Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: A pilot study

Psychoneuroendocrinology

Volumn 36, Issue 2, 2011, Pages 289-293

  Coplan, Jeremy D ^a,b,c   Abdallah, Chadi G ^a   Kaufman, Joan ^d,e   Gelernter, Joel ^d   Smith, Eric L P ^a   Perera, Tarique D ^b,c   Dwork, Andrew J ^b,c   Kaffman, Arie ^d   Gorman, Jack M ^f   Rosenblum, Leonard A ^a   Owens, Michael J ^g   Nemeroff, Charles B ^h  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c College of Physicians and Surgeons of Columbia University ^*  (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f Univ S Carolina Sch Med Vice P   (United States)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Anxiety disorders; Corticotropin releasing hormone; Early life stress; Gene by environment interaction; Major depression; Nonhuman primates; Serotonin transporter gene

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; SEROTONIN TRANSPORTER;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DEPRESSION; EARLY LIFE STRESS; FORAGING BEHAVIOR; GENE INTERACTION; GENETIC POLYMORPHISM; GENOTYPE; MACACA RADIATA; MALE; NONHUMAN; PATHOGENESIS; PILOT STUDY; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; CORTICOTROPIN-RELEASING HORMONE; FEMALE; GENOTYPE; HOUSING, ANIMAL; MACACA RADIATA; MALE; MATERNAL BEHAVIOR; NESTING BEHAVIOR; PILOT PROJECTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL;

EID: 79551496851     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2010.07.011     Document Type: Article

References (15)

1. Barr C.S., Newman T.K., Shannon C., Parker C., Dvoskin R.L., Becker M.L., Schwandt M., Champoux M., Lesch K.P., Goldman D., Suomi S.J., Higley J.D. Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biol. Psychiatry 2004, 55:733-738.
2. Bennett A.J., Lesch K.P., Heils A., Long J.C., Lorenz J.G., Shoaf S.E., Champoux M., Suomi S.J., Linnoila M.V., Higley J.D. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol. Psychiatry 2002, 7:118-122.
3. Carpenter L.L., Tyrka A.R., McDougle C.J., Malison R.T., Owens M.J., Nemeroff C.B., Price L.H. Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects. Neuropsychopharmacology 2004, 29:777-784.
4. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., McClay J., Mill J., Martin J., Braithwaite A., Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003, 301:386-389.
5. Coplan J.D., Altemus M., Mathew S.J., Smith E.L., Sharf B., Coplan P.M., Kral J.G., Gorman J.M., Owen M.J., Nemeroff C.B., Rosenblum L.A. Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand. CNS Spectr. 2005, 10:530-536.
6. Kaufman J., Yang B.Z., Douglas-Palumberi H., Houshyar S., Lipschitz D., Krystal J.H., Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:17316-17321.
7. Lee R., Geracioti T.D., Kasckow J.W., Coccaro E.F. Childhood trauma and personality disorder: positive correlation with adult CSF corticotropin-releasing factor concentrations. Am. J. Psychiatry 2005, 162:995-997.
8. Lesch K.P., Gross J., Franzek E., Wolozin B.L., Riederer P., Murphy D.L. Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biol. Psychiatry 1995, 37:215-223.
9. Nemeroff C.B., Widerlov E., Bissette G., Walleus H., Karlsson I., Eklund K., Kilts C.D., Loosen P.T., Vale W. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 1984, 226:1342-1344.
10. Ressler K.J., Bradley B., Mercer K.B., Deveau T.C., Smith A.K., Gillespie C.F., Nemeroff C.B., Cubells J.F., Binder E.B. Polymorphisms in CRHR1 and the serotonin transporter loci: gene×gene×environment interactions on depressive symptoms. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2010, 153B:812-824.
11. Risch N., Herrell R., Lehner T., Liang K.Y., Eaves L., Hoh J., Griem A., Kovacs M., Ott J., Merikangas K.R. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA 2009, 301:2462-2471.
12. Rosenblum L.A., Paully G.S. The effects of varying environmental demands on maternal and infant behavior. Child Dev. 1984, 55:305-314.
13. Rutter M., Thapar A., Pickles A. Gene-environment interactions: biologically valid pathway or artifact?. Arch. Gen. Psychiatry 2009, 66:1287-1289.
14. Tyrka A.R., Carpenter L.L., McDougle C.J., Kirwin P.D., Owens M.J., Nemeroff C.B., Strong D.R., Price L.H. Increased cerebrospinal fluid corticotropin-releasing factor concentrations during tryptophan depletion in healthy adults. Biol. Psychiatry 2004, 56:531-534.
15. Uher R., McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol. Psychiatry 2010, 15:18-22.