Alpinumisoflavone induces apoptosis and suppresses extracellular signal-regulated kinases/mitogen activated protein kinase and nuclear factor-κB pathways in lung tumor cells

Biological and Pharmaceutical Bulletin

Volumn 34, Issue 2, 2011, Pages 203-208

  Namkoong, Sim ^a   Kim, Tack Joong ^a   Jang, Ik Soon ^b   Kang, Keon Wook ^c   Oh, Won Keun ^c   Park, Junsoo ^a  

^a Yonsei University Wonju   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c Chosun University   (South Korea)

Author keywords

Alpinumisoflavone; Erythrina lysistemon; Extracellular signal regulated kinase; Lung cancer; Nuclear factor B

Indexed keywords

ALPINUMISOFLAVONE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE G1 PHASE; CELL STRAIN; CELL STRAIN RAW 264.7; CELL SUBPOPULATION; CONTROLLED STUDY; DRUG ISOLATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; LUNG CANCER; NONHUMAN; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CELL CYCLE; CELL LINE, TUMOR; ERYTHRINA; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; HUMANS; ISOFLAVONES; LIPOPOLYSACCHARIDES; LUNG NEOPLASMS; MICE; NF-KAPPA B; NITRIC OXIDE; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; SIGNAL TRANSDUCTION;

EID: 79551475057     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.34.203     Document Type: Article

References (19)

1. Sebolt-Leopold J. S., Herrera R., Nat. Rev. Cancer, 4, 937-947 (2004).
2. Lee K. W., Kang N. J., Heo Y. S., Rogozin E. A., Pugliese A., Hwang M. K., Bowden G. T., Bode A. M., Lee H. J., Dong Z., Cancer Res., 68, 946-955 (2008).
3. Gupta S. C., Sundaram C., Reuter S., Aggarwal B. B., Biochim. Biophys. Acta, 1799, 775-787 (2010).
4. Perkins N. D., Nat. Rev. Mol. Cell Biol., 8, 49-62 (2007).
5. Karin M., Nature (London), 441, 431-436 (2006).
6. el-Masry S., Amer M. E., Abdel-Kader M. S., Zaatout H. H., Phytochemistry, 60, 783-787 (2002).
7. Han X. H., Hong S. S., Hwang J. S., Jeong S. H., Hwang J. H., Lee M. H., Lee M. K., Lee D., Ro J. S., Hwang B. Y., Arch. Pharm. Res., 28, 1324-1327 (2005).
8. Na M., Jang J., Njamen D., Mbafor J. T., Fomum Z. T., Kim B. Y., Oh W. K., Ahn J. S., J. Nat. Prod., 69, 1572-1576 (2006).
9. Liu Y., Veena C. K., Morgan J. B., Mohammed K. A., Jekabsons M. B., Nagle D. G., Zhou Y. D., J. Biol. Chem., 284, 5859-5868 (2009).
10. Oh W. K., Lee C., Seo J. H., Chung M. Y., Cui L., Fomum Z. T., Kang J. S., Lee H. S., Arch. Pharm. Res., 32, 43-47 (2009).
11. Park K., Kim K., Rho S. B., Choi K., Kim D., Oh S. H., Park J., Lee S. H., Lee J. H., Cancer Res., 65, 749-757 (2005).
12. Shin S., Sung B. J., Cho Y. S., Kim H. J., Ha N. C., Hwang J. I., Chung C. W., Jung Y. K., Oh B. H., Biochemistry, 40, 1117-1123 (2001).
13. Lee Y. W., Hennig B., Yao J., Toborek M., J. Neurosci. Res., 66, 583-591 (2001).
14. Chae M., Kim K., Park S. M., Jang I. S., Seo T., Kim D. M., Kim I. C., Lee J. H., Park J., Biochem. Biophys. Res. Commun., 370, 519-524 (2008).
15. Park J., Kim K., Lee E. J., Seo Y. J., Lim S. N., Park K., Rho S. B., Lee S. H., Lee, J. H., Proc. Natl. Acad. Sci. U.S.A., 104, 17028-17033 (2007).
16. Park J., Seo T., Hwang S., Lee D., Gwack Y., Choe J., J. Virol., 74, 11977-11982 (2000).
17. Xie Q. W., Kashiwabara Y., Nathan C., J. Biol. Chem., 269, 4705-4708 (1994).
18. Ai Z., Yin L., Zhou X., Zhu Y., Zhu D., Yu Y., Feng Y., Cancer, 107, 746-756 (2006).
19. Kumar P., Coltas I. K., Kumar B., Chepeha D. B., Bradford C. R., Polverini P. J., Cancer Res., 67, 1193-1202 (2007).