Benign and malignant tumors in Down syndrome: Analysis of the 1514 autopsied cases in Japan

Pediatrics International

Volumn 53, Issue 1, 2011, Pages 72-77

  Ehara, Hiroaki ^a,b   Ohno, Kousaku ^b   Ito, Hisao ^c  

^a SHIGA UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

Author keywords

autopsy; benign tumor; Down syndrome; Japan; malignant tumor

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; AUTOPSY; BENIGN TUMOR; BILE DUCT CARCINOMA; BRAIN TUMOR; CHILD; CHRONIC MYELOID LEUKEMIA; COLON TUMOR; DISEASE ASSOCIATION; DOWN SYNDROME; FEMALE; GALLBLADDER CARCINOMA; HEMATOLOGIC MALIGNANCY; HUMAN; INFANT; JAPAN; LIVER CELL CARCINOMA; MALE; MALIGNANT NEOPLASTIC DISEASE; PRIORITY JOURNAL; SEMINOMA; SOLID TUMOR;

ADOLESCENT; ADULT; AUTOPSY; CHILD; CHILD, PRESCHOOL; DOWN SYNDROME; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; JAPAN; MALE; MIDDLE AGED; NEOPLASMS; YOUNG ADULT;

EID: 79551647855     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/j.1442-200X.2010.03189.x     Document Type: Article

References (25)

1. Robison LL, Nesbit ME Jr, Sather HN, et al. Down syndrome and acute leukemia in children: A 10-year retrospective survey from Children's Cancer Study Group. J. Pediatr. 1984; 105: 235-42. (Pubitemid 14060212)
2. Patja K, Pukkala E, Sund R, Iivanainen M, Kaski M,. Cancer incidence of persons with Down syndrome in Finland: A population-based study. Int. J. Cancer 2006; 118: 1769-72. (Pubitemid 43376441)
3. Daneshpazhooh M, Nazemi TM, Bigdeloo L, Yoosefi M,. Mucocutaneous findings in 100 children with Down syndrome. Pediatr. Dermatol. 2007; 24: 317-20. (Pubitemid 46848962)
4. Butterworth T, Strean LP, Beerman H, Wood MG,. Syringoma and mongolism. Arch. Dermatol. 1964; 90: 482-7.
5. Satgé D, Sommelet D, Geneix A, Nishi M, Malet P, Vekemans M,. A tumor profile in Down syndrome. Am. J. Med. Genet. 1998; 78: 207-16. (Pubitemid 28307532)
6. Satgé D, Sasco AJ, Vekemans MJ, Portal ML, Fléjou JF,. Aspects of digestive tract tumors in Down syndrome: A literature review. Dig. Dis. Sci. 2006; 51: 2053-61.
7. Pimentel J, Fernandes A, Távora L, Miguéns J, Lobo Antunes J,. Benign isolated fibrohistiocytic tumor arising from the central nervous system. Clin. Neuropathol. 2002; 21: 93-8. (Pubitemid 34496017)
8. Togawa Y, Nohira G, Shinkai H, Utani A,. Collagenoma in Down syndrome. Br. J. Dermatol. 2003; 148: 596-7.
9. Hasle H, Clemmensen IH, Mikkelsen M,. Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet 2000; 355: 165-9. (Pubitemid 30068214)
10. Hasle H,. Pattern of malignant disorders in individuals with Down's syndrome. Lancet Oncol. 2001; 2: 429-36. (Pubitemid 33585947)
11. Zipursky A, Thorner P, de Harven E, Christensen H, Doyle J,. Myelodysplasia and acute megakaryoblastic leukemia in Down's syndrome. Leuk. Res. 1994; 18: 163-71. (Pubitemid 24127571)
12. Hasle H, Kerndrop G, Jacobsen BB,. Childhood myelodysplastic syndrome in Denmark: Incidence and predisposing conditions. Leukemia 1995; 9: 1569-72.
13. Fong CT, Brodeur GM,. Down's syndrome and leukemia: Epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis. Cancer Genet. Cytogenet. 1987; 28: 55-76. (Pubitemid 17153555)
14. Eckrich MJ, Domm J, Ho R, Whitlock JA, Frangoul H,. Autologous stem cell transplant in a patient with Down syndrome and relapsed Hodgkin lymphoma. Pediatr. Blood Cancer 2009; 53: 1327-8.
15. Goubin A, Auclerc MF, Auvrignon A, et al. Survival in France after childhood acute leukaemia and non-Hodgkin's lymphoma (1990-2000). Eur. J. Cancer 2006; 42: 534-41. (Pubitemid 43227934)
16. Fraumeni JF Jr, Miller RW, Hill JA,. Primary carcinoma of the liver in childhood: An epidemiologic study. J. Natl. Cancer Inst. 1968; 40: 1087-99.
17. Mukhopadhyay P, Kundu SS, Banerjee A, Mukherjee A,. Adult hepatoblastoma in a female Down's. J. Assoc. Physicians India 2007; 55: 242-3.
18. Boker LK, Merrick J,. Cancer incidence in persons with Down syndrome in Israel. Downs Syndr. Res. Pract. 2002; 8: 31-6.
19. Morgan JR,. A case of Down's syndrome, insulinoma and anorexia. J. Ment. Defic. Res. 1989; 33: 185-7. (Pubitemid 19116272)
20. de Weerdt CJ, Schut T,. Some aspects of heredity of brain tumours. Psychiatr. Neurol. Neurochir. 1972; 75: 293-8.
21. Scholl T, Stein Z, Hansen H,. Leukemia and other cancers, anomalies and infections as causes of death in Down's syndrome in the United States during 1976. Dev. Med. Child Neurol. 1982; 24: 817-29. (Pubitemid 13250730)
22. Narod SA, Stiller C, Lenoir GM,. An estimate of the heritable fraction of childhood cancer. Br. J. Cancer 1991; 63: 993-9.
23. Nishi M, Miyake H, Takeda T, Hatae Y,. Congenital malformations and childhood cancer. Med. Pediatr. Oncol. 2000; 34: 250-4. (Pubitemid 30176600)
24. Satgé D, Monteil P, Sasco AJ, et al. Aspects of intracranial and spinal tumors in patients with Down syndrome and report of a rapidly progressing Grade 2 astrocytoma. Cancer 2001; 91: 1458-66. (Pubitemid 32319256)
25. Satgé D, Sasco AJ, Curé H, Leduc B, Sommelet D, Vekemans MJ,. An excess of testicular germ cell tumors in Down's syndrome: Three case reports and a review of the literature. Cancer 1997; 80: 929-35. (Pubitemid 27360475)