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Volumn 6, Issue 1, 2011, Pages

Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DOXORUBICIN; EARLY GROWTH RESPONSE FACTOR 1; ETOPOSIDE; METHOTREXATE; UROKINASE; UROKINASE RECEPTOR; ANTINEOPLASTIC AGENT; EGR1 PROTEIN, HUMAN;

EID: 79251632187     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016234     Document Type: Article
Times cited : (24)

References (56)
  • 1
    • 68849109737 scopus 로고    scopus 로고
    • Multiinstitutional phase II study of neoadjuvant chemotherapy for osteosarcoma (NECO study) in Japan: NECO-93J and NECO-95J
    • Iwamoto Y, Tanaka K, Isu K, Kawai A, Tatezaki S, et al. (2009) Multiinstitutional phase II study of neoadjuvant chemotherapy for osteosarcoma (NECO study) in Japan: NECO-93J and NECO-95J. J Orthop Sci 14: 397-404.
    • (2009) J Orthop Sci , vol.14 , pp. 397-404
    • Iwamoto, Y.1    Tanaka, K.2    Isu, K.3    Kawai, A.4    Tatezaki, S.5
  • 2
    • 0038518570 scopus 로고    scopus 로고
    • Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651
    • Goorin AM, Schwartzentruber DJ, Devidas M, Gebhardt MC, Ayala AG, et al. (2003) Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol 21: 1574-1580.
    • (2003) J Clin Oncol , vol.21 , pp. 1574-1580
    • Goorin, A.M.1    Schwartzentruber, D.J.2    Devidas, M.3    Gebhardt, M.C.4    Ayala, A.G.5
  • 3
    • 0036795993 scopus 로고    scopus 로고
    • Dose-intense ifosfamide/doxorubicin/cisplatin based chemotherapy for osteosarcoma in adults
    • Patel SJ, Lynch JW, Jr., Johnson T, Carroll RR, Schumacher C, et al. (2002) Dose-intense ifosfamide/doxorubicin/cisplatin based chemotherapy for osteosarcoma in adults. Am J Clin Oncol 25: 489-495.
    • (2002) Am J Clin Oncol , vol.25 , pp. 489-495
    • Patel, S.J.1    Lynch Jr., J.W.2    Johnson, T.3    Carroll, R.R.4    Schumacher, C.5
  • 4
    • 0036467661 scopus 로고    scopus 로고
    • Prognostic factors in high-grade osteosarcoma of the extremities or trunk: An analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols
    • Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, et al. (2002) Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 20: 776-790.
    • (2002) J Clin Oncol , vol.20 , pp. 776-790
    • Bielack, S.S.1    Kempf-Bielack, B.2    Delling, G.3    Exner, G.U.4    Flege, S.5
  • 5
    • 20144380941 scopus 로고    scopus 로고
    • Osteosarcoma: A randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate
    • Meyers PA, Schwartz CL, Krailo M, Kleinerman ES, Betcher D, et al. (2005) Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate. J Clin Oncol 23: 2004-2011.
    • (2005) J Clin Oncol , vol.23 , pp. 2004-2011
    • Meyers, P.A.1    Schwartz, C.L.2    Krailo, M.3    Kleinerman, E.S.4    Betcher, D.5
  • 6
    • 34547945108 scopus 로고    scopus 로고
    • Local recurrence and local control of non-metastatic osteosarcoma of the extremities: A 27-year experience in a single institution
    • Bacci G, Forni C, Longhi A, Ferrari S, Mercuri M, et al. (2007) Local recurrence and local control of non-metastatic osteosarcoma of the extremities: a 27-year experience in a single institution. J Surg Oncol 96: 118-123.
    • (2007) J Surg Oncol , vol.96 , pp. 118-123
    • Bacci, G.1    Forni, C.2    Longhi, A.3    Ferrari, S.4    Mercuri, M.5
  • 7
    • 33846981552 scopus 로고    scopus 로고
    • Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: A randomized phase III trial of the European Osteosarcoma Intergroup
    • Lewis IJ, Nooij MA, Whelan J, Sydes MR, Grimer R, et al. (2007) Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: a randomized phase III trial of the European Osteosarcoma Intergroup. J Natl Cancer Inst 99: 112-128.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 112-128
