Neonatal seizures: Diagnosis, pharmacologic interventions, and outcomes

Journal of Perinatal and Neonatal Nursing

Volumn 18, Issue 3, 2004, Pages 275-287

  Granelli, Sheri L P ^a,c   McGrath, Jacqueline M ^b  

^a Phoenix Perinatal Associates   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c NONE   (United States)

Author keywords

Neonatal seizures; Neonate; Neurologic

Indexed keywords

CARBAMAZEPINE; DIAZEPAM; FLUMAZENIL; FOSPHENYTOIN SODIUM; LIDOCAINE; LORAZEPAM; MIDAZOLAM; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; ROMAXICON; VALPROIC ACID; VIGABATRIN; ANTICONVULSIVE AGENT;

APNEA; BRADYCARDIA; CARNITINE DEFICIENCY; CLINICAL FEATURE; DIAGNOSTIC IMAGING; DISEASE CLASSIFICATION; DISEASE SEVERITY; FAMILY HISTORY; HEART ARREST; HUMAN; HYPERAMMONEMIA; HYPOTENSION; LABORATORY TEST; LIVER TOXICITY; MEDICAL DECISION MAKING; MYOCLONUS SEIZURE; NERVOUSNESS; PATHOPHYSIOLOGY; PRACTICE GUIDELINE; PROGNOSIS; RESPIRATORY ARREST; REVIEW; SEDATION; SEIZURE; SIDE EFFECT; TONIC SEIZURE; TREATMENT OUTCOME; BRAIN; CONGENITAL MALFORMATION; DIFFERENTIAL DIAGNOSIS; DYSKINESIA; EPILEPSY; NEWBORN; NEWBORN DISEASE; RISK FACTOR; TIME;

ANTICONVULSANTS; BRAIN; DIAGNOSIS, DIFFERENTIAL; DYSKINESIAS; EPILEPSY; HUMANS; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; RISK FACTORS; SEIZURES; TIME FACTORS;

EID: 7944222452     PISSN: 08932190     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005237-200407000-00009     Document Type: Review

References (38)

