Nuclear transfer to prevent mitochondrial DNA disorders: Revisiting the debate on reproductive cloning

Reproductive BioMedicine Online

Volumn 22, Issue 2, 2011, Pages 200-207

  Bredenoord, A L ^a   Dondorp, W ^a   Pennings, G ^a   De Wert, G ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

ethics; mitochondrial DNA disorders; nuclear transfer; reproductive cloning

Indexed keywords

ARTICLE; BLASTOMERE; CELL NUCLEUS TRANSPLANTATION; CLONING; EMBRYO TRANSFER; GERMINAL VESICLE; HUMAN; MITOCHONDRIAL DNA DISORDER; SPINDLE CELL;

BLASTOMERES; CLONING, ORGANISM; HUMANS; MITOCHONDRIAL DISEASES; NUCLEAR TRANSFER TECHNIQUES;

EID: 79551567068     PISSN: 14726483     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rbmo.2010.10.016     Document Type: Article

References (56)

1. J.D. Arras AIDS and reproductive decisions: having children in fear and trembling Milbank Q. 68 1990 353 382
2. D. Beyleveld, and R. Brownsword Human Dignity in Bioethics and Biolaw 2001 Oxford University Press Oxford
3. Braude, P., 2007. One Child at a Time. Reducing Multiple Births After IVF. Report of the Expert Group on Multiple Birth after IVF. Available from: < http://www.hfea.gov.uk/docs/MBSET-report-Final-Dec-06.pdf >.
4. A.L. Bredenoord, G. Pennings, and G. de Wert Ooplasmic transfer and nuclear transfer to prevent mitochondrial DNA disorders: conceptual and normative issues Hum. Reprod. Update 14 2008 669 678
5. A.L. Bredenoord, W. Dondorp, G. Pennings, C.E.M. de Die-Smulders, and G. de Wert PGD to reduce reproductive risk: the case of mitochondrial DNA disorders Hum. Reprod. 23 2008 2392 2401
6. British Medical Association, 1999. Human 'Cloning': A Discussion Paper for the World Medical Association. Available from: < http://www.bma.org.uk/ ap.nsf/Content/Humancloning >.
7. D.W. Brock Human cloning and our sense of self Science 296 2002 314 316
8. D.W. Brock Cloning human beings: an assessment of the ethical issues pro and con M.C. Nussbaum, C.R. Sunstein, Clones and Clones. Facts and Fantasies about Human Cloning 1998 WW Norton and Company New York/London 141 164
9. D.T. Brown, M. Herbert, and V.K. Lamb Transmission of mitochondrial DNA disorders: possibilities for the future Lancet 368 2006 87 89
10. A. Buchanan, D.W. Brock, N. Daniels, and D. Wikler From Chance to Choice 2000 Cambridge University Press Genetics and Justice, Cambridge
11. T. Caulfield, and R. Brownsword Human dignity: a guide to policy making in the biotechnology era? Nat. Rev. Genet. 7 2006 72 76
12. Council of Europe, 1998. Additional protocol to the Convention for the Protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine, on the Prohibition of Cloning Human Beings. ETS no. 168.
13. R. Cole-Turner Human limits. Theological perspectives on germ-line modification A.R. Chapman, M.S. Frankel, Designing our Descendants. The Promise and Perils of Genetic Modification 2003 The Johns Hopkins University Press Baltimore and London 188 198
14. Craven, L., Tuppen, H.A., Greggains, G.D., et al., 2010. Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature, advance online publication 14 April 2010. doi: 10.1038/nature08958.
15. de Wert, G., 2000. Human cloning: the case of the (preimplantation) embryo, and ethical exploration. In: Gunning, J. (Ed.), Assisted Conception. Research, ethics and law, Aldershot, etc: Ashgate Darthmouth. pp. 83-107.
16. G. de Wert The post-menopause: playground for reproductive technology? Some ethical reflections J. Harris, S. Holm, The Future of Human Reproduction. Ethics, Choice and Regulation 1998 Clarendon Press Oxford 221 237
17. B.C.J.M. Fauser, P. Devroey, and N.S. Macklon Multiple birth resulting from ovarian stimulation for subfertility treatment Lancet 365 2005 1807 1816
18. J. Feinberg The child's right to an open future W. Aiken, H. LaFolette, Whose Child? Children's Rights, Parental Authority, and State Power 1980 Rowman and Littlefield Totowa, NJ
19. C.R. Ferreira, F.V. Meirelles, and W. Yamazaki The kinetics of donor cell mtDNA in embryonic and somatic donor cell-derived bovine embryos Cloning Stem Cells 9 2007 618 629
20. F. Fukuyama Our Posthuman Future. Consequences of the Biotechnology Revolution 2002 Picador New York
21. J. Fulka Jr., M. Mrazek, H. Fulka, and P. Loi Mammalian oocyte therapies Cloning Stem Cells 7 2005 183 188
22. J.L. Gardner, L. Craven, D.M. Turnbull, and R.W. Taylor Experimental strategies towards treating mitochondrial DNA Disorders Biosci. Rep. 27 2007 139 150
23. R. Gillon Human reproductive cloning - a look at the arguments against it and a rejection of most of them J. Roy. Soc. Med. 92 1999 3 12
24. J. Glover Choosing Children. Genes, Disability, and Design 2006 Clarendon Press Oxford
