Expression of hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN4) is increased in hypertrophic cardiomyopathy

Cardiovascular Pathology

Volumn 20, Issue 2, 2011, Pages 110-113

  Wei Qing, Huang ^a   Qing Nuan, Kong ^a   Lin, Xu ^a   Cheng Hao, Guo ^b   Qi Yi, Zhang ^a  

^a QINGDAO MUNICIPAL HOSPITAL   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

FQ RT PCR; Gene expression; HCN4; Hypertrophic cardiomyopathy; Sudden death

Indexed keywords

CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CATION CHANNEL 4; MESSENGER RNA; METOPROLOL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUTOPSY; CASE REPORT; CONTROLLED STUDY; FEMALE; FIBROSING ALVEOLITIS; FLUORESCENCE; GENE DOSAGE; GENE EXPRESSION; HEART LEFT VENTRICLE; HEART MUSCLE; HUMAN; HUMAN TISSUE; HYPERTROPHIC CARDIOMYOPATHY; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRAFFIC ACCIDENT;

ADULT; CARDIOMYOPATHY, HYPERTROPHIC; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; FEMALE; GENE EXPRESSION; HUMANS; MALE; MUSCLE PROTEINS; MYOCARDIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

EID: 79551595326     PISSN: 10548807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carpath.2010.01.007     Document Type: Article

References (16)

1. Accili EA, Proenza C, and Baruscotti M From funny current to HCN channels: 20 years of excitation News Physiol Sci 17 1 2002 32 37
2. Richard RB, and Sie gelbaum SA Hyperpolarization-activated cation currents: from molecules to physiological function Annu Revi Physiol 65 1 2003 453 480
3. Chen J, Piper DR, and Sanguinetti MC Voltage sensing and activation gating of HCN pacemaker channels Trends Cardiovasc Med 12 1 2002 42 45
4. Ludwig A, Zong X, and Hofmann F Structure and function of cardiac pacemaker channels Cell Physiol Biochem 9 4-5 1999 179 186
5. Fernández-Velasco M, Goren N, and Goern N Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts J Physiol 553 Pt2 2003 395 405
6. Zhang Jing Y, and Li Suo Y Pathology study of cardiac sudden death in the adolescent adults J ChiFeng College 23 2007 92 94
7. Song Yi X, and Yao Qing S The cardiac conduction system disorders in six hypertrophic cardiomyopathy patients J Chinese Forensic 12 1997 112 114
8. Cerbai E, Barbieri M, and Mugelli A Occurrence and properties of the hyperpolarization-activated current If in ventricular myocytes from normal and hypertensive rats during aging Circulation 94 1996 1674 1681
9. Biel M, Ludwig A, and Zong X Hyperpolarization-activated cation channels: a multigene family Rev Physiol Biochem Pharmacol 136 1 1999 165 181
10. Biel M, Schneider A, and Wahl C Cardiac HCN channels: structure, function, and modulation Trends Cardiovasc Med 2 5 2002 206 213
11. Bender RA, Soleymani SV, and Brewster AL Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus J Neurosci 23 17 2003 682 686
12. Stieber J, Herrmann S, and Feil S The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart Proc Natl Acad Sci USA 100 25 2003 15235 15240
13. Zagotta WN, Olivier NB, and Black KD Structural basis for modulation and agonist specificity of HCN pacemaker channels Nature 425 6954 2003 200 205
14. Schulze-Bahr E, Neu A, and Friederich P Pacemaker channel dysfunction in a patient with sinus node disease J Clin Invest 111 10 2003 1537 1545
15. Stillitano F, Lonardo G, and Zicha S Molecular basis of funny current (If) in normal and failing human heart J Mol Cell Cardiol 45 2 2008 289 299
16. Barbieri M, Varani K, and Cerbai E Electrophysiological basis for the enhanced cardiac arrhythmogenic effect of isoprenaline in aged spontaneously hypertensive rats J Mol Cell Cardiol 26 7 1994 849 860