Modulation of immune response by Vernonia cinerea L. inhibits the proinflammatory cytokine profile, iNOS, and COX-2 expression in LPS-stimulated macrophages

Immunopharmacology and Immunotoxicology

Volumn 33, Issue 1, 2011, Pages 73-83

  Pratheeshkumar, P ^a   Kuttan, Girija ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

COX 2; immunomodulation; iNOS; proinflammatory cytokines; Vernonia cinerea L

Indexed keywords

ALPHA ESTERASE; CYCLOOXYGENASE 2; ESTERASE; IMMUNOMODULATING AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; PLANT EXTRACT; UNCLASSIFIED DRUG; VERNONIA CINEREA EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DOWN REGULATION; IMMUNE RESPONSE; IMMUNOMODULATION; LEUKOCYTE COUNT; LYMPHOCYTE TRANSFORMATION; MACROPHAGE; MOUSE; NONHUMAN; ORGAN WEIGHT; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEEP ERYTHROCYTE; SPLEEN CELL; THYMOCYTE; VERNONIA; VERNONIA CINEREA;

ANIMALS; ANTIBODIES; ANTIBODY-PRODUCING CELLS; BONE MARROW CELLS; CYCLOOXYGENASE 2; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; IMMUNOLOGIC FACTORS; LEUKOCYTES; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; NITRIC OXIDE SYNTHASE TYPE II; ORGAN SIZE; PLANT EXTRACTS; SPLEEN; THYMUS GLAND; VERNONIA;

MUS; OVIS ARIES; VERNONIA CINEREA;

EID: 79551591905     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923971003745977     Document Type: Article

References (40)

