MCM3AP Is transcribed from a promoter within an intron of the overlapping gene for GANP

Journal of Molecular Biology

Volumn 406, Issue 3, 2011, Pages 355-361

  Wickramasinghe, Vihandha O ^a   McMurtrie, Paul I A ^a   Marr, Jackie ^a   Amagase, Yoko ^a   Main, Sarah ^a   Mills, Anthony D ^a   Laskey, Ronald A ^a   Takei, Yoshinori ^a,b  

^a HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

gene structure; organisation

Indexed keywords

ACYLTRANSFERASE; GENE PRODUCT; GERMINAL CENTER ASSOCIATED NUCLEAR PROTEIN; NUCLEAR PROTEIN; PROTEIN MCM3AP; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FUNCTION; CONTROLLED STUDY; DNA SEQUENCE; GENE LOCUS; GENE STRUCTURE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTRON; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION;

EID: 79551689038     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.12.035     Document Type: Article

References (15)

1. Takei Y., and Tsujimoto G. Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localisation J. Biol. Chem. 273 1998 22177 22180
2. Takei Y., Swietlik M., Tanoue A., Tsujimoto G., Kouzarides T., and Laskey R. MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3 EMBO Rep. 2 2001 119 123
3. Takei Y., Assenberg M., Tsujimoto G., and Laskey R. The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3 J. Biol. Chem. 277 2002 43121 43125
4. Abe E., Kuwahara K., Yoshida M., Suzuki M., Terasaki H., and Matsuo Y. Structure, expression and chromosomal localisation of the human gene encoding a germinal centre-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication Gene 255 2000 219 227
5. Fujimura S., Xing Y., Takeya M., Yamashita Y., Ohshima K., Kuwahara K., and Sakaguchi N. Increased expression of germinal center-associated nuclear protein RNA-primase is associated with lymphomagenesis Cancer Res. 65 2005 5925 5934
6. Kuwahara K., Fujimura S., Takahashi Y., Nakagata N., Takemori T., Aizawa S., and Sakaguchi N. Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses Proc. Natl Acad. Sci. 101 2004 1010 1015
7. Wickramasinghe V.O., McMurtrie P.I., Mills A.D., Takei Y., Penrhyn-Lowe S., and Amagase Y. mRNA export from mammalian cell nuclei is dependent on GANP Curr. Biol. 20 2010 25 31
8. Fischer T., Strasser K., Racz A., Rodriguez-Navarro S., Oppizzi M., and Ihrig P. The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores EMBO J. 21 2002 5843 5852
9. Ciccarelli F.D., Izaurralde E., and Bork P. The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold BMC Bioinformatics 4 2003 64
10. Faza M.B., Kemmler S., Jimeno S., Gonzalez-Aguilera C., Aguilera A., Hurt E., and Panse V.G. Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery J. Cell Biol. 184 2009 833 846
11. Jani D., Lutz S., Marshall N.J., Fischer T., Kohler A., and Ellisdon A.M. Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export Mol. Cell 33 2009 727 737
12. El-Gazzar M., Maeda K., Nomiyama H., Nakao M., Kuwahara K., and Sakaguchi N. PU.1 is involved in the regulation of B lineage-associated and developmental stage-dependent expression of the germinal center-associated DNA primase GANP J. Biol. Chem. 276 2001 48000 48008
13. Akira S. IL-6-regulated transcription factors Int. J. Biochem. Cell Biol. 29 1997 1401 1418
14. Baud V., and Karin M. Signal transduction by tumor necrosis factor and its relatives Trends Cell Biol. 11 2001 372 377
15. Odom D.T., Dowell R.D., Jacobsen E.S., Gordon W., Danford T.W., and MacIsaac K.D. Tissue-specific transcriptional regulation has diverged significantly between human and mouse Nat. Genet. 39 2007 730 732