Wound healing/regeneration using recombinant human growth/differentiation factor-5 in an injectable poly-lactide-co-glycolide-acid composite carrier and a one-wall intra-bony defect model in dogs

Journal of Clinical Periodontology

Volumn 38, Issue 3, 2011, Pages 261-268

  Min, Cheon Ki ^a   Wikesjö, Ulf M E ^b   Park, Jung Chul ^a   Chae, Gyung Joon ^a   Pippig, Susanne D ^c   Bastone, Patrizia ^c   Kim, Chang Sung ^a   Kim, Chong Kwan ^a  

^a Yonsei University College of Dentistry   (South Korea)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c Scil Technology GmbH   (Germany)

Author keywords

dog; periodontal regeneration; PLGA; rhGDF 5; tissue engineering

Indexed keywords

BIOMATERIAL; DRUG CARRIER; GROWTH DIFFERENTIATION FACTOR 5; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; RECOMBINANT PROTEIN;

ALVEOLAR BONE LOSS; ANIMAL; ARTICLE; BIODEGRADABLE IMPLANT; BONE DEVELOPMENT; CEMENTUM; CHEMISTRY; COMPARATIVE STUDY; CONNECTIVE TISSUE; DOG; DOSE RESPONSE; DRUG EFFECT; EPITHELIUM; HUMAN; JAW; MALE; METHODOLOGY; PATHOLOGY; PERIODONTICS; RANDOMIZATION; REGENERATION; TIME; TOOTH DEVELOPMENT; WOUND HEALING;

ABSORBABLE IMPLANTS; ALVEOLAR BONE LOSS; ALVEOLAR PROCESS; ANIMALS; BIOCOMPATIBLE MATERIALS; CEMENTOGENESIS; CONNECTIVE TISSUE; DENTAL CEMENTUM; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; EPITHELIUM; GROWTH DIFFERENTIATION FACTOR 5; GUIDED TISSUE REGENERATION, PERIODONTAL; HUMANS; LACTIC ACID; MALE; OSTEOGENESIS; POLYGLYCOLIC ACID; RANDOM ALLOCATION; RECOMBINANT PROTEINS; REGENERATION; TIME FACTORS; WOUND HEALING;

EID: 79551662404     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2010.01691.x     Document Type: Article

References (48)

