The expression of dynein light chain DYNLL1 (LC8-1) is persistently downregulated in glaucomatous rat retinal ganglion cells

Experimental Eye Research

Volumn 92, Issue 2, 2011, Pages 138-146

  van Oterendorp, Christian ^a,b   Lorber, Barbara ^a   Jovanovic, Zorica ^c   Yeo, Giles ^c   Lagrèze, Wolf A ^b   Martin, Keith R ^a,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d Cambridge NIHR Biomedical Research Centre   (United Kingdom)

Author keywords

Apoptosis; Axonal transport; Dynein; Dynein light chain; DYNLL; Glaucoma; Retinal ganglion cell

Indexed keywords

RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; AQUEOUS HUMOR OUTFLOW; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DYNLL1 GENE; DYNLL2 GENE; GENE; GENE EXPRESSION; GLAUCOMA; IMMUNOHISTOCHEMISTRY; INTRAOCULAR PRESSURE; LASER CAPTURE MICRODISSECTION; LIGHT CHAIN; LOW LEVEL LASER THERAPY; MALE; NERVE CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PURIFICATION; RETINA; RETINA GANGLION CELL;

ANIMALS; CYTOPLASMIC DYNEINS; DOWN-REGULATION; GLAUCOMA; IMMUNOENZYME TECHNIQUES; INTRAOCULAR PRESSURE; MALE; MODELS, ANIMAL; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; RETINAL GANGLION CELLS; RNA, MESSENGER;

EID: 79451470965     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2010.11.013     Document Type: Article

References (34)

