Exenatide: NMR/CD evaluation of the medium dependence of conformation and aggregation state

Biopolymers - Peptide Science Section

Volumn 76, Issue 4, 2004, Pages 298-308

  Hudson, F Michael ^a   Andersen, Niels H ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

CD; Exendin 4; Helical propensity; Helix bundle formation; Tertiary structure; Trp cage formation

Indexed keywords

AGGLOMERATION; BLOOD; CONFORMATIONS; DISEASE CONTROL; DRUG THERAPY; GLUCOSE; MIXTURES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

DIABETES; POSTMEAL GLUCOSE CONCENTRATION; THERAPEUTIC AGENTS;

POLYPEPTIDES;

EXENDIN 4; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

CIRCULAR DICHROISM; CONFERENCE PAPER; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE ANALYSIS; PH; PROTEIN AGGREGATION; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; CIRCULAR DICHROISM; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN CONFORMATION; VENOMS;

EID: 7944227040     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.20126     Document Type: Conference Paper

References (17)

1. Eng, J.; Kleinman, W. A.; Singh, L.; Singh, G.; Raufman, J. P. J Biol Chem 1992, 267, 7402-7405.
2. Göke, R.; Fehmann, H. C.; Linn, T.; Schmidt, H.; Krause, M.; Eng, J.; Göke, B. J Biol Chem 1993, 268, 19650-19655.
3. Young, A. A.; Gedulin, B. R.; Bhavsar, S.; Bodkin, N.; Jodka, C.; Hansen, B.; Denaro, M. Diabetes 1999, 48 1026-1034.
4. Andersen, N. H.; Brodsky, Y.; Neidigh, J. W.; Prickett, K. Bioorg Med Chem 2002, 10, 79-85.
5. Neidigh, J. W.; Fesinmeyer, R. M.; Prickett, K. S.; Andersen, N. H. Biochemistry 2001, 40, 13188-13200.
6. Neidigh, J. W.; Andersen, N. H. Biopolymers 2002, 65, 354-361.
7. Neidigh, J. W.; Fesinmeyer, R. M.; Andersen, N. H. Nature Struct Biol 2002, 9, 425-430.
8. Bruch, M. D.; Dhingra, M. M.; Gierasch, L. M. Proteins 1991, 10, 130-139.
9. Muñoz, V.; Serrano, L.; Jiménez, M. A.; Rico, M. J Mol Biol 1995, 247, 648-669.
10. Andersen, N. H.; Liu, Z.; Prickett, K. S. FEBS Lett 1996, 399, 47-52.
11. Andersen, N. H.; Neidigh, J.; Harris, S. M.; Lee, G. M.; Liu, Z.; Tong, H. J Am Chem Soc 1997, 119, 8547-8561.
12. Fesinmeyer, R. M.; Hudson, F. M.; Andersen, N. H. J Am Chem Soc 2004, 126, 7238-7243.
13. Bundi, A.; Grathwohl, C.; Hochmann, J.; Keller, R. M.; Wagner, G.; Wûthrich, K. J Magn Reson 1975, 18, 191-198.
14. Wishart, D. S.; Sykes, B. D. Methods Enzymol 1994, 239, 311-333.
15. Andersen, N. H.; Tong, H. Protein Sci 1997, 6, 1920-1936.
16. Barua, B.; Andersen, N. H. Lett Peptide Sci 2002, 8, 221-226.
17. Qui, L.; Pabit, S. A.; Roitberg, A. E.; Hagen, S. J. J Am Chem Soc 2002, 124, 12952-12953.