1. Chang, S. C., Hoang, B., Thomas, J. T., Vukicevic, S., Luyten, F. P., Ryba, N. J., Kozak, C. A., Reddi, A. H., &, Moos, M Jr., (1994) Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. The Journal of Biological Chemistry 269, 28227-28234.
2. Choi, S. H., Kim, C. K., Cho, K. S., Huh, J. S., Sorensen, R. G., Wozney, J. M., &, Wikesjö, U. M. E., (2002) Effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) on healing in 3-wall intrabony defects in dogs. Journal of Periodontology 73, 63-72.
3. Giannobile, W. V., Ryan, S., Shih, M. S., Su, D. L., Kaplan, P. L., &, Chan, T. C., (1998) Recombinant human osteogenic protein-1 (OP-1) stimulates periodontal wound healing in class III furcation defects. Journal of Periodontology 69, 129-137.
4. Herberg, S., Siedler, M., Pippig, S., Schuetz, A., Dony, C., Kim, C-K., &, Wikesjö, U. M. E., (2008) Development of an injectable composite as a carrier for growth factor enhanced periodontal regeneration. Journal of Clinical Periodontology 35, 976-984.
5. Hötten, G., Neidhardt, H., Jacobowsky, B., &, Pohl, J., (1994) Cloning and expression of recombinant human growth/differentiation factor 5. Biochemical and Biophysical Research Communications 204, 646-652.
6. Hötten, G. C., Matsumoto, T., Kimura, M., Bechtold, R. F., Kron, R., Ohara, T., Tanaka, H., Satoh, Y., Okazaki, M., Shirai, T., Pan, H., Kawai, S., Pohl, J. S., &, Kudo, A., (1996) Recombinant human growth/differentiation factor 5 stimulates mesenchyme aggregation and chondrogenesis responsible for the skeletal development of limbs. Growth Factors 13, 65-74.
7. Isobe, M., Yamazaki, Y., Oida, S., Ishihara, K., Nakabayashi, N., &, Amagasa, T., (1996) Bone morphogenetic protein encapsulated with a biodegradable and biocompatible polymer. Journal of Biomedical Materials Research 32, 433-438.
8. Kenley, R., Marden, L., Turek, T., Jin, L., Ron, E., &, Hollinger, J. O., (1994) Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenetic protein-2 (rhBMP-2). Journal of Biomedical Materials Research 28, 1139-1147.
9. Kim, C. S., Choi, S. H., Chai, J. K., Cho, K. S., Moon, I. S., Wikesjö, U. M. E., &, Kim, C. K., (2004) Periodontal repair in surgically created intrabony defects in dogs: influence of the number of bone walls on healing response. Journal of Periodontology 75, 229-235.
10. Kim, C. S., Choi, S. H., Cho, K. S., Chai, J. K., Wikesjö, U. M. E., &, Kim, C. K., (2005) Periodontal healing in one-wall intra-bony defects in dogs following implantation of autogenous bone or a coral-derived biomaterial. Journal of Clinical Periodontology 32, 583-589.
11. Kim, T. G., Wikesjö, U. M. E., Cho, K. S., Chai, J. K., Pippig, S. D., Siedler, M., &, Kim, C. K., (2009) Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor-5 (rhGDF-5) in an absorbable collagen sponge carrier into one-wall intrabony defects in dogs: a dose-range study. Journal of Clinical Periodontology 36, 589-597.
12. Koch, F. P., Becker, J., Terheyden, H., Capsius, B., &, Wagner, W., (2010) A prospective, randomized pilot study on the safety and efficacy of recombinant human growth and differentiation factor-5 coated onto b-tricalcium phosphate for sinus lift augmentation. Clinical Oral Implants Research 21, 1301-1308.
13. Kuniyasu, H., Hirose, Y., Ochi, M., Yajima, A., Sakaguchi, K., Murata, M., &, Pohl, J., (2003) Bone augmentation using rhGDF-5-collagen composite. Clinical Oral Implants Research 14, 490-499.
14. Kwon, D. H., Bennett, W., Herberg, S., Bastone, P., Pippig, S., Rodriguez, N. A., &, Wikesjö, U. M. E., (2010a) Evaluation of an injectable rhGDF-5/PLGA construct for minimally invasive periodontal regenerative procedures: a histological study in the dog. Journal of Clinical Periodontology 37, 390-397.
15. Kwon, D. H., Bisch, F. C., Herold, R. W., Pompe, C., Bastone, P., Rodriguez, N. A., Susin, C., &, Wikesjö, U. M. E., (2010b) Periodontal wound healing/regeneration following application of rhGDF-5 in a β-TCP/PLGA carrier in critical-size supraalveloar periodontal defects in dogs. Journal of Clinical Periodontology 37, 667-674.
