Extent of spontaneous motor recovery after traumatic cervical sensorimotor complete spinal cord injury

Spinal Cord

Volumn 49, Issue 2, 2011, Pages 257-265

  Steeves, J D ^a   Kramer, J K ^a   Fawcett, J W ^b   Cragg, J ^a   Lammertse, D P ^c   Blight, A R ^d   Marino, R J ^e   Ditunno Jr , J F ^e   Coleman, W P ^f   Geisler, F H ^g   Guest, J ^h   Jones, L ⁱ   Burns, S ^j   Schubert, M ^k   Van Hedel, H J A ^k   Curt, A ^k  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c CRAIG HOSPITAL   (United States)

^d ACORDA THERAPEUTICS INC   (United States)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

^f WPC Math   (United States)

^g Rush Copley Medical Center   (United States)

^h UNIVERSITY OF MIAMI   (United States)

ⁱ GERON CORPORATION   (United States)

^j VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^k BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

more..

Author keywords

assessment; clinical trial; motor level; neurological recovery; outcomes; upper extremity motor score

Indexed keywords

ARTICLE; CERVICAL SPINAL CORD INJURY; CONVALESCENCE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR PERFORMANCE; MULTICENTER STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SENSORIMOTOR FUNCTION;

ADULT; DISABILITY EVALUATION; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MOVEMENT; QUADRIPLEGIA; RECOVERY OF FUNCTION; RETROSPECTIVE STUDIES; SPINAL CORD INJURIES;

EID: 79551682102     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sc.2010.99     Document Type: Article

References (31)

