Phase i study of preoperative chemoradiation with S-1 and oxaliplatin in patients with locally advanced resectable rectal cancer

International Journal of Radiation Oncology Biology Physics

Volumn 79, Issue 3, 2011, Pages 684-689

  Hong, Yong Sang ^a   Lee, Jae Lyun ^a   Park, Jin Hong ^a   Kim, Jong Hoon ^a   Yoon, Sang Nam ^a   Lim, Seok Byung ^a   Yu, Chang Sik ^a   Kim, Mi Jung ^a   Jang, Se Jin ^a   Lee, Jung Shin ^a   Kim, Jin Cheon ^a   Kim, Tae Won ^a  

^a University of Ulsan   (South Korea)

Author keywords

Oxaliplatin; Phase I study; Preoperative chemoradiotherapy; Rectal cancer; S 1

Indexed keywords

CHEMORADIOTHERAPY; OXALIPLATIN; PHASE I; RECTAL CANCER; S-1;

CHEMOTHERAPY; DISEASES;

TOXICITY;

5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; OXALIPLATIN;

ADULT; ADVANCED CANCER; AGED; ALOPECIA; ANEMIA; ANOREXIA; ARTICLE; CANCER SURGERY; CHEMORADIOTHERAPY; CHEMOTHERAPY INDUCED EMESIS; CLINICAL ARTICLE; CONSTIPATION; DIARRHEA; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; HAND FOOT SYNDROME; HUMAN; HUMAN TISSUE; HYPERBILIRUBINEMIA; LEUKOPENIA; MALE; MAXIMUM TOLERATED DOSE; NAUSEA; NEUTROPENIA; PHASE 1 CLINICAL TRIAL; PREOPERATIVE CARE; PRIORITY JOURNAL; RADIATION DOSE; RECOMMENDED DRUG DOSE; RECTUM CANCER; SENSORY NEUROPATHY; SIDE EFFECT; STOMATITIS; THROMBOCYTOPENIA; TREATMENT RESPONSE;

ADENOCARCINOMA; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; DIARRHEA; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; HUMANS; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; NAUSEA; NEUTROPENIA; ORGANOPLATINUM COMPOUNDS; OXONIC ACID; PREOPERATIVE CARE; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS; TEGAFUR; THROMBOCYTOPENIA; VOMITING;

EID: 79551502363     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.11.037     Document Type: Article

References (33)

