Overexpression of Tiam1 predicts poor prognosis in patients with esophageal squamous cell carcinoma

Oncology Reports

Volumn 25, Issue 3, 2011, Pages 841-848

  Liu, Huaimin ^a   Shi, Guirong ^b   Liu, Xiaoli ^c   Wu, Hui ^c   Fan, Qinxia ^a   Wang, Xin ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b Medical College of Shangqiu   (China)

^c Henan Tumor Hospital   (China)

Author keywords

Clinicopathological features; Esophageal squamous cell carcinoma; Prognosis; T cell lymphoma invasion and metastasis 1

Indexed keywords

MESSENGER RNA; PROTEIN; PROTEIN TIAM1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER SURVIVAL; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; ESOPHAGEAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 79551590640     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2010.1122     Document Type: Article

References (32)

1. Kamangar F, Dores GM and Anderson WF: Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 24: 2137-2150, 2006.
2. Parkin DM, Bray FI and Devesa SS: Cancer burden in the year 2000. The global picture. Eur J Cancer 37 (Suppl. 8): S4-S66, 2001.
3. Parkin DM, Laara E and Muir CS: Estimates of the worldwide frequency of sixteen major cancers in 1980. Int J Cancer 41: 184-197, 1988.
4. Yang CS: Research on esophageal cancer in China: a review. Cancer Res 40: 2633-2644, 1980.
5. Layke JC and Lopez PP: Esophageal cancer: a review and update. Am Fam Physician 73: 2187-2194, 2006.
6. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005.
7. Enzinger PC and Mayer RJ: Esophageal cancer. N Engl J Med 349: 2241-2252, 2003.
8. Michiels F, Habets GG, Stam JC, van der Kammen RA and Collard JG: A role for Rac in Tiam1-induced membrane ruffling and invasion. Nature 375: 338-340, 1995.
9. Hordijk PL, ten Klooster JP, van der Kammen RA, Michiels F, Oomen LC and Collard JG: Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science 278: 1464-1466, 1997.
10. Sander EE, van Delft S, ten Klooster JP, Reid T, van der Kammen RA, Michiels F and Collard JG: Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J Cell Biol 143: 1385-1398, 1998.
11. Sander EE, ten Klooster JP, van Delft S, van der Kammen RA and Collard JG: Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J Cell Biol 147: 1009-1022, 1999.
12. Qi Y, Huang B, Yu L, Wang Q, Lan G and Zhang Q: Prognostic value of Tiam1 and Rac1 overexpression in nasopharyngeal carcinoma. ORL J Otorhinolaryngol Relat Spec 71: 163-171, 2009.
13. Minard ME, Kim LS, Price JE and Gallick GE: The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression. Breast Cancer Res Treat 84: 21-32, 2004.
14. Adithi M, Venkatesan N, Kandalam M, Biswas J and Krishnakumar S: Expressions of Rac1, Tiam1 and Cdc42 in retinoblastoma. Exp Eye Res 83: 1446-1452, 2006.
15. Yang W, Lv S, Liu X, Liu H and Hu F: Up-regulation of Tiam1 and Rac1 correlates with poor prognosis in hepatocellular carcinoma. Jpn J Clin Oncol 40: 1053-1059, 2010.
16. Liu HT, Wang N, Wang X and Li SL: Overexpression of Pim-1 is associated with poor prognosis in patients with esophageal squamous cell carcinoma. J Surg Oncol 102: 683-688, 2010.
17. Zhou C, Liu S, Zhou X, Xue L, Quan L, Lu N, Zhang G, Bai J, Wang Y, Liu Z, Zhan Q, Zhu H and Xu N: Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by beta-catenin /TCF pathway in human esophageal squamous cell carcinoma. Int J Cancer 113: 891-898, 2005.
18. Zeng H, Xu L, Xiao D, Zhang H, Wu X, Zheng R, Li Q, Niu Y, Shen Z and Li E: Altered expression of ezrin in esophageal squamous cell carcinoma. J Histochem Cytochem 54: 889-896, 2006.
19. Li S, Xi Y, Zhang H, Wang Y, Wang X, Liu H and Chen K: A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation. Oncol Rep 24: 997-1004, 2010.
20. Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A and Collard JG: Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell 77: 537-549, 1994.
21. Habets GG, van der Kammen RA, Stam JC, Michiels F and Collard JG: Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. Oncogene 10: 1371-1376, 1995.
22. Mertens AE, Roovers RC and Collard JG: Regulation of Tiam1-Rac signalling. FEBS Lett 546: 11-16, 2003.
23. Michiels F and Collard JG: Rho-like GTPases: their role in cell adhesion and invasion. Biochem Soc Symp 65: 125-146, 1999.
24. Engers R, Springer E, Michiels F, Collard JG and Gabbert HE: Rac affects invasion of human renal cell carcinomas by upregulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression. J Biol Chem 276: 41889-41897, 2001.
25. Uhlenbrock K, Eberth A, Herbrand U, Daryab N, Stege P, Meier F, Friedl P, Collard JG and Ahmadian MR: The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. J Cell Sci 117: 4863-4871, 2004.
26. Malliri A, Rygiel TP, van der Kammen RA, Song JY, Engers R, Hurlstone AF, Clevers H and Collard JG: The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem 281: 543-548, 2006.
27. Engers R, Mueller M, Walter A, Collard JG, Willers R and Gabbert HE: Prognostic relevance of Tiam1 protein expression in prostate carcinomas. Br J Cancer 95: 1081-1086, 2006.
28. Adam L, Vadlamudi RK, McCrea P and Kumar R: Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta-catenin nuclear signaling in breast cancer cells by modulating the intercellular stability. J Biol Chem 276: 28443-28450, 2001.
29. Wang DY, Xiang YY, Tanaka M, Li XR, Li JL, Shen Q, Sugimura H and Kino I: High prevalence of p53 protein overexpression in patients with esophageal cancer in Linxian, China and its relationship to progression and prognosis. Cancer 74: 3089-3096, 1994.
30. Ikeda G, Isaji S, Chandra B, Watanabe M and Kawarada Y: Prognostic significance of biologic factors in squamous cell carcinoma of the esophagus. Cancer 86: 1396-1405, 1999.
31. Yoshida K, Kawami H, Yamaguchi Y, Kuniyasu H, Nishiyama M, Hirai T, Yanagihara K, Tahara E and Toge T: Retrovirally transmitted gene therapy for gastric carcinoma using herpes simplex virus thymidine kinase gene. Cancer 75: 1467-1471, 1995.
32. Walch A, Seidl S, Hermannstadter C, Rauser S, Deplazes J, Langer R, von Weyhern CH, Sarbia M, Busch R, Feith M, Gillen S, Hofler H and Luber B: Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer. Mod Pathol 21: 544-552, 2008.