Regulation of electrospun scaffold stiffness via coaxial core diameter

Acta Biomaterialia

Volumn 7, Issue 3, 2011, Pages 1133-1139

  Drexler, J W ^a   Powell, H M ^a  

^a Ohio State University   (United States)

Author keywords

Coaxial electrospinning; Gelatin; Mechanical properties; PCL; Scaffold

Indexed keywords

BIOMECHANICS; CROSSLINKING; ELECTROSPINNING; SCAFFOLDS (BIOLOGY); STIFFNESS; SUBSTRATES; SURFACE CHEMISTRY;

CELLULAR BEHAVIORS; COAXIAL ELECTROSPINNING; CONCENTRATION RATES; CORE DIAMETERS; CROSS-LINKING POLYMERS; ELECTROSPUN SCAFFOLDS; FEEDRATE; FIBER DIAMETERS; GELATIN; SOLUTION CONCENTRATION;

POLYCAPROLACTONE;

GELATIN; POLYCAPROLACTONE; TISSUE SCAFFOLD;

ARTICLE; CHEMICAL STRUCTURE; ELECTROSPINNING; FIBER; LASER MICROSCOPY; PRIORITY JOURNAL; RIGIDITY; SCANNING ELECTRON MICROSCOPY; TENSILE STRENGTH; TISSUE ENGINEERING; TRANSMISSION ELECTRON MICROSCOPY;

EID: 79251645599     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.10.025     Document Type: Article

References (36)