1. Fawcett JW, Curt A, Steeves JD, Coleman WP, Tuszynski MH, Lammertse D et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord 2007; 45: 190-205. (Pubitemid 46340848)
2. Steeves JD, Lammertse D, Curt A, Fawcett JW, Tuszynski MH, Ditunno JF et al. Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures. Spinal Cord 2007; 45: 206-221. (Pubitemid 46340849)
3. Tuszynski MH, Steeves JD, Fawcett JW, Lammertse D, Kalichman M, Rask C et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial inclusion/exclusion criteria and ethics. Spinal Cord 2007; 45: 222-231. (Pubitemid 46340850)
4. Lammertse D, Tuszynski MH, Steeves JD, Curt A, Fawcett JW, Rask C et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial design. Spinal Cord 2007; 45: 232-242. (Pubitemid 46340851)
5. Furlan JC, Fehlings MG, Tator CH, Davis AM. Motor and sensory assessment of patients in clinical trials for pharmacological therapy of acute spinal cord injury: psychometric properties of the ASIA Standards. J Neurotrauma 2008; 25: 1273-1301.
6. Geisler FH, Coleman WP, Grieco G, Poonian D. The Sygen multicenter acute spinal cord injury study. Spine (Phila Pa 1976) 2001; 26(24 Suppl): S87-S98.
7. Geisler FH, Coleman WP, Grieco G, Poonian D. Measurements and recovery patterns in a multicenter study of acute spinal cord injury. Spine (Phila Pa 1976) 2001; 26(24 Suppl): S68-S86. (Pubitemid 34019782)
8. Geisler FH, Coleman WP, Grieco G, Poonian D. Recruitment and early treatment in a multicenter study of acute spinal cord injury. Spine (Phila Pa 1976) 2001; 26(24 Suppl): S58-S67. (Pubitemid 34019781)
9. Curt A, van Hedel HJ, Klaus D, Dietz V. Recovery from a spinal cord injury: significance of compensation, neural plasticity, and repair. J Neurotrauma 2008; 25: 677-685.
10. Ditunno Jr JF, Cohen ME, Hauck WW, Jackson AB, Sipski ML. Recovery of upper-extremity strength in complete and incomplete tetraplegia: a multicenter study. Arch Phys Med Rehabil 2000; 81: 389-393.
11. Mange KC, Ditunno Jr JF, Herbison GJ, Jaweed MM. Recovery of strength at the zone of injury in motor complete and motor incomplete cervical spinal cord injured patients. Arch Phys Med Rehabil 1990; 71: 562-565.
12. Waters RL, Adkins RH, Yakura JS, Sie I. Motor and sensory recovery following complete tetraplegia. Arch Phys Med Rehabil 1993; 74: 242-247.
13. Waters RL, Adkins RH, Yakura JS, Sie I. Motor and sensory recovery following incomplete tetraplegia. Arch Phys Med Rehabil 1994; 75: 306-311. (Pubitemid 24099564)
14. Marino RJ, Ditunno Jr JF, Donovan WH, Maynard Jr F. Neurological recovery after traumatic spinal cord injury: data from the Model Spinal Cord Injury Systems. Arch Phys Med Rehabil 1999; 80: 1391-1396.
15. American Spinal Injury Association. Reference Manual of the International Standards for Neurological Classification of Spinal Cord Injury. American Spinal Injury Association: Chicago, IL, 2003 (www.asia-spinalinjury.org ).
16. Jakob W, Wirz M, van Hedel HJ, Dietz V. Difficulty of elderly SCI subjects to translate motor recoveryF'body function-Finto daily living activities. J Neurotrauma 2009; 26: 2037-2044.
17. Spiess MR, Muller RM, Rupp R, Schuld C, van Hedel HJ. Conversion in ASIA impairment scale during the first year after traumatic spinal cord injury. J Neurotrauma 2009; 26: 2027-2036.
18. van Hedel HJ, Curt A. Fighting for each segment: estimating the clinical value of cervical and thoracic segments in SCI. J Neurotrauma 2006; 23: 1621-1631.
19. van Hedel HJ, EMSCI Study Group. Gait speed in relation to categories of functional ambulation after spinal cord injury. Neurorehabil Neural Repair 2009; 23: 343-350.
20. van Hedel HJ, Dietz V. Walking during daily life can be validly and responsively assessed in subjects with a spinal cord injury. Neurorehabil Neural Repair 2009; 23: 117-124.
21. Wirth B, van Hedel HJ, Kometer B, Dietz V, Curt A. Changes in activity after a complete spinal cord injury as measured by the Spinal Cord Independence Measure II (SCIM II). Neurorehabil Neural Repair 2008; 22: 279-287. (Pubitemid 351972562)
22. Pinheiro JC, Bates DM. Linear Mixed Effects Models. Mixed Effects Models in S and S-Plus. Springer Verlag: New York, 2000.
23. Savic G, Bergstrom EM, Frankel HL, Jamous MA, Jones PW. Interrater reliability of motor and sensory examinations performed according to American Spinal Injury Association standards. Spinal Cord 2007; 45: 444-451.
24. Burns AS, Lee BS, Ditunno Jr JF, Tessler A. Patient selection for clinical trials: the reliability of the early spinal cord injury examination. J Neurotrauma 2003; 20: 477-482.
25. Kwon BK, Stammers AM, Belanger LM, Bernardo A, Chan D, Bishop et al. Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury. J Neurotrauma 2010; 27: 669-682.
26. Blight AR, Tuszynski MH. Clinical trials in spinal cord injury. J Neurotrauma 2006; 23: 586.
27. Rudhe C, van Hedel HJ. Upper extremity function in persons with tetraplegia: relationships between strength, capacity, and the spinal cord independence measure. Neurorehabil Neural Repair 2009; 23: 413.
28. Bromley I. Functional Independence. Tetraplegia and Paraplegia: A guide for physiotherapists, 6th edn. Elsevier: Philadelphia, PA, USA, 2006, p 397.
29. Shao J, Wang H, Chow SC. Large Sample Tests for Proportions. Sample Size Calculations in Clinical Research, Second ed. Edited by S. C. Chow Chapman and Hall, Boca Raton, FL, 2008, pp 83-115.
30. Shao J, Wang H, Chow SC. Comparing Means. Sample Size Calculations in Clinical Research, Second ed. edited by S. C. Chow Chapman and Hall, Boca Raton, FL, 2008, pp 49-81.
31. Ditunno JF. Outcome measures: evolution in clinical trials of neurological/functional recovery in spinal cord injury. Spinal Cord 2010; 48: 674-684.