Injury-induced activation of ERK 1/2 in the sciatic nerve of healthy and diabetic rats

NeuroReport

Volumn 22, Issue 2, 2011, Pages 73-77

  Stenberg, Lena ^a   Kanje, Martin ^b   Mårtensson, Lisa ^b   Dahlin, Lars B ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

BioBreeding rats; Diabetes; Nerve injury; Nerve transaction; Neuropathy; Phosphorylation of extracellular signal regulated kinase 1 2; Streptozotocin

Indexed keywords

GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIABETIC NEUROPATHY; DISEASE ASSOCIATION; ENZYME ACTIVATION; FEMALE; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; NERVE STUMP; NERVE TRANSECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SCHWANN CELL; SCIATIC NERVE; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES;

ANIMALS; AXONS; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; RATS; RATS, WISTAR; SCHWANN CELLS; SCIATIC NERVE; TIME FACTORS;

EID: 79551527646     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328342986c     Document Type: Article

References (20)

1. Purves T, Middlemas A, Agthong S, Jude EB, Boulton AJ, Fernyhough P, Tomlinson DR. A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy. FASEB J 2001; 15:2508-2514.
2. Agthong S, Kaewsema A, Tanomsridejchai N, Chentanez V. Activation of MAPK ERK in peripheral nerve after injury. BMC Neurosci 2006; 7:45.
3. Sheu JY, Kulhanek DJ, Eckenstein FP. Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat. Exp Neurol 2000; 166:392-402.
4. Martensson L, Gustavsson P, Dahlin LB, Kanje M. Activation of extracellularsignal- regulated kinase-1/2 precedes and is required for injury-induced Schwann cell proliferation. Neuroreport 2007; 18:957-961.
5. Reynolds AJ, Hendry IA, Bartlett SE. Anterograde and retrograde transport of active extracellular signal-related kinase 1 (ERK 1) in the ligated rat sciatic nerve. Neuroscience 2001; 105:761-771.
6. Zhong Z, Davidescu A, Ehren I, Ekberg K, Jornvall H,Wahren J, Chibalin AV. C-peptide stimulates ERK 1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells. Diabetologia 2005; 48:187-197.
7. Middlemas A, Delcroix JD, Sayers NM, Tomlinson DR, Fernyhough P. Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3. Brain 2003; 126:1671-1682.
8. Cai F, Tomlinson DR, Fernyhough P. Elevated expression of neurotrophin-3 mRNA in sensory nerve of streptozotocin-diabetic rats. Neurosci Lett 1999; 263:81-84. (Pubitemid 29158933)
9. Price SA, Hounsom L, Purves-Tyson TD, Fernyhough P, Tomlinson DR. Activation of JNK in sensory neurons protects against sensory neuron cell death in diabetes and on exposure to glucose/oxidative stress in vitro. Ann N Y Acad Sci 2003; 1010:95-99.
10. Averill S, Delcroix JD, Michael GJ, Tomlinson DR, Fernyhough P, Priestley JV. Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones. Mol Cell Neurosci 2001; 18:183-196.
11. Lundborg G, Rydevik B. Effects of stretching the tibial nerve of the rabbit. A preliminary study of the intraneural circulation and the barrier function of the perineurium. J Bone Joint Surg 1973; 55B:390-401.
12. Sidenius P. The axonopathy of diabetic neuropathy. Diabetes 1982; 31:356-363.
13. Dahlin LB, Stenberg L, Luthman H, Thomsen NO. Nerve compression induces activating transcription factor 3 in neurons and Schwann cells in diabetic rats. Neuroreport 2008; 19:987-990.
14. Jessen KR, Mirsky R. Negative regulation of myelination: relevance for development, injury, and demyelinating disease. Glia 2008; 56:1552-1565.
15. Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW, Lloyd AC. The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation. EMBO J 2004; 23:3061-3071.
16. Ogata T, Iijima S, Hoshikawa S, Miura T, Yamamoto S, Oda H, et al. Opposing extracellular signal-regulated kinase and Akt pathways control Schwann cell myelination. J Neurosci 2004; 24:6724-6732.
17. Fischer S,Weishaupt A, Troppmair J, Martini R. Increase of MCP-1 (CCL2) in myelin mutant Schwann cells is mediated by MEK-ERK signaling pathway. Glia 2008; 56:836-843.
18. Terada M, Yasuda H, Kikkawa R. Delayed Wallerian degeneration and increased neurofilament phosphorylation in sciatic nerves of rats with streptozocin-induced diabetes. J Neurol Sci 1998; 155:23-30.
19. Kogawa S, Yasuda H, Terada M, Maeda K, Kikkawa R. Apoptosis and impaired axonal regeneration of sensory neurons after nerve crush in diabetic rats. Neuroreport 2000; 11:663-667.
20. Yasuda H, Terada M, Maeda K, Kogawa S, Sanada M, Haneda M, et al. Diabetic neuropathy and nerve regeneration. Prog Neurobiol 2003; 69:229-285.