Assessing the temperature of thermally generated inhalation aerosols

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 24, Issue 1, 2011, Pages 11-15

  Noymer, Peter D ^a   Myers, Dan J ^a   Cassella, James V ^a   Timmons, Ryan ^b  

^a Alexza Pharmaceuticals   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

condensation; energy; Staccato; thermal aerosol; wet bulb temperature

Indexed keywords

AEROSOL; AIRFLOW; AMBIENT AIR; ARTICLE; INHALATION; TEMPERATURE; THERMAL ANALYSIS; THERMAL VAPORIZATION; VAPORIZATION;

ADMINISTRATION, INHALATION; AEROSOLS; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HUMANS; HUMIDITY; NEBULIZERS AND VAPORIZERS; PHARMACEUTICAL PREPARATIONS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 79551577252     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2010.0835     Document Type: Article

References (11)

1. Rabinowitz JD, Wensley M, Lloyd P, Myers D, Shen W, Lu A, Hodges C, Hale R, Mufson D, and Zaffaroni A: Fast onset medications through thermally generated aerosols. J Pharmacol Exp Ther. 2004;309:769-775.
2. Rabinowitz JD, Lloyd PM, Munzar P, Myers DJ, Cross S, Damani R, Quintana R, Spyker DA, Soni P, and Cassella JV: Ultra-fast absorption of amorphous pure drug aerosols via deep lung inhalation. J Pharm Sci. 2006;95:2438-2451.
3. Myers DJ, Timmons RD, Lu AT, Hale RL, Solas DW, Soni P, and Rabinowitz JD: The effect of film thickness on thermal aerosol generation. Pharm Res. 2007;24:336-342.
4. Cox KA, Nguyen TT, McRae DD, Demian BA, and Gregory SM: Condensation aerosols: a new option for targeted delivery of drugs to the pulmonary region. Respir Drug Deliv 2002; VIII:231-238.
5. Cox, KA, Beane TP, and Sweeney WR: Aerosol generator and methods of making and using an aerosol generator. US patent number 6,234,167. 2001.
6. Killick EM: Physiological response to breathing hot air. J Hyg (Lond) 1932;32:332-339.
7. Takahashi M, Mano Y, Shibayama M, and Yamami N: Acceptability of elevated breathing gas temperature and humidity in relation to ventilation rate. JISRP 1999;17:13-20.
8. American Society for Heating, Refrigeration and Air- Conditioning: ASHRAE Handbook-Fundamentals, Chap. 6. ASHRAE, Atlanta, GA; 2005.
9. McFadden ER, Pichurko BM, Bowman HF, Ingenito E, Burns S, Dowling N, and Solway J: Thermal mapping of the airways in humans. J Appl Physiol. 1985;58:564-570.
10. Kyriazi N: Proposal for certification tests and standards for closed-circuit breathing apparatus. NIOSH 1999; Information Circular #9449.
11. European Committee for Standardization (CEN): Respiratory protective devices for self-rescue-filter self-rescuer from carbon monoxide with mouthpiece assembly; EN404 2005; Section 6.18.3.