25. J. Harris 'Goodbye Dolly?' The ethics of human cloning J. Med. Ethics 23 1997 353 360
26. S. Hiendleder, S.M. Schmutz, G. Erhardt, R.D. Green, and Y. Plante Transmitochondrial differences and varying levels of heteroplasmy in nuclear transfer cloned cattle Mol. Reprod. Dev. 54 1999 24 31
27. S. Holm A life in shadows: one reason why we should not clone humans Camb. Q. Healthc. Ethics 7 1998 160 162
28. Human Fertilization and Embryology Authority RO153. Available from: < http://www.hfea.gov.uk/docs/R0153-How-the-decision-was-made-to-license-this- research-project-2-pfd >.
29. J.P. Jenuth, A.C. Peterson, K. Fu, and E.A. Shoubridge Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA Nat. Genet. 14 1996 146 151
30. H. Jonas Philosophical Essays: from Ancient Creed to Technological Man 1974 Prentice Hall New York
31. L.R. Kass Defending human dignity President's Council on Bioethics, Human Dignity and Bioethics 2008 The President's Council on Bioethics Washington, DC 297 331
32. L.R. Kass Life, Liberty, and the Defense of Dignity. The Challenge for Bioethics 2002 Encounter Books San Francisco
33. F.V. Meirelles, and L.C. Smith Mitochondrial genotype segregation in a mouse heteroplasmic lineage produced by embryonic karyoplast transplantation Genetics 145 1997 445 451
34. F.V. Meirelles, and L.C. Smith Mitochondrial genotype segregation during preimplantation development in mouse heteroplasmic embryos Genetics 148 1998 877 883
35. S.M. Mitalipov, R.R. Yeoman, K.D. Nusser, and D.P. Wolf Rhesus monkey embryos produced by nuclear transfer from embryonic blastomeres or somatic cells Biol. Reprod. 66 2002 1367 1373
36. M.C. Nussbaum Hiding from Humanity. Disgust, Shame, and the Law 2004 Princeton University Press Princeton
37. D. Parfit Reasons and Persons 1984 Oxford University Press Oxford
38. M. Parker The welfare of the child Hum. Fertil. 8 2005 13 17
39. G. Pennings Measuring the welfare of the child: in search of the appropriate evaluation principle Hum. Reprod. 14 1999 1146 1150
40. Poulton, J., Bredenoord, A.L., 2010. 174th ENMC International Workshop: Applying Pre-implantation Genetic Diagnosis to mtDNA Diseases: Implications of Scientific Advances. 19-21 March 2010, Naarden, The Netherlands. Neuromuscular Disorders 20, pp. 559-563.
41. J. Poulton, M.R. Chiaratti, F.V. Meirelles, S. Kennedy, D. Wells, and I.J. Holt Transmission of mitochondrial DNA diseases and ways to prevent them PLoS Genet. 6 2010 8 pii: e1001066
42. President's Council on Bioethics Human Dignity and Bioethics 2008 The President's Council on Bioethics Washington, DC
43. President's Council on Bioethics Human Cloning and Human Dignity. An Ethical Inquiry 2002 The President's Council on Bioethics Washington, DC
44. R.M. Roberts Prevention of human mitochondrial (mtDNA) disease by nucleus transplantation into an enucleated donor oocyte Am. J. Med. Genet. 87 1999 265 266
45. M.J. Sandel The Case against Perfection. Ethics in the Age of Genetic Engineering 2007 The Belknap Press of Harvard University Press Cambridge and London
46. A. Sato, T. Kono, and K. Nakada Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation Proc. Natl. Acad. Sci. USA 102 2005 16765 16770
47. E.C. Spikings, J. Alderson, and J.C.St. John Transmission of mitochondrial DNA following assisted reproduction and nuclear transfer Hum. Reprod. Update 12 2006 401 415
48. B. Steinbock, and R. McClamrock When is birth unfair to the child? Hastings Cent. Rep. 6 1994 15 21
49. Steinborn, R., Schinogl, P., Zakhartchenko, V., et al., 2000. Mitochondrial DNA heteroplasmy in cloned cattle produced by fetal and adult cell cloning. Nat. Genet. 25, 255-257.
50. R. Steinborn, V. Zakhartchenko, E. Wolf, M. Müller, and G. Brem Non-balanced mix of mitochondrial DNA in cloned cattle produced by cytoplast-blastomere fusion FEBS Lett. 426 1998 357 361
51. M. Tachibana, M. Sparman, and H. Sritanaudomchai Mitochondrial gene replacement in primate offspring and embryonic stem cells Nature 461 2009 367 372
52. R.W. Taylor, and D.M. Turnbull Mitochondrial DNA mutations in human disease Nat. Rev. Genet. 6 2005 389 402
53. United Nations, 2005. United Nations Declaration on Human Cloning. A/RES/59/280. Available from: < http://daccessdds.un.org/doc/UNDOC/GEN/N04/ 493/06/PDF/N0449306.pdf?OpenElement >.
54. United Nations, 1997. United Nations Universal Declaration on the Human Genome and Human Rights. Available from: < http://unesdoc.unesco.org/images/ 0011/001102/110220e.pdf page=47 >.
55. R. van der Graaf, and J.J.M. van Delden Clarifying appeals to dignity in medical ethics from an historical perspective Bioethics 23 2009 151 160
56. J. Zhang, G.L. Zhuang, Y. Zeng, C. Acosta, Y.M. Shu, and J. Grifo Pregnancy derived from human nuclear transfer Fertil. Steril. 80 2003 S56