Cytotoxicity of four ophthalmic solutions containing nipradilol for one conjunctival and three corneal cell lines

Folia Japonica de Ophthalmologica Clinica

Volumn 3, Issue 12, 2010, Pages 1245-1249

  Yamaguchi, Daisuke ^a   Ayaki, Masahiko ^b   Yaguchi, Shigeo ^a   Koide, Ryohei ^a   Iwasawa, Atsuo ^c  

^a SHOWA UNIVERSITY   (Japan)

^b SAITAMA NATIONAL HOSPITAL   (Japan)

^c SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

Author keywords

Benzalkonium chloride; Conjunctiva; Cornea; Glaucoma; Nipradilol

Indexed keywords

EID: 79551648301     PISSN: 18825176     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Kanno M, Araie M, et al: Effects of topical nipradilol, a betablocking agent with alpha-blocking and nitroglycerin-like activities, on aqueous humor dynamics and fundus circulation. Invest Ophthalmol Vis Sci 39: 736-743, 1998. (Pubitemid 28207468)
2. Mizuno K, Koide T, et al: Topical nipradilol: effects on optic nerve head circulation in humans and periocular distribution in monkeys. Invest Ophthalmol Vis Sci 43: 3243-3250, 2002.
3. Mizuno K, Koide T, et al: Neuroprotective effect and intraocular penetration of nipradilol, a beta-blocker with nitric oxide donative action. Invest Ophthalmol Vis Sci 42: 688694, 2001.
4. Kanno M, Araie M, et al: Effects of topical nipradilol, a beta blocking agent with alpha blocking and nitroglycerin-like activities, on intraocular pressure and aqueous dynamics in humans. Br J Ophthalmol 84: 293-299, 2000. (Pubitemid 30251686)
5. Pfister RR, Burstein NL: The effects of ophthalmic drugs, vehicles, and preservatives on corneal epithelium: a scanning electron microscope study. Invest Ophthalmol. Invest Ophthalmol Vis Sci 15: 246-259, 1976.
6. De Saint Jean, F Brignole, et al: Effects of benzalkonium chloride on growth and survival of Chang conjunctival cells. Invest Ophthalmol Vis Sci 40: 619-630, 1999. (Pubitemid 29109440)
7. Hubbard SA: Comparative toxicology of borates. Biol Trace Elem Res 66: 343-357, 1998.
8. Epstein SP, Ahdoot M, et al: Comparative toxicity of preservatives on immortalized corneal and conjunctival epithelial cells. J Ocul Pharmacol Ther 25: 113-119, 2009.
9. Miyake K, Ota I, et al: Latanoprost accelerates disruption of the blood-aqueous barrier and the incidence of angiographic cystoid macular edema in early postoperative pseudophakias. Arch Ophthalmol 117: 34-40, 1999. (Pubitemid 29056717)