1. R.G. Wells The role of matrix stiffness in regulating cell behavior Hepatology 47 2008 1394 1400
2. D.E. Discher, P. Janmey, and Y.-L. Wang Tissue cells feel and respond to the stiffness of their substrate Science 310 2005 1139 1143
3. R.J. Pelham, and Y.-L. Wang Cell locomotion and focal adhesions are regulated by substrate flexibility Proc Natl Acad Sci 94 1997 13661 13665
4. B. Cortese, G. Gigli, and M. Riehle Mechanical gradient cues for guided cell motility and control of cell behavior on uniform substrates Adv Funct Mater 19 2009 2961 2968
5. C.-M. Lo, H.-B. Wang, M. Dembo, and Y.-L. Wang Cell movement is guided by the rigidity of the substrate Biophys J 79 2000 144 152
6. N.D. Leipzig, and M.S. Shoichet The effect of substrate stiffness on adult neural stem cell behavior Biomaterials 30 2009 6867 6878
7. Y.S. Pek, A.C. Wan, and J.Y. Ying The effect of matrix stiffness on mesenchymal stem cell differentiation in a three-dimensional thixotropic gel Biomaterials 31 2010 385 391
8. M. Levy-Mishali, J. Zoldan, and S. Levenberg Effect of scaffold stiffness on myoblast differentiation Tissue Eng 15 2009 935 944
9. N. Zaari, P. Rajagopalan, S.K. Kim, A.J. Engler, and J.Y. Wong Photopolymerization in microfluidic gradient generators: microscale control of substrate compliance to manipulate cell response Adv Mater 16 2004 2133 2137
10. J.M. Collins, P. Ayala, T.A. Desai, and B. Russell Three-dimensional culture with stiff microstructures increases proliferation and slows osteogenic differentiation of human mesenchymal stem cells Small 6 2010 355 360
11. A. Subramanian, and H.Y. Lin Crosslinked chitosan: its physical properties and the effects of matrix stiffness on chondrocyte cell morphology and proliferation J Biomed Mater Res 75A 2005 742 753
12. D. Dikovsky, H. Bianco-Peled, and D. Seliktar Defining the role of matrix compliance and proteolysis in three-dimensional cell spreading and remodeling Biophys J 94 2008 2914 2925
13. H.M. Powell, and S.T. Boyce Engineered human skin fabricated using electrospun collagen-PCL blends: morphogenesis and mechanical properties Tissue Eng 15 2009 2177 2187
14. R. Glicklis, L. Shapiro, R. Agabaria, J. Merchuk, and S. Cohen Hepatocyte behavior within three-dimensional porous alginate scaffolds Biotechnol Bioeng 67 2000 44
15. T. Ma, Y. Li, S.T. Yang, and D. Kniss Effects of pore size in 3-D fibrous matrix on human trophoblast tissue development Biotechnol Bioeng 70 2000 606 618
16. H. Wang, J. Pieper, F. Peters, C. vanBlitterswijk, and E. Lamme Synthetic scaffold morphology controls human dermal connective tissue formation J Biomed Mater Res A 74A 2005 523 532
17. A. Salem, R. Stevens, R. Pearson, M. Davies, S. Tendler, and C. Roberts Interaction of 3T3 fibroblasts and endothelial cells with defined pore features J Biomed Mater Res 61 2002 212 217
18. K.B. McClary, T. Ugarova, and D.W. Grainger Modulating fibroblast adhesion, spreading, and proliferation using self-assembled monolayer films of alkylthiolates on gold J Biomed Mater Res 50 2000 428 439
19. S.J. Bryant, K.S. Anseth, D.A. Lee, and D.L. Bader Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain J Orthopaed Res 22 2004 1143 1149
20. D. Li, A. Babel, S.A. Jenekhe, and Y. Xia Nanofibers of conjugated polymers prepared by electrospinning with a two-capillary spinneret Adv Mater 16 2004 2062
21. Z. Sun, E. Zussman, A.L. Yarin, J.H. Wendorff, and A. Greiner Compound core-shell polymer nanofibers by co-electrospinning Adv Mater 15 2003 1929 1932
22. Y. Zhang, Z.-M. Huang, X. Xu, C.T. Lim, and S. Ramakrishna Preparation of core-shell structured PCL-r-Gelatin bi-component nanofibers by coaxial electrospinning Chem Mater 16 2004 3406 3409
23. H.L. Jiang, Y.Q. Hu, Y. Li, P.C. Zhao, K.J. Zhu, and W.L. Chen A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents J Control Rel 108 2005 230 243
24. D. Han, S.T. Boyce, and A.J. Steckl Versatile core-sheath biofibers using coaxial electrospinning Mater Res Soc 1094 2008 1 6
25. Z. Huang, Y. Zhang, and S. Ramakrishna Double-layered composite nanofibers and their mechanical performance J Poly Sci B Poly Phys 43 2005 2852 2861
26. M. Wang, J. Yu, D. Kaplan, and G. Rutledge Production of submicron diameter silk fibers under benign processing conditions by two-fluid electrospinning Macromol 39 2006 1102 1107
27. P. Zhao, H. Jiang, H. Pan, K. Zhu, W. Chen, and P. Zhao Biodegradable fibrous scaffolds composed of gelatin coated poly(epsilon-caprolactone) prepared by coaxial electrospinning J Biomed Mater Res A 83A 2007 372 382
28. A. Balguid, A. Mol, M.H. van Marion, R.A. Bank, C.V.C. Bouten, and F.P.T. Baaijens Tailoring fiber diameter in electrospun polycaprolactone scaffolds for optimal cellular infiltration in cardiovascular tissue engineering Tissue Eng 15 2009 437 444
29. V. Jacobs, R.D. Anandjiwala, and M. Maaza The influence of electrospinning parameters on the structural morphology and diameter of electrospun nanofibers J Appl Polym Sci 115 2010 3130 3136
30. M. Chen, P.K. Patra, S.B. Warner, and S. Bhowmick Role of fiber diameter in adhesion and proliferation of NIH 3T3 fibroblast on electrospun polycaprolactone scaffolds Tissue Eng 13 2007 579 587
31. J.M. Deitzel, J. Kleinmeyer, D. Harris, and N.C.B. Tan The effect of processing variables on the morphology of electrospun nanofibers and textiles Polymer 42 2001 261 272
32. H.M. Powell, and S.T. Boyce Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes J Biomed Mater Res 84A 2007 1078 1086
33. J. Shawon, and C. Sung Electrospinning of polycarbonate nanofibers with solvent mixtures THF and DMF J Mater Sci 39 2004 4605 4613
34. K.H. Lee, H.Y. Kim, Y.M. La, D.R. Lee, and N.H. Sung Influence of a mixing solvent with tetrahydrofuran and N,N-dimethylformamide on electrospun poly(vinyl chloride) nonwoven mats J Polym Sci 40 2002 2259 2268
35. S. Koombhongse, W. Liu, and D.H. Reneker Flat polymer ribbons and other shapes by electrospinning J Polym Sci 39 2001 2598 2606
36. S. Soliman, S. Pagliari, A. Rinaldi, G. Forte, R. Fiaccavento, and F. Pagliari Multiscale three-dimensional scaffolds for soft tissue engineering via multimodal electrospinning Acta Biomater 6 2010 1227 1237