1. Barbar E. Dynein light chain LC8 is a dimerization hub essential in diverse protein networks. Biochemistry 2008, 47:503-508.
2. Barron M.J., Griffiths P., Turnbull D.M., Bates D., Nichols P. The distributions of mitochondria and sodium channels reflect the specific energy requirements and conduction properties of the human optic nerve head. Br. J. Ophthalmol. 2004, 88:286-290.
3. Benison G., Nyarko A., Barbar E. Heteronuclear NMR identifies a nascent helix in intrinsically disordered dynein intermediate chain: implications for folding and dimerization. J. Mol. Biol. 2006, 362:1082-1093.
4. Bull N.D., Irvine K.A., Franklin R.J., Martin K.R. Transplanted oligodendrocyte precursor cells reduce neurodegeneration in a model of glaucoma. Invest. Ophthalmol. Vis. Sci. 2009, 50:4244-4253.
5. Bull N.D., Limb G.A., Martin K. Human Muller stem cell (MIO-M1) transplantation in a rat model of glaucoma: survival, differentiation and integration. Invest. Ophthalmol. Vis. Sci. 2008.
6. Chang Y.W., Jakobi R., McGinty A., Foschi M., Dunn M.J., Sorokin A. Cyclooxygenase 2 promotes cell survival by stimulation of dynein light chain expression and inhibition of neuronal nitric oxide synthase activity. Mol. Cell Biol. 2000, 20:8571-8579.
7. Chen Y.M., Gerwin C., Sheng Z.H. Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial docking in axons. J. Neurosci. 2009, 29:9429-9438.
8. Cui Q., Yip H.K., Zhao R.C., So K.F., Harvey A.R. Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons. Mol. Cell. Neurosci. 2003, 22:49-61.
9. Day C.L., Puthalakath H., Skea G., Strasser A., Barsukov I., Lian L.Y., Huang D.C., Hinds M.G. Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochem. J. 2004, 377:597-605.
10. Dietz G.P., Schott M., Labes M., Bahr M. Expression of the protein inhibitor of nitric oxide synthase in the adult rat retina before and after optic nerve lesion. Brain Res. Mol. Brain Res. 2005, 136:118-124.
11. Fan J., Zhang Q., Tochio H., Li M., Zhang M. Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain. J. Mol. Biol. 2001, 306:97-108.
12. Fournier A.E., McKerracher L. Expression of specific tubulin isotypes increases during regeneration of injured CNS neurons, but not after the application of brain-derived neurotrophic factor (BDNF). J. Neurosci. 1997, 17:4623-4632.
13. Gillardon F., Krep H., Brinker G., Lenz C., Bottiger B., Hossmann K.A. Induction of protein inhibitor of neuronal nitric oxide synthase/cytoplasmic dynein light chain following cerebral ischemia. Neuroscience 1998, 84:81-88.
14. Guo Y., Cepurna W.O., Dyck J.A., Doser T.A., Johnson E.C., Morrison J.C. Retinal cell responses to elevated intraocular pressure: a gene array comparison between the whole retina and retinal ganglion cell layer. Invest. Ophthalmol. Vis. Sci. 2010, 51:3003-3018.
15. Guo Y., Johnson E., Cepurna W., Jia L., Dyck J., Morrison J.C. Does elevated intraocular pressure reduce retinal TRKB-mediated survival signaling in experimental glaucoma?. Exp. Eye Res. 2009, 89:921-933.
16. Ha J., Lo K.W., Myers K.R., Carr T.M., Humsi M.K., Rasoul B.A., Segal R.A., Pfister K.K. A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes. J. Cell. Biol. 2008, 181:1027-1039.
17. Heerssen H.M., Pazyra M.F., Segal R.A. Dynein motors transport activated Trks to promote survival of target-dependent neurons. Nat. Neurosci. 2004, 7:596-604.
18. Johnson T.V., Bull N.D., Hunt D.P., Marina N., Tomarev S.I., Martin K.R. Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 2010, 51:2051-2059.
19. Klocker N., Cellerino A., Bahr M. Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells in vivo. J. Neurosci. 1998, 18:1038-1046.
20. Levkovitch-Verbin H., Dardik R., Vander S., Nisgav Y., Kalev-Landoy M., Melamed S. Experimental glaucoma and optic nerve transection induce simultaneous upregulation of proapoptotic and prosurvival genes. Invest. Ophthalmol. Vis. Sci. 2006, 47:2491-2497.
21. Levkovitch-Verbin H., Quigley H.A., Martin K.R., Valenta D., Baumrind L.A., Pease M.E. Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats. Invest. Ophthalmol. Vis. Sci. 2002, 43:402-410.
22. Libby R.T., Li Y., Savinova O.V., Barter J., Smith R.S., Nickells R.W., John S.W. Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet. 2005, 1:17-26.
23. Manabe S., Gu Z., Lipton S.A. Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death. Invest. Ophthalmol. Vis. Sci. 2005, 46:4747-4753.
24. Martin K.R., Quigley H.A., Valenta D., Kielczewski J., Pease M.E. Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma. Exp. Eye Res. 2006, 83:255-262.
25. Myers K.R., Lo K.W., Lye R.J., Kogoy J.M., Soura V., Hafezparast M., Pfister K.K. Intermediate chain subunit as a probe for cytoplasmic dynein function: biochemical analyses and live cell imaging in PC12 cells. J. Neurosci. Res. 2007, 85:2640-2647.
26. Nyarko A., Hare M., Hays T.S., Barbar E. The intermediate chain of cytoplasmic dynein is partially disordered and gains structure upon binding to light-chain LC8. Biochemistry 2004, 43:15595-15603.
27. Pfister K.K., Salata M.W., Dillman J.F., Vaughan K.T., Vallee R.B., Torre E., Lye R.J. Differential expression and phosphorylation of the 74-kDa intermediate chains of cytoplasmic dynein in cultured neurons and glia. J. Biol. Chem. 1996, 271:1687-1694.
28. Phillis R., Statton D., Caruccio P., Murphey R.K. Mutations in the 8 kDa dynein light chain gene disrupt sensory axon projections in the Drosophila imaginal CNS. Development 1996, 122:2955-2963.
29. Quigley H.A. New paradigms in the mechanisms and management of glaucoma. Eye 2005, 19:1241-1248.
30. Quigley H.A., Nickells R.W., Kerrigan L.A., Pease M.E., Thibault D.J., Zack D.J. Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest. Ophthalmol. Vis. Sci. 1995, 36:774-786.
31. Song C., Wen W., Rayala S.K., Chen M., Ma J., Zhang M., Kumar R. Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. J. Biol. Chem. 2008, 283:4004-4013.
32. Tezel G. Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog. Retin. Eye Res. 2006, 25:490-513.
33. Tung Y.C., Ma M., Piper S., Coll A., O'Rahilly S., Yeo G.S. Novel leptin-regulated genes revealed by transcriptional profiling of the hypothalamic paraventricular nucleus. J. Neurosci. 2008, 28:12419-12426.
34. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002, 3(7). RESEARCH0034.