1. Kuby, J. Immunology, 3rd ed. New York: WH. Freeman and Company; 1997.
2. Hersh, E.M., Freiriech, EJ. Methods in Cancer Research. New York, NY: Academic press; 1969.
3. Manesh, C, Kuttan, G. Efect of naturally occurring iso-thiocyanates on the immune system. Immunopharmacol. Immunotoxicol. 2003, 25, 451-9.
4. Nathan, C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992, 6, 3051-64.
5. Moncada, S. Nitric oxide: discovery and impact on clinical medi-cine. J. R. Soc Med. 1999, 92, 164-9.
6. Palmer, R.M., Ashton, D.S., Moncada, S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988, 333, 664-6.
7. Hibbs, J.B. Jr, Taintor, R.R., Vavrin, Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science 1987, 235, 473-6.
8. Payvandi, F., Wu, L., Haley, M., Schafer, P.H., Zhang, L.H., Chen, R.S., Muller, G.W., Stirling, D.I. Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. Cell. Immunol. 2004, 230, 81-8.
9. Bondeson, J. Te mechanisms of action of disease-modifying antirheumatic drugs: a review with emphasis on macrophage signal transduction and the induction of proinfammatory cytokines. Gen. Pharmacol. 1997, 29, 127-50.
10. Andreakos, E., Foxwell, B., Feldmann, M. Is targeting Toll-like receptors and their signaling pathway a useful therapeu-tic approach to modulating cytokine-driven infammation? Immunol. Rev. 2004, 202, 250-65.
11. Duke, J.A. CRC Handbook of Medicinal Herbs. CRC Press International Inc.; 1985.
12. Kuttan, G., Kuttan, R. Immunomodulatory activity of a peptide isolated from Viscum album extract (NSC 635 089). Immunol. Invest. 1992, 21, 285-96.
13. Mathew, S., Kuttan, G. Immunomodulatory and anti tumor activ-ities of Tinospora cordifolia. Fitoterapia. 1999, 70, 35-43.
14. Davis, L., Kuttan, G. Efect of Withania somnifera on cyclophos-phamide- induced urotoxicity. Cancer Lett. 2000, 148, 9-17.
15. Sunila, E.S., Kuttan, G. Immunomodulatory and antitumor activ-ity of Piper longum Linn. and piperine. J. Ethnopharmacol. 2004, 90, 339-46.
16. Hsu, YT. Study on the Chinese drugs used as a cancer remedy. JSE Asian Res. 1967, 3, 63.
17. John, D. One hundred useful raw drugs of the Kani tribes of Trivandrum. Inter. J. Crude Drug Res. 1984, 1, 17-39.
18. Jain, S.P., Puri, H.S. Ethnomedicinal plants of Jaunsar-Bawar hills, Uttar Pradesh, India. J. Ethnopharmacol. 1984, 12, 213-22.
19. Singh, V.K., Ali, Z.A. Folk medicines of Aligarh (Uttar Pradesh) India. Fitoterapia. 1989, LX, 483-490.
20. Bhattarai, N.K. Folk herbal medicines of Makawanpur district, Nepal. Inter J Pharmacog. 1991, 29, 284-295.
21. Bajpai, A., Ohja, J.K., Sant, H.R. Medicobotany of the Varanasi District. Inter J Pharmacog. 1995, 33, 172-176.
22. Graigner, C.R. Medicinal plants of Seychelles. J Royal Soc Health. 1996, 116, 107-109.
23. Abeysekera, A.M., DeSilva, K.Y.D., DeSilva, S.R.P., Sirimanne, V.D.P., Labadie, R.P., VanderBerg, A.J.J., et al. Inhibition of chemiluminescence generated by zymosan-activated polymorphonuclear leucocytes by phenolic constitu-ents of Vernonia cinerea. Fitoterapia. 1999, 70, 317.
24. Hall, I.H., Lee, K.H., Starnes, C.O., Sumida, Y., Wu, RY., Waddell, T.G., Cochran, J.W., Gerhart, K.G. Anti-infammatory activity of sesquiterpene lactones and related compounds. J. Pharm. Sci. 1979, 68, 537-42.
25. Jakupovic, J., Banerjee, S., Castro, V., Bohlmann, F., Schuster, A., Msonthi, J.D., et al. Poskeanolide, a seco-germacranolide and other sesquiterpene lactones from Vernonia species. Phytochemistry. 1986, 25, 1359.
26. Misra, T.N., Singh, R.S., Srivastava, R., Pandey, H.S., Prasad, C, Singh, S. A New Triterpenoidal from Vernonia cinerea. Planta Med. 1993, 59, 458-60.
27. Kumar, P.P., Kuttan, G. Vernonia cinerea, L. scavenges free radicals and regulates nitric oxide and proinfammatory cytokines profle in carrageenan induced paw edema model. Immunopharmacol. Immunotoxicol. 2009, 31, 94-102.
28. Drabkin, D.L., Austin, J.M. Spectrophotometric studies; spectro-photometric constants for common haemoglobin derivatives in human, dog and rabbit blood. J Biol Chem. 1932, 98, 719-733.
29. Sredni, B., Albeck, M., Kazimirsky, G., Shalit, F. Te immu-nomodulator AS101 administered orally as a chemoprotective and radioprotective agent. Int. J. Immunopharmacol. 1992, 14, 613-9.
30. Bancroft, J.D., Cook, H.F. Manual of Histologic Technique. Churchill Livingstone, London; 1984.
31. Singh, V.K., Agarwal, S.S., Gupta, B.M. Immunomodulatory activ-ity of Panax ginseng extract. Planta Med. 1984, 50, 462-5.
32. Jerne, N.K., Nordin, A.A. Plaque Formation in Agar by Single Antibody-Producing Cells. Science 1963, 140, 405.
33. Mehera, E., Vaidya, M.C. In: Talwar, G.P., Gupta, S.K. (Eds.), Practical and Clinical Immunology. CBS Publishers, New Delhi, 1993. p. 242.
34. Steven, A., Roseberg, D., Longo, L., Lotze, M.T. Principles and Application of Biologic Terapy. In: Devia VT, Hellmann S, Rosenherg SA. (Eds.); 1985.
35. Ohno, S., Tanaka, N., Hizuta, A., Miyagi, K., Orita, K. Lectin-activated killer cells rapidly induced by pokeweed mitogen conjugated beads and their in vivo antitumor efects. Int. J. Immunopharmacol. 1994, 16, 761-8.
36. Boscá, L., Zeini, M., Través, P.G., Hortelano, S. Nitric oxide and cell viability in infammatory cells: a role for NO in macrophage function and fate. Toxicology 2005, 208, 249-58.
37. Lee, S.H., Soyoola, E., Chanmugam, P., Hart, S., Sun, W., Zhong, H., Liou, S., Simmons, D., Hwang. D. J. Biol. Chem. 1992, 2672, 5934-25938.
38. Sonoshita, M., Takaku, K., Oshima, M., Sugihara, K., Taketo, M.M. Cyclooxygenase-2 expression in fbroblasts and endothelial cells of intestinal polyps. Cancer Res. 2002, 62, 6846-9.
39. Shim, V., Gauthier, M.L., Sudilovsky, D., Mantei, K., Chew, K.L., Moore, D.H., Cha, I., Tlsty, T.D., Esserman, L.J. Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. Cancer Res. 2003, 63, 2347-50.
40. Moncada, S., Palmer, R.M., Higgs, E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 1991, 43, 109-42.