Microfluidic system for transmission electron microscopy

Microscopy and Microanalysis

Volumn 16, Issue 5, 2010, Pages 622-629

  Ring, Elisabeth A ^a   De Jonge, Niels ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

electron microscopy; liquid flow; microscopy of cells; nanoparticles; scanning transmission electron microscopy; water

Indexed keywords

ARTICLE; BACTERIUM; EUKARYOTIC CELL; METABOLISM; METHODOLOGY; MICROFLUIDICS; TRANSMISSION ELECTRON MICROSCOPY;

BACTERIA; EUKARYOTIC CELLS; MICROFLUIDICS; MICROSCOPY, ELECTRON, TRANSMISSION;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 79551490719     PISSN: 14319276     EISSN: 14358115     Source Type: Journal    
DOI: 10.1017/S1431927610093669     Document Type: Article

References (19)

1. Abrams, I.M. & amp; McBain, J.W. (1944). A closed cell for electron microscopy. J Appl Phys 15, 607-609.
2. Bao, J.B. & amp; Harrison, D.J. (2006).Measurement of flow in microfluidic networks with micrometer-sized flow restrictors. AIChE J 52(1), 75-85.
3. Crewe, A.V., Wall, J. & amp; Langmore, J. (1970). Visibility of single atoms. Science 168, 1338-1340.
4. Daulton, T.L., Little, B.J., Lowe, K. & amp; Jones-Meehan, J. (2001). In situ environmental cell-transmission electron microscopy study of microbial reduction of chromium-VI! using electron energy loss spectroscopy. Microsc Microanal,7,470-485.
5. de Jonge, N., Peckys, D.B., Kremers, G.J. & amp; Piston, D.W. (2009). Electron microscopy of whole cells in liquid with nanometer resolution. Proc Natl Acad Sci 106, 2159-2164.
6. de Jonge, N., Peckys, D.B., Veith, G.M., Mick, S., Pennycook, S.J. & amp; Joy, C.S. (2007). Scanning transmission electron microscopy of samples in liquid -liquid STEM!. Microsc Microanal 13-S2!, 242-243.
7. de Jonge, N., Poirier-Demers, N., Peckys, D.B. & amp; Drouin, D. (2010). Nanometer-resolution electron microscopy through micrometers-thick water layers. Ultramicroscopy 110(9), 1114-1119.
8. Easley, C.J. (2006). Development and application of microfluidic genetic analysis systems. Dissertation in Chemistry. Charlottesville, VA: University of Virginia.
9. Einstein, A. (1905). On the motion-required by the molecular kinetic theory of heat-of small particles suspended in a stationary liquid. Ann Phys 17, 549-560.
10. Kirk, S.E., Shepper, J.N. & amp; Donald, A.M. (2009). Application of environmental scanning electron microscopy to determine biological surface structure. J Microsc 233, 205-244.
11. Liu, K.L.,Wu, C.C., Huang, Y.J., Peng, H.L., Chang, H.Y., Chang, P., Hsu, L. & amp; Yew, T.R. (2008). Novel microchip for in situ TEM imaging of living organisms and bio-reactions in aqueous conditions. Lab Chip 8, 1915-1921.
12. Longwell, P.A. (1966).Mechanics of Fluid Flow. NewYork:McGraw Hill.
13. Nishiyama, H., Sugo, M., Ogura, T., Maruyama, Y., Koizumi, M., Mio, K., Kitamura, S. & amp; Sato, C. (2010). Atmospheric scanning electron microscope observes cells and tissues in open medium through silicon nitride film. J Struct Biol 169(3), 438-439.
14. Parsons, D.F., Matricardi, V.R., Moretz, R.C. & amp; Turner, J.N. (1974). Electron microscopy and diffraction of wet unstained and unfixed biological objects. Adv Biol Med Phys 15, 161-270.
15. Peckys, D.B., Veith, G.M., Joy, D.C. & amp; de Jonge, N. (2009). Nanoscale imaging of whole cells using a liquid enclosure and a scanning transmission electron microscope. PLoS One 4(12), e8214.
16. Thiberge, S., Nechushtan, A., Sprinzak, D., Gileadi, O., Behar, V., Zik, O., Chowers, Y., Michaeli, S., Schlessinger, J. & amp; Moses, E. (2004). Scanning electron microscopy of cells and tissues under fully hydrated conditions. Proc Natl Acad Sci 101(10), 3346.
17. Williamson, M.J., Tromp, R.M., Vereecken, P.M., Hull, R. & Ross, F.M. (2003). Dynamic microscopy of nanoscale cluster growth at the solid-liquid interface. Nat Mater 2, 532-536.
18. Xiao, Y., Patolsky, F., Katz, E., Hainfeld, J.F. & amp; Willner, I. (2003). "Plugging into enzymes": Nanowiring of redox enzymes by a gold nanoparticle. Science 299, 1877-1881.
19. Zheng, H., Smith, R.K., Jun, Y.W., Kisielowski, C., Dahmen, U. & amp; Alivisatos, A.P. (2009). Observation of single colloidal platinum nanocrystal growth trajectories. Science 324(5932), 1309-1312.