1. R. Sauer, H. Becker, and W. Hohenberger Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 351 2004 1731 1740
2. J.P. Gerard, T. Conroy, and F. Bonnetain Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203 J Clin Oncol 24 2006 4620 4625
3. J.F. Bosset, L. Collette, and G. Calais Chemotherapy with preoperative radiotherapy in rectal cancer N Engl J Med 355 2006 1114 1123
4. J.P. Gerard, O. Chapet, and C. Nemoz Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: The Lyon R0-04 phase II trial J Clin Oncol 21 2003 1119 1124
5. J. Giralt, J. Tabernero, and B. Navalpotro Pre-operative chemoradiotherapy with UFT and leucovorin in patients with advanced rectal cancer: A phase II study Radiother Oncol 89 2008 263 269
6. J.C. Kim, T.W. Kim, and J.H. Kim Preoperative concurrent radiotherapy with capecitabine before total mesorectal excision in locally advanced rectal cancer Int J Radiat Oncol Biol Phys 63 2005 346 353
7. Y. Kundel, B. Brenner, and Z. Symon A phase II study of oral UFT and leucovorin concurrently with pelvic irradiation as neoadjuvant chemoradiation for rectal cancer Anticancer Res 27 2007 2877 2880
8. D.Y. Kim, K.H. Jung, and T.H. Kim Comparison of 5-fluorouracil/leucovorin and capecitabine in preoperative chemoradiotherapy for locally advanced rectal cancer Int J Radiat Oncol Biol Phys 67 2007 378 384
9. R. Hofheinz, F. Wenz, and S. Post Capecitabine (Cape) versus 5-fluorouracil (5-FU)-based (neo-)adjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC): Safety results of a randomized, phase III trial (Abstr.) J Clin Oncol 27 2009 171S
10. H.C. Jeung, S.Y. Rha, and B.C. Cho A phase II trial of S-1 monotherapy in metastatic colorectal cancer after failure of irinotecan- and oxaliplatin-containing regimens Br J Cancer 95 2006 1637 1641
11. S.Y. Kim, Y.S. Hong, and B.C. Kim A phase II study of S-1 plus irinotecan and oxaliplatin in heavily-treated patients with metastatic colorectal cancer Invest New Drugs 27 2009 269 274
12. J.L. Lee, Y.K. Kang, and H.J. Kang A randomised multicentre phase II trial of capecitabine vs S-1 as first-line treatment in elderly patients with metastatic or recurrent unresectable gastric cancer Br J Cancer 99 2008 584 590
13. D.Y. Zang, B.H. Lee, and H.C. Park Phase II study with oxaliplatin and S-1 for patients with metastatic colorectal cancer Ann Oncol 20 2009 892 896
14. E. Nakata, M. Fukushima, and Y. Takai S-1, an oral fluoropyrimidine, enhances radiation response of DLD-1/FU human colon cancer xenografts resistant to 5-FU Oncol Rep 16 2006 465 471
15. T. Sato, Y. Kokuba, and W. Koizumi Phase I trial of neoadjuvant preoperative chemotherapy with S-1 and irinotecan plus radiation in patients with locally advanced rectal cancer Int J Radiat Oncol Biol Phys 69 2007 1442 1447
16. H.J. Choi, N.K. Kim, and K.C. Keum Phase I trial of neoadjuvant concurrent chemoradiotherapy with S-1 and weekly irinotecan in locally advanced rectal cancer Radiother Oncol 87 2008 361 366
17. H.M. Kim, S. Bang, and J.Y. Park Phase II trial of S-1 and concurrent radiotherapy in patients with locally advanced pancreatic cancer Cancer Chemother Pharmacol 63 2009 535 541
18. F. Ohyanagi, N. Yamamoto, and A. Horiike Phase II trial of S-1 and cisplatin with concurrent radiotherapy for locally advanced non-small-cell lung cancer Br J Cancer 101 2009 225 231
19. T. Nakao Micro RNA expression to predict side effects of preoperative chemoradiotherapy in rectal cancer (Abstr.) J Clin Oncol 27 2009 e22211
20. F. Willeke, K. Horisberger, and U. Kraus-Tiefenbacher A phase II study of capecitabine and irinotecan in combination with concurrent pelvic radiotherapy (CapIri-RT) as neoadjuvant treatment of locally advanced rectal cancer Br J Cancer 96 2007 912 917
21. R.D. Hofheinz, B. von Gerstenberg-Helldorf, and F. Wenz Phase I trial of capecitabine and weekly irinotecan in combination with radiotherapy for neoadjuvant therapy of rectal cancer J Clin Oncol 23 2005 1350 1357
22. G. Klautke, U. Kuchenmeister, and T. Foitzik Concurrent chemoradiation with capecitabine and weekly irinotecan as preoperative treatment for rectal cancer: Results from a phase I/II study Br J Cancer 94 2006 976 981
23. J.J. Aristu, L. Arbea, and J. Rodriguez Phase I-II trial of concurrent capecitabine and oxaliplatin with preoperative intensity-modulated radiotherapy in patients with locally advanced rectal cancer Int J Radiat Oncol Biol Phys 71 2008 748 755
24. M.G. Fakih, K. Bullarddunn, and G.Y. Yang Phase II study of weekly intravenous oxaliplatin combined with oral daily capecitabine and radiotherapy with biologic correlates in neoadjuvant treatment of rectal adenocarcinoma Int J Radiat Oncol Biol Phys 72 2008 650 657
25. J.P. Machiels, L. Duck, and B. Honhon Phase II study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: The RadiOxCape study Ann Oncol 16 2005 1898 1905
26. C. Rodel, T. Liersch, and R.M. Hermann Multicenter phase II trial of chemoradiation with oxaliplatin for rectal cancer J Clin Oncol 25 2007 110 117
27. A. de Gramont, A. Figer, and M. Seymour Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer J Clin Oncol 18 2000 2938 2947
28. O. Dworak, L. Keilholz, and A. Hoffmann Pathological features of rectal cancer after preoperative radiochemotherapy Int J Colorectal Dis 12 1997 19 23
29. J.Y. Douillard, D. Cunningham, and A.D. Roth Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial Lancet 355 2000 1041 1047
30. R. Glynne-Jones, J. Dunst, and D. Sebag-Montefiore The integration of oral capecitabine into chemoradiation regimens for locally advanced rectal cancer: how successful have we been? Ann Oncol 17 2006 361 371
31. J. Gerard, D. Azria, and S. Gourgou-Bourgade Randomized multicenter phase III trial comparing two neoadjuvant chemoradiotherapy (CT-RT) regimens (RT45-Cap versus RT50-Capox) in patients (pts) with locally advanced rectal cancer (LARC): Results of the ACCORD 12/0405 PRODIGE 2 (Abstr.) J Clin Oncol 27 2009 169S
32. T. Andre, C. Boni, and M. Navarro Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC Trial J Clin Oncol 27 2009 3109 3116
33. B. Nordlinger, H. Sorbye, and B. Glimelius Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): A randomised controlled trial Lancet 371 2008 1007 1016