Over-expression of Gadd45a enhances radiotherapy efficacy in human Tca8113 cell line

Acta Pharmacologica Sinica

Volumn 32, Issue 2, 2011, Pages 253-258

  Zhang, Xiao Ying ^a,b   Qu, Xun ^a   Wang, Cheng Qin ^a   Zhou, Cheng Jun ^a   Liu, Gui Xiang ^a   Wei, Feng Cai ^b   Sun, Shan Zhen ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

apoptosis; Gadd45a; ionizing radiation; RNA interference; squamous cell carcinoma; Tca8113 cells

Indexed keywords

BETA ACTIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45A; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IONIZING RADIATION; RADIOSENSITIVITY; REAL TIME POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; TONGUE CARCINOMA; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; RADIATION, IONIZING; RNA, MESSENGER; RNA, SMALL INTERFERING; TONGUE NEOPLASMS; TRANSFECTION;

EID: 79551667665     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.208     Document Type: Article

References (31)

1. Rodrigues VC, Moss SM, Tuomainen H. Oral cancer in the UK: to screen or not to screen. Oral Oncol 1998; 34: 454-65.
2. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics, 2001. CA Cancer J Clin 2001; 51: 15-36.
3. Jackel MC, Ambrosch P, Christiansen H, Martin A, Steiner W. Value of postoperative radiotherapy in patients with pathologic N1 neck disease. Head Neck 2008; 30: 875-82.
4. Lal A, Gorospe M. Egad, more forms of gene regulation: the gadd45a story. Cell Cycle 2006; 5: 1422-5.
5. Fornace AJ Jr, Alamo I Jr, Hollander MC. DNA damage-inducible transcripts in mammalian cells. Proc Natl Acad Sci USA 1988; 85: 8800-4.
6. Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, et al. Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. Mol Cell Biol 1991; 11: 1009-16.
7. Hollander MC, Alamo I, Jackman J, Wang MG, McBride OW, Fornace AJ Jr. Analysis of the mammalian gadd45 gene and its response to DNA damage. J Biol Chem 1993; 268: 24385-93.
8. Shain SA. Exogenous fibroblast growth factors maintain viability, promote proliferation, and suppress GADD45alpha and GAS6 transcript content of prostate cancer cells genetically modified to lack endogenous FGF-2. Mol Cancer Res 2004; 2: 653-61.
9. 2. Free Radic Biol Med 2006; 41: 285-94.
10. Corn PG, El-Deiry WS. Microarray analysis of p53-dependent gene expression in response to hypoxia and DNA damage. Cancer Biol Ther 2007; 6: 1858-66.
11. Rosemary Siafakas A, Richardson DR. Growth arrest and DNA damage-45 alpha (GADD45alpha). Int J Biochem Cell Biol 2009; 41: 986-9.
12. Smith ML, Ford JM, Hollander MC, Bortnick RA, Amundson SA, Seo YR, et al. p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol Cell Biol 2000; 20: 3705-14.
13. Hollander MC, Sheikh MS, Bulavin DV, Lundgren K, Augeri-Henmueller L, Shehee R, et al. Genomic instability in Gadd45a-deficient mice. Nat Genet 1999; 23: 176-84.
14. Harkin DP, Bean JM, Miklos D, Song YH, Truong VB, Englert C, et al. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell 1999; 97: 575-86.
15. Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, DiStefano PS, et al. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 2002; 296: 530-4.
16. Tront JS, Hoffman B, Liebermann DA. Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence. Cancer Res 2006; 66: 8448-54.
17. Tong T, Ji J, Jin S, Li X, Fan W, Song Y, et al. Gadd45a expression induces Bim dissociation from the cytoskeleton and translocation to mitochondria. Mol Cell Biol 2005; 25: 4488-500.
18. Azria D, Larbouret C, Cunat S, Ozsahin M, Gourgou S, Martineau P, et al. Letrozole sensitizes breast cancer cells to ionizing radiation. Breast Cancer Res 2005; 7: R156-63.
19. D'Silva NJ, Ward BB. Tissue biomarkers for diagnosis & management of oral squamous cell carcinoma. Alpha Omegan 2007; 100: 182-9.
20. Palme CE, Gullane PJ, Gilbert RW. Current treatment options in squamous cell carcinoma of the oral cavity. Surg Oncol Clin N Am 2004; 13: 47-70.
21. Jang WI, Wu HG, Park CI, Kim KH, Sung MW, Kim MJ, et al. Treatment of patients with clinically lymph node-negative squamous cell carcinoma of the oral cavity. Jpn J Clin Oncol 2008; 38: 395-401.
22. Chambers MS, Garden AS, Kies MS, Martin JW. Radiation-induced xerostomia in patients with head and neck cancer: pathogenesis, impact on quality of life, and management. Head Neck 2004; 26: 796-807.
23. Benjamin CL, Melnikova VO, Ananthaswamy HN. P53 protein and pathogenesis of melanoma and nonmelanoma skin cancer. Adv Exp Med Biol 2008; 624: 265-82.
24. Daino K, Ichimura S, Nenoi M. Early induction of CDKN1A (p21) and GADD45 mRNA by a low dose of ionizing radiation is due to their dose-dependent post-transcriptional regulation. Radiat Res 2002; 157: 478-82.
25. Amundson SA, Lee RA, Koch-Paiz CA, Bittner ML, Meltzer P, Trent JM, et al. Differential responses of stress genes to low dose-rate gamma irradiation. Mol Cancer Res 2003; 1: 445-52.
26. Takekawa M, Saito H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 1998; 95: 521-30.
27. Perugini M, Kok CH, Brown AL, Wilkinson CR, Salerno DG, Young SM, et al. Repression of Gadd45alpha by activated FLT3 and GMCSF receptor mutants contributes to growth, survival and blocked differentiation. Leukemia 2009; 23: 729-38.
28. Zhang W, Hoffman B, Liebermann DA. Ectopic expression of MyD118/ Gadd45/CR6 (Gadd45beta/alpha/gamma) sensitizes neoplastic cells to genotoxic stress-induced apoptosis. Int J Oncol 2001; 18: 749-57.
29. Lu X, Yang C, Hill R, Yin C, Hollander MC, Fornace AJ Jr, et al. Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival. Cancer Res 2008; 68: 3579-83.
30. Zerbini LF, Libermann TA. GADD45 deregulation in cancer: frequently methylated tumor suppressors and potential therapeutic targets. Clin Cancer Res 2005; 11: 6409-13.
31. Al-Romaih K, Sadikovic B, Yoshimoto M, Wang Y, Zielenska M, Squire JA. Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells. Neoplasia 2008; 10: 471-80.