16. Kwon, H-R., Wikesjö, U. M. E., Jung, U-W., Kim, Y-T., Bastone, P., Pippig, S. D., &, Kim, C-K., (2010c) Growth/differentiation factor-5 significantly enhances periodontal wound healing/regeneration compared with platelet derived growth factor-BB in dogs. Journal of Clinical Periodontology 2010 37, 739-746.
17. Lee, J., Stavropoulos, A., Susin, C., &, Wikesjö, U. M. E., (2010a) Periodontal regeneration: focus on growth and differentiation factors. Dental Clinics of North America 54, 93-111.
18. Lee, J-S., Wikesjö, U. M. E., Jung, U-W., Choi, S-H., Pippig, S., Siedler, M., &, Kim, C-K., (2010b) Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor-5 in a β-tricalcium phosphate carrier into one-wall intrabony defects in dogs. Journal of Clinical Periodontology 37, 382-389.
19. Lindskog, S., &, Blomlöf, L., (1992) Mineralized tissue-formation in periodontal wound healing. Journal of Clinical Periodontology 19, 741-748.
20. Miyaji, H., Sugaya, T., Kato, K., Kawamura, N., Tsuji, H., &, Kawanami, M., (2006) Dentin resorption and cementum-like tissue formation by bone morphogenetic protein application. Journal of Periodontal Research 41, 311-315.
21. Moore, Y., Dickinson, D. P., &, Wikesjö, U. M. E., (2010) Growth/differentiation factor-5 (GDF-5): a candidate therapeutic agent for periodontal regeneration? Review of preclinical data. Journal of Clinical Periodontology 37, 288-298.
22. Morotome, Y., Goseki-Sone, M., Ishikawa, I., &, Oida, S., (1998) Gene expression of growth and differentiation factors-5, -6, and -7 in developing bovine tooth at the root forming stage. Biochemical and Biophysical Research Communications 244, 85-90.
23. Nakamura, T., Yamamoto, M., Tamura, M., &, Izumi, Y., (2003) Effects of growth/differentiation factor-5 on human periodontal ligament cells. Journal of Periodontal Research 38, 597-605.
24. Pöhling, S., Pippig, S. D., Hellerbrand, K., Siedler, M., Schutz, A., &, Dony, C., (2006) Superior effect of MD05, beta-tricalcium phosphate coated with recombinant human growth/differentiation factor-5, compared to conventional bone substitutes in the rat calvarial defect model. Journal of Periodontology 77, 1582-1590.
25. Polimeni., G., Xiropaidis., A. V., &, Wikesjö, U. M. E., (2006) Biology and principles of periodontal wound healing/regeneration. Periodontology 2000 41, 30-47.
26. Pompe, C., (2008) Development of New In-Situ Hardening and Bioactivated Composite Materials for Orthopedic Indications. M ü nchen: Universität München.
27. Reddi, A. H., (1992) Regulation of cartilage and bone differentiation by bone morphogenetic proteins. Current Opinion in Cell Biology 4, 850-855.
28. Ripamonti, U., Crooks, J., Petit, J. C., &, Rueger, D. C., (2001) Periodontal tissue regeneration by combined applications of recombinant human osteogenic protein-1 and bone morphogenetic protein-2. A pilot study in Chacma baboons (Papio ursinus). European Journal of Oral Sciences 109, 241-248.
29. Ripamonti, U., Crooks, J., Teare, J., Petit, J. C., &, Rueger, D. C., (2002) Periodontal tissue regeneration by recombinant human osteogenic protein-1 in periodontally-induced furcation defects of the primate Papio ursinus. South African Journal of Science 98, 361-368.
30. Ripamonti, U., Heliotis, M., Rueger, D. C., &, Sampath, T. K., (1996) Induction of cementogenesis by recombinant human osteogenic protein-1 (hop-1/bmp-7) in the baboon (Papio ursinus). Archives of Oral Biology 41, 121-126.
31. Ripamonti, U., Heliotis, M., van den Heever, B., &, Reddi, A. H., (1994) Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio ursinus). Journal of Periodontal Research 29, 439-445.
32. Saito, E., Saito, A., &, Kawanami, M., (2003) Favorable healing following space creation in rhBMP-2-induced periodontal regeneration of horizontal circumferential defects in dogs with experimental periodontitis. Journal of Periodontology 74, 1808-1815.
