Synthesis of a tritium-labeled photo-affinity probe based on an atypical leukotriene biosynthesis inhibitor

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 54, Issue 1, 2011, Pages 43-50

  Kumar, Nag S ^a   Braun, Matthew P ^b   Chaudhary, Ashok G ^b   Young, Robert N ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

5 lipoxygenase; leukotriene; photo affinity labeling; tritiation

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; IMAGE PROCESSING; PROTEINS; TRITIUM;

5-LIPOXYGENASE; ATYPICALS; BIOSYNTHESIS INHIBITORS; DIAZIRINES; LABELINGS; LEUKOTRIEN; LIPOXYGENASES; PHOTO-AFFINITY LABELING; PROBE-BASED; TRITIATION;

PROBES;

4 BROMO 5 (4 HYDROXYTETRAHYDROPYRAN 4 YL) 2 (METHYLTHIO)THIAZOLE; 4 BROMO 5 (4 METHOXYTETRAHYDROPYRAN 4 YL) 2 (4 (3 (TRIFLUOROMETHYL) DIAZIRIN 3 YL)PHENYLTHIO)THIAZOLE; 4 BROMO 5 (4 METHOXYTETRAHYDROPYRAN 4 YL) 2 (METHYLTHIO)THIAZOLE; 4 IODO 5 (4 METHOXYTETRAHYDROPYRAN 4 YL) 2 (METHYLTHIO)THIAZOLE; 4 IODO 5 (4 METHOXYTETRAHYDROPYRAN 4 YL) 2 [4 (3 (TRIFLUOROMETHYL) DIAZIRIN 3 YL)PHENYLTHIO]THIAZOLE; 5 (4 METHOXYTETRAHYDROPYRAN 4 YL) 2 (4 (2,2,2 TRIFLUORO 1 (HYDROXYIMINO)ETHYL)PHENYLTHIO)THIAZOLE; 5 (4 METHOXYTETRAHYDROPYRAN 4 YL) 2 (4 (3 (TRIFLUOROMETHYL) DIAZIRIN 3 YL)PHENYLTHIO)THIAZOLE; 5 BROMO 2 (4 (3 (TRIFLUOROMETHYL) DIAZIRIN 3 YL)PHENYLTHIO)THIAZOLE; 5 BROMO 2 (METHYLTHIO)THIAZOLE; LEUKOTRIENE; RADIOPHARMACEUTICAL AGENT; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COMPLEX FORMATION; DRUG SYNTHESIS; HYDROGENATION; INFLAMMATORY CELL; PHOTOAFFINITY LABELING; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 79251637307     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1804     Document Type: Article

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