.
10. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
11. Halicka H.D., Bedner E., Darzynkiewicz Z. Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis. Exp Cell Res 2000, 260:248-256.
12. Savill J., Fadok V. Corpse clearance defines the meaning of cell death. Nature 2000, 407:784-788.
13. Vlassov V.V., Laktionov P.P., Rykova E.Y. Extracellular nucleic acids. Bioessays 2007, 29:654-667.
14. Kurland C.G., Canback B., Berg O.G. Horizontal gene transfer: a critical view. Proc Natl Acad Sci U S A 2003, 100:9658-9662.
15. Garcia-Olmo D., García-Olmo D.C., Ontañón J., Martinez E., Vallejo M. Tumor DNA circulating in the plasma might play a role in metastasis. The hypothesis of the genometastasis. Histol Histopathol 1999, 14:1159-1164.
16. Kirsch T., Woywodt A., Beese M., et al. Engulfment of apoptotic cells by microvascular endothelial cells induces proinflammatory responses. Blood 2007, 109:2854-2862.
17. Partsalis T., Chan L.Y., Hurworth M., et al. Evidence of circulating donor genetic material in bone allotransplantation. Int J Mol Med 2006, 17:1151-1155.
18. Rutkowska J., Olszewski W.L. DNA transfer in bacteria and animals (humans). Ann Transplant 2006, 11:16-21.
19. Tysnes B.B., Bjerkvig R. Cancer initiation and progression: involvement of stem cells and the microenvironment. Biochim Biophys Acta 2007, 1775:283-297.
20. Spyridonidis A., Zeiser R., Wasch R., Bertz H., Finke J. Capillary electrophoresis for chimerism monitoring by PCR amplification of microsatellite markers after allogeneic hematopoietic cell transplantation. Clin Transplant 2005, 19:350-356.
21. Imanishi D., Miyazaki Y., Yamasaki R., et al. Donor-derived DNA in fingernails among recipients of allogeneic hematopoietic stem-cell transplants. Blood 2007, 110:2231-2234.
22. Kucia M., Halasa M., Wysoczynski M., et al. Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood: preliminary report. Leukemia 2007, 21:297-303.
23. Vassilopoulos G., Wang P.R., Russell D.W. Transplanted bone marrow regenerates liver by cell fusion. Nature 2003, 422:901-904.
24. Wang X., Willenbring H., Akkari Y., et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003, 422:897-901.
25. Harris R.G., Herzog E.L., Bruscia E.M., Grove J.E., Van Arnam J.S., Krause D.S. Lack of a fusion requirement for development of bone marrow-derived epithelia. Science 2004, 305:90-93.
26. Jang Y.Y., Collector M.I., Baylin S.B., Diehl A.M., Sharkis S.J. Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol 2004, 6:532-539.
27. Aliotta J.M., Sanchez-Guijo F.M., Dooner G.J., et al. Alteration of marrow cell gene expression, protein production, and engraftment into lung by lung-derived microvesicles: a novel mechanism for phenotype modulation. Stem Cells 2007, 25:2245-2256.
28. Ratajczak J., Miekus K., Kucia M., Zhang J., Reca R., Dvorak P., Ratajczak M.Z. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 2006, 20:847-856.
29. Holmgren L., Szeles A., Rajnavölgyi E., et al. Horizontal transfer of DNA by the uptake of apoptotic bodies. Blood 1999, 93:3956-3963.
30. Bergsmedh A., Szeles A., Henriksson M., et al. Horizontal transfer of oncogenes by uptake of apoptotic bodies. Proc Natl Acad Sci U S A 2001, 98:6407-6411.
31. Yan B., Wang H., Li F., Li C.-Y. Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation. Br J Cancer 2006, 95:1696-1700.
32. Stewart C.L., Roux K.J., Burke B. Blurring the boundary: the nuclear envelope extends its reach. Science 2007, 318:1408-1412.
33. Nagata S. DNA degradation in development and programmed cell death. Annu Rev Immunol 2005, 23:853-875.
34. Doerfler W., Hohlweg U., Muller K., Remus R., Heller H., Hertz J. Foreign DNA integration-perturbations of the genome-oncogenesis. Ann N Y Acad Sci 2001, 945:276-288.
35. Ehnfors J., Kost-Alimova M., Luna Persson N., et al. Horizontal transfer of tumor DNA to endothelial cells in vivo. Cell Death Differ 2009, 16:749-757.
36. Janin A., Murata H., Leboeuf C., et al. Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation. Blood 2009, 113:1834-1840.
37. Paszkiewicz G.M., Timm E.A., Mahoney M.C., et al. Increased human buccal cell autofluorescence is a candidate biomarker of tobacco smoking. Cancer Epidemiol Biomarkers Prev 2008, 17:239-244.