메뉴 건너뛰기




Volumn 121, Issue 2, 2011, Pages 508-509

The cautionary tale of side effects of chronic Notch1 inhibition

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; DELTA LIKE 4 ANTIBODY; GAMMA SECRETASE INHIBITOR; NOTCH1 ANTIBODY; NOTCH1 RECEPTOR; NOTCH2 ANTIBODY; NOTCH2 RECEPTOR; UNCLASSIFIED DRUG;

EID: 79551553121     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI45976     Document Type: Note
Times cited : (39)

References (12)
  • 2
    • 77953158971 scopus 로고    scopus 로고
    • Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma
    • Hanlon L, et al. Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. Cancer Res. 2010;70(11):4280- 4286.
    • (2010) Cancer Res , vol.70 , Issue.11 , pp. 4280-4286
    • Hanlon, L.1
  • 3
    • 78650082224 scopus 로고    scopus 로고
    • Prognostic impact of Notch ligands and receptors in non-small cell lung cancer: Co-expression of Notch-1 and vascular endothelial growth factor-A predicts poor survival
    • Donnem T, Andersen S, Al-Shibli K, Al-Saad S, Busund LT, Bremnes RM. Prognostic impact of Notch ligands and receptors in non-small cell lung cancer: co-expression of Notch-1 and vascular endothelial growth factor-A predicts poor survival. Cancer. 2010;116(24):5676-5685.
    • (2010) Cancer , vol.116 , Issue.24 , pp. 5676-5685
    • Donnem, T.1    Andersen, S.2    Al-Shibli, K.3    Al-Saad, S.4    Busund, L.T.5    Bremnes, R.M.6
  • 4
    • 77954215506 scopus 로고    scopus 로고
    • Notch signaling: Emerging molecular targets for cancer therapy
    • Yin L, Velazquez OC, Liu ZJ. Notch signaling: emerging molecular targets for cancer therapy. Biochem Pharmacol. 2010;80(5):690-701.
    • (2010) Biochem Pharmacol , vol.80 , Issue.5 , pp. 690-701
    • Yin, L.1    Velazquez, O.C.2    Liu, Z.J.3
  • 5
    • 33845907380 scopus 로고    scopus 로고
    • Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
    • Ridgway J, et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature. 2006;444(7122):1083-1087.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1083-1087
    • Ridgway, J.1
  • 6
    • 33947214529 scopus 로고    scopus 로고
    • Notch signaling, gamma-secretase inhibitors, and cancer therapy
    • DOI 10.1158/0008-5472.CAN-06-3958
    • Shih IeM, Wang TL. Notch signaling, gamma-secretase inhibitors, and cancer therapy. Cancer Res. 2007;67(5):1879-1882. (Pubitemid 46424200)
    • (2007) Cancer Research , vol.67 , Issue.5 , pp. 1879-1882
    • Shih, I.-M.1    Wang, T.-L.2
  • 7
    • 0142259346 scopus 로고    scopus 로고
    • The role of Notch in tumorigenesis: Oncogene or tumour suppressor?
    • Radtke F, Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer. 2003;3(10):756-767.
    • (2003) Nat Rev Cancer , vol.3 , Issue.10 , pp. 756-767
    • Radtke, F.1    Raj, K.2
  • 8
    • 20544460148 scopus 로고    scopus 로고
    • Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
    • van Es JH, et al. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature. 2005;435(7044):959-963.
    • (2005) Nature , vol.435 , Issue.7044 , pp. 959-963
    • Van Es, J.H.1
  • 9
    • 77951139188 scopus 로고    scopus 로고
    • Therapeutic antibody targeting of individual Notch receptors
    • Wu Y, et al. Therapeutic antibody targeting of individual Notch receptors. Nature. 2010;464(7291):1052-1057.
    • (2010) Nature , vol.464 , Issue.7291 , pp. 1052-1057
    • Wu, Y.1
  • 10
    • 1542317449 scopus 로고    scopus 로고
    • Notch regulation of lymphocyte development and function
    • Radtke F, Wilson A, Mancini SJ, MacDonald HR. Notch regulation of lymphocyte development and function. Nat Immunol. 2004;5(3):247-253.
    • (2004) Nat Immunol , vol.5 , Issue.3 , pp. 247-253
    • Radtke, F.1    Wilson, A.2    Mancini, S.J.3    MacDonald, H.R.4
  • 11
    • 76749157186 scopus 로고    scopus 로고
    • Chronic DLL4 blockade induces vascular neoplasms
    • Yan M, et al. Chronic DLL4 blockade induces vascular neoplasms. Nature. 2010;463(7282):E6-E7.
    • (2010) Nature , vol.463 , Issue.7282
    • Yan, M.1
  • 12
    • 79551510137 scopus 로고    scopus 로고
    • Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice
    • Liu Z, et al. Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest. 2011;121(2):800-808.
    • (2011) J Clin Invest , vol.121 , Issue.2 , pp. 800-808
    • Liu, Z.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.