Role of innate immunity in a murine model of histidyl-transfer RNA synthetase (Jo-1)-mediated myositis

Arthritis and Rheumatism

Volumn 63, Issue 2, 2011, Pages 479-487

  Soejima, Makoto ^a   Kang, Eun Ha ^b   Gu, Xinyan ^a   Katsumata, Yasuhiro ^c   Clemens, Paula R ^a   Ascherman, Dana P ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Seoul National University Bundang Hospital   (South Korea)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; B LYMPHOCYTE RECEPTOR; CARBOXYFLUORESCEIN; JO 1 ANTIBODY; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR 4;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; C3H MOUSE; C57BL 6 MOUSE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; INFLAMMATION; INNATE IMMUNITY; MALE; MYOSITIS; NONHUMAN; NONOBESE DIABETIC MOUSE; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE;

ADAPTIVE IMMUNITY; ANIMALS; B-LYMPHOCYTES; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; HISTIDINE-TRNA LIGASE; IMMUNITY, INNATE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; MYOSITIS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TIME FACTORS; TOLL-LIKE RECEPTOR 4;

EID: 79551668080     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30113     Document Type: Article

References (17)

1. Greenberg SA,. Inflammatory myopathies: disease mechanisms. Curr Opin Neurol 2009; 22: 516-23.
2. Suber TL, Casciola-Rosen L, Rosen A,. Mechanisms of disease: autoantigens as clues to the pathogenesis of myositis. Nat Clin Pract Rheumatol 2008; 4: 201-9.
3. Pignone A, Fiori G, Del Rosso A, Generini S, Matucci-Cerinic M,. The pathogenesis of inflammatory muscle diseases: on the cutting edge among the environment, the genetic background, the immune response and the dysregulation of apoptosis. Autoimmun Rev 2002; 1: 226-32.
4. Katsumata Y, Ascherman DP,. Animal models in myositis. Curr Opin Rheumatol 2008; 20: 681-5.
5. Nagaraju K, Plotz PH,. Animal models of myositis. Rheum Dis Clin North Am 2002; 28: 917-33.
6. Martin A, Shulman MJ, Tsui FW,. Epitope studies indicate that histidyl-tRNA synthetase is a stimulating antigen in idiopathic myositis. FASEB J 1995; 9: 1226-33.
7. Miller FW, Twitty SA, Biswas T, Plotz PH,. Origin and regulation of a disease-specific autoantibody response: antigenic epitopes, spectrotype stability, and isotype restriction of anti-Jo-1 autoantibodies. J Clin Invest 1990; 85: 468-75.
8. Miller FW, Waite KA, Biswas T, Plotz PH,. The role of an autoantigen, histidyl-tRNA synthetase, in the induction and maintenance of autoimmunity. Proc Natl Acad Sci U S A 1990; 87: 9933-7.
9. Raben N, Nichols R, Dohlman J, McPhie P, Sridhar V, Hyde C, et al. A motif in human histidyl-tRNA synthetase which is shared among several aminoacyl-tRNA synthetases is a coiled-coil that is essential for enzymatic activity and contains the major autoantigenic epitope. J Biol Chem 1994; 269: 24277-83.
10. Stone KB, Oddis CV, Fertig N, Katsumata Y, Lucas M, Vogt M, et al. Anti-Jo-1 antibody levels correlate with disease activity in idiopathic inflammatory myopathy. Arthritis Rheum 2007; 56: 3125-31.
11. Yoshida S, Akizuki M, Mimori T, Yamagata H, Inada S, Homma M,. The precipitating antibody to an acidic nuclear protein antigen, the Jo-1, in connective tissue diseases: a marker for a subset of polymyositis with interstitial pulmonary fibrosis. Arthritis Rheum 1983; 26: 604-11.
12. Ascherman DP,. The role of Jo-1 in the immunopathogenesis of polymyositis: current hypotheses. Curr Rheumatol Rep 2003; 5: 425-30.
13. Katsumata Y, Ridgway W, Oriss T, Gu X, Chin D, Wu Y, et al. Species-specific immune responses generated by histidyl-tRNA synthetase immunization are associated with muscle and lung inflammation. J Autoimmun 2007; 29: 174-86.
14. Wakasugi K, Schimmel P,. Two distinct cytokines released from a human aminoacyl-tRNA synthetase. Science 1999; 284: 147-51.
15. Howard OM, Dong HF, Yang D, Raben N, Nagaraju K, Rosen A, et al. Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells. J Exp Med 2002; 196: 781-91.
16. Henriques-Pons A, Nagaraju K,. Nonimmune mechanisms of muscle damage in myositis: role of the endoplasmic reticulum stress response and autophagy in the disease pathogenesis. Curr Opin Rheumatol 2009; 21: 581-7.
17. Nagaraju K, Raben N, Loeffler L, Parker T, Rochon PJ, Lee E, et al. Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies. Proc Natl Acad Sci U S A 2000; 97: 9209-14.