1. Rennie JM, Boylan GB. Neonatal seizures and their treatment. Curr Opin Neurol. 2003;16:177-181.
2. Mizrahi E. Acute and chronic effects of seizures in the developing brain: lessons from clinical experience. Epilepsia. 1999;40(suppl 1);S42-S50.
3. Bernes SM, Kaplan AM. Evolution of the neonatal seizures. Pediatr Clin North Am. 1994;41(5):1069-1104.
4. Fenichel GM. Clinical Pediatric Neurology. 2nd ed. Philadelphia: Saunders; 1993:5.
5. Fenichel GM. Neonatal Neurology. 3rd ed. New York: Churchill Livingston; 1990.
6. Landrot IR, Minokoshi M, Silveira DC, Cha BH, Holmes GL. Recurrent neonatal seizures: relationship of pathology to the electroencephalogram and cognition. Dev Brain Res. 2001;129:27-38.
7. Sogawa Y, Monokoshi M, Silveira DC, et al. Timing of cognitive deficits following, neonatal seizures: relationship to histological changes in the hippocampus. Dev Brain Res. 2001;131:73-83.
8. Hermann B, Seidenberg M, Bell B, et al. The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function. Epilepsia. 2002;43(9):1062-1071.
9. Sutula TP, Hagen J, Pitkanen A. Do epileptic seizures damage the brain? Curr Opin Neurol. 2003;16:189-195.
10. Holmes GL, Khazipov R, Ben-Ari Y. New concepts in neonatal seizures. NeuroReport. 2002;13(1):A3-A8.
11. Scher MS. Neonatal seizures and brain damage. Pediatr Neurol. 2003;29(5):381-390.
12. Volpe JJ. Neurology of the Newborn. 4th ed. Philadelphia: Saunders; 2001.
13. Mizrahi EM, Kellaway P. Diagnosis and Management of Neonatal Seizures. Philadephia:Lippincott-Rave; 1998.
14. Mizrahi E. Neonatal seizures and neonatal epileptic syndromes. Neurol Clin. 2001;19(2):427-463.
15. Evans D, Levene M. Neonatal seizures. Arch Dis Child. Fetal Neonatal Ed. 1998;78:F70-F75.
16. Klawitter M. Neonatal seizures. Mother Baby J. 1999;4(5):7-13.
17. Painter MJ, Scher MS, Stein AD, et al. Phenobarbital compared with phenytoin for the treatment of neonatal seizures. New Engl J Med. August 12, 1999;341:485-489.
18. Young TE, Mangum B. Neofax®: A Manual of Drugs Used in Neonatal Care. 16th ed. Raleigh, NC: Acorn Publishing; 2003.
19. Zenk KE, Sills JH, Koeppel RM. Neonatal Medications & Nutrition: A Comprehensive Guide. 3rd ed. Santa Rosa, Calif: NICU Ink; 2003.
20. Sharief N, Goonasekera C. Soft tissure injury associated with intravenous phenytoin in a neonate. Acta Paediatr. 1994;83(11):1218-1219.
21. Wheless JW. Pediatric use of intravenous and intramuscular phenytion: Lessons learned. J Child Neurol. 1998;13(suppl 1):S30-S32.
22. Pereira-da-Silva L, Henriques G, Videira-Amaral JM, Rodriques R, Riberiro L, Virella D. Osmolality of solutions, emulsions and drugs that may have a high osmololity: aspects of their use in neonatal care. J Matern Fetal Neonatal Med. 2002;11(5):333-338.
23. Kriel RL, Cifuentes RF. Fosphenytoin in infants of extremely low birth weight. Pediatr Neurol. 2001;24(3):219-221.
24. Fischer JH, Patel TV, Fischer PA. Fosphenytoin: clinical pharmacokinetics and comparative advantages in the acute treatment of seizures. Clin Pharmacokinet. 2003;42(1):33-58.
25. Smith BT, Masotti RE. Intravenous diazepam in the treatment of prolonged seizure activity in neonates and infants. Dev Med Child Neurol. 1971;13:630-634.
26. Noerr B. Pharmaceutical excipients. Neonatal Netw. 2000;19(6):67-70.
27. Andre M, Bountray MJ, Dubruc O, et al. Clonazepam pharmacokinetics and therapeutic efficacy in neonatal seizures. Eur J Clin Pharmacol. 1986;305:585-589.
28. Singhi S, Murthy A, Singhi D, Jayashree M. Continous midazolam versus diazepam infusion for refractory convulsive status epilepticus. Journal Child Neurol. February 2002;17(2):106-110.
29. Massanari M, Novitsky J, Reinstein LJ. Paradoxical reactions in children associated with midazalam use during endoscopy. Clin Pediatr. 1997;36(12):681-684.
30. Sexson WR, Thigpen J, Stajich GV. Stereotypic movements after lorazepam administration in premature neonates: a series and review of the literature. J Perinatol. 1995;15:146-149.
31. Chess PR, et al. Clonic movements following Lorazepam admistration in full-term infants. Arch Pediatr Adolesc Med. 1998;152(1):98-99.
32. Taketomo CK, Hodding JH, Kraus DM. Lexi-Comp's: Pediatric Dosage Handbook: Including Neonatal Dosing, Drug Administration, & Extemporaneous Preparations. 10th ed. Chicago: Lexi-Comp; 2003.
33. Bergin AM, Connolly M. New antiepileptic drug therapies. Neurol Clin North Am. 2002;20:1163-1182.
34. Kurokawa T. Clinical and EEG findings and prognosis of seizure disorders in children: presidential address. Epilepsia. 1996;37(suppl 3):s2-s4.
35. Scher MS, Kosaburo A, Beggarly ME, Hamid MY, Steppe DA, Painter MJ. Electrographic seizures in preterm and full-term neonates: clinical correlates, associated brain lesions, and risk for neurologic sequelae. Pediatrics. 1993;91(1):128-134.
36. Jensen FE. Acute and chronic effects of seizures in the developing brain: experimental models. Epelepsia. 1999;40(suppl 1):s51-s58.
37. Brunquell PJ, Glennon CM, Dimario FJ, Lerer T, Eisenfield L. Prediction of outcome based on clinical seizure type in newborn infants. J Pediatr. 140:707-712.
38. Screenan C, Bhargava R, Robertosn CMT. Cerebral infaction in the term newborn: clinical presentation and long term outcome. J Pediatr. 2002;137:351-355.