Unraveling the role of connective tissue growth factor in diabetic nephropathy

Kidney International

Volumn 73, Issue 4, 2008, Pages 375-376

  Schmidt Ott, K M ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR;

CELL DIFFERENTIATION; CELL MIGRATION; CELL SURVIVAL; DIABETIC NEPHROPATHY; EXTRACELLULAR MATRIX; GLOMERULUS; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY INJURY; MITOGENESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NOTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEINURIA; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 38749118641     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5002661     Document Type: Note

References (13)

1. Forbes JM, Fukami K, Cooper ME. Diabetic nephropathy: where hemodynamics meets metabolism. Exp Clin Endocrinol Diabetes 2007; 115: 69-84.
2. Wolf G, Chen S, Ziyadeh FN. From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy. Diabetes 2005; 54: 1626-1634.
3. Murphy M, Godson C, Cannon S et al. Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem 1999; 274: 5830-5834.
4. Furlong F, Crean J, Thornton L et al. Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose. Am J Physiol Renal Physiol 2007; 292: F1691-F1700.
5. Guha M, Xu ZG, Tung D et al. Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes. FASEB J 2007; 21: 3355-3368.
6. Yokoi H, Mukoyama M, Mori K et al. Overexpression of connective tissue growth factor in podocytes deteriorates diabetic nephropathy in mice. Kidney Int 2008; 73: 446-455.
7. Abreu JG, Ketpura NI, Reversade B et al. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 2002; 4: 599-604.
8. Patel SR, Dressler GR. BMP7 signaling in renal development and disease. Trends Mol Med 2005; 11: 512-518.
9. Wang S, de Caestecker M, Kopp J et al. Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol 2006; 17: 2504-2512.
10. Wahab NA, Weston BS, Mason RM. Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA. J Am Soc Nephrol 2005; 16: 340-351.
11. Lau LF, Lam SC. The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res 1999; 248: 44-57.
12. Mercurio S, Latinkic B, Itasaki N et al. Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex. Development 2004; 131: 2137-2147.
13. Lin CL, Wang JY, Huang YT et al. Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells. J Am Soc Nephrol 2006; 17: 2812-2820.