33. Selvig, K. A., Sorensen, R. G., Wozney, J. M., &, Wikesjö, U. M. E., (2002) Bone repair following recombinant human bone morphogenetic protein-2 stimulated periodontal regeneration. Journal of Periodontology 73, 1020-1029.
34. Sena, K., Morotome, Y., Baba, O., Terashima, T., Takano, Y., &, Ishikawa, I., (2003) Gene expression of growth differentiation factors in the developing periodontium of rat molars. Journal of Dental Research 82, 166-171.
35. Shen, F. H., Zeng, Q., Lv, Q., Choi, L., Balian, G., Li, X., &, Laurencin, C. T., (2006) Osteogenic differentiation of adipose-derived stromal cells treated with GDF-5 cultured on a novel three-dimensional sintered microsphere matrix. The Spine Journal 6, 615-623.
36. Sigurdsson, T. J., Hardwick, R., Bogle, G. C., &, Wikesjö, U. M. E., (1994) Periodontal repair in dogs: space provision by reinforced ePTFE membranes enhances bone and cementum regeneration in large supraalveolar defects. Journal of Periodontology 65, 350-356.
37. Sigurdsson, T. J., Lee, M. B., Kubota, K., Turek, T. J., Wozney, J. M., &, Wikesjö, U. M. E., (1995) Periodontal repair in dogs: recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration. Journal of Periodontology 66, 131-138.
38. Sigurdsson, T. J., Nygaard, L., Tatakis, D. N., Fu, E., Turek, T. J., Jin, L., Wozney, J. M., &, Wikesjö, U. M. E., (1996) Periodontal repair in dogs: evaluation of rhBMP-2 carriers. The International Journal of Periodontics and Restorative Dentistry 16, 524-537.
39. Uludag, H., D'Augusta, D., Golden, J., Li, J., Timony, G., Riedel, R., &, Wozney, J. M., (2000) Implantation of recombinant human bone morphogenetic proteins with biomaterial carriers: a correlation between protein pharmacokinetics and osteoinduction in the rat ectopic model. Journal of Biomedical Materials Research 50, 227-238.
40. Urist, M. R., (1965) Bone: formation by autoinduction. Science 150, 893-899.
41. Wikesjö, U. M. E., Guglielmoni, P., Promsudthi, A., Cho, K. S., Trombelli, L., Selvig, K. A., Jin, L., &, Wozney, J. M., (1999) Periodontal repair in dogs: effect of rhBMP-2 concentration on regeneration of alveolar bone and periodontal attachment. Journal of Clinical Periodontology 26, 392-400.
42. Wikesjö, U. M. E., Lim, W. H., Thomson, R. C., Cook, A. D., Wozney, J. M., &, Hardwick, W. R., (2003c) Periodontal repair in dogs: evaluation of a bioresorbable space-providing macro-porous membrane with recombinant human bone morphogenetic protein-2. Journal of Periodontology 74, 635-647.
43. Wikesjö, U. M. E., Sorensen, R. G., Kinoshita, A., Jian Li, X., &, Wozney, J. M., (2004) Periodontal repair in dogs: effect of recombinant human bone morphogenetic protein-12 (rhBMP-12) on regeneration of alveolar bone and periodontal attachment. Journal of Clinical Periodontology 31, 662-670. (Pubitemid 39092230)
44. Wikesjö, U. M. E., Xiropaidis, A. V., Thomson, R. C., Cook, A. D., Selvig, K. A., &, Hardwick, W. R., (2003a) Periodontal repair in dogs: rhBMP-2 significantly enhances bone formation under provisions for guided tissue regeneration. Journal of Clinical Periodontology 30, 705-714.
45. Wikesjö, U. M. E., Xiropaidis, A. V., Thomson, R. C., Cook, A. D., Selvig, K. A., &, Hardwick, W. R., (2003b) Periodontal repair in dogs: space-providing ePTFE devices increase rhBMP-2/ACS-induced bone formation. Journal of Clinical Periodontology 30, 715-725.
46. Wozney, J. M., Rosen, V., Celeste, A. J., Mitsock, L. M., Whitters, M. J., Kriz, R. W., Hewick, R. M., &, Wang, E. A., (1988) Novel regulators of bone formation: molecular clones and activities. Science 242, 1528-1534.
47. Yamashita, H., Shimizu, A., Kato, M., Nishitoh, H., Ichijo, H., Hanyu, A., Morita, I., Kimura, M., Makishima, F., &, Miyazono, K., (1997) Growth/differentiation factor-5 induces angiogenesis in vivo. Experimental Cell Research 235, 218-226.
48. Zeng, Q., Li, X., Beck, G., Balian, G., &, Shen, F. H., (2007) Growth and differentiation factor-5 (GDF-5) stimulates osteogenic differentiation and increases vascular endothelial growth factor (VEGF) levels in fat-derived stromal cells in vitro. Bone 40, 374-381.