    • Lewis, I.J.1    Nooij, M.A.2    Whelan, J.3    Sydes, M.R.4    Grimer, R.5
  • 8
    • 13444282673 scopus 로고    scopus 로고
    • Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein
    • Baek SJ, Kim JS, Moore SM, Lee SH, Martinez J, et al. (2005) Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein. Mol Pharmacol 67: 356-364.
    • (2005) Mol Pharmacol , vol.67 , pp. 356-364
    • Baek, S.J.1    Kim, J.S.2    Moore, S.M.3    Lee, S.H.4    Martinez, J.5
  • 9
    • 0028822914 scopus 로고
    • Expression patterns of immediate early transcription factors in human non-small cell lung cancer
    • The Lung Cancer Study Group
    • Levin WJ, Press MF, Gaynor RB, Sukhatme VP, Boone TC, et al. (1995) Expression patterns of immediate early transcription factors in human non-small cell lung cancer. The Lung Cancer Study Group. Oncogene 11: 1261-1269.
    • (1995) Oncogene , vol.11 , pp. 1261-1269
    • Levin, W.J.1    Press, M.F.2    Gaynor, R.B.3    Sukhatme, V.P.4    Boone, T.C.5
  • 10
    • 0030837544 scopus 로고    scopus 로고
    • Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation
    • Huang RP, Fan Y, de Belle I, Niemeyer C, Gottardis MM, et al. (1997) Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation. Int J Cancer 72: 102-109.
    • (1997) Int J Cancer , vol.72 , pp. 102-109
    • Huang, R.P.1    Fan, Y.2    de Belle, I.3    Niemeyer, C.4    Gottardis, M.M.5
  • 11
    • 0028862848 scopus 로고
    • Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain
    • Huang RP, Liu C, Fan Y, Mercola D, Adamson ED (1995) Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain. Cancer Res 55: 5054-5062.
    • (1995) Cancer Res , vol.55 , pp. 5054-5062
    • Huang, R.P.1    Liu, C.2    Fan, Y.3    Mercola, D.4    Adamson, E.D.5
  • 12
    • 0026563921 scopus 로고
    • Three human osteosarcoma cell lines exhibiting different phenotypic expressions
    • Hotta T, Motoyama T, Watanabe H (1992) Three human osteosarcoma cell lines exhibiting different phenotypic expressions. Acta Pathol Jpn 42: 595-603.
    • (1992) Acta Pathol Jpn , vol.42 , pp. 595-603
    • Hotta, T.1    Motoyama, T.2    Watanabe, H.3
  • 13
    • 77349122071 scopus 로고    scopus 로고
    • The knock-down of overexpressed EZH2 and BMI-1 does not prevent osteosarcoma growth
    • Sasaki H, Setoguchi T, Matsunoshita Y, Gao H, Hirotsu M, et al. (2010) The knock-down of overexpressed EZH2 and BMI-1 does not prevent osteosarcoma growth. Oncol Rep 23: 677-684.
    • (2010) Oncol Rep , vol.23 , pp. 677-684
    • Sasaki, H.1    Setoguchi, T.2    Matsunoshita, Y.3    Gao, H.4    Hirotsu, M.5
  • 15
    • 71649083910 scopus 로고    scopus 로고
    • Tumour formation by single fibroblast growth factor receptor 3-positive rhabdomyosarcoma-initiating cells
    • Hirotsu M, Setoguchi T, Matsunoshita Y, Sasaki H, Nagao H, et al. (2009) Tumour formation by single fibroblast growth factor receptor 3-positive rhabdomyosarcoma-initiating cells. Br J Cancer 101: 2030-2037.
    • (2009) Br J Cancer , vol.101 , pp. 2030-2037
    • Hirotsu, M.1    Setoguchi, T.2    Matsunoshita, Y.3    Sasaki, H.4    Nagao, H.5
  • 16
    • 0004105358 scopus 로고    scopus 로고
    • P53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis
    • de Belle I, Huang RP, Fan Y, Liu C, Mercola D, et al. (1999) p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis. Oncogene 18: 3633-3642.
    • (1999) Oncogene , vol.18 , pp. 3633-3642
    • de Belle, I.1    Huang, R.P.2    Fan, Y.3    Liu, C.4    Mercola, D.5
  • 17
    • 0034617216 scopus 로고    scopus 로고
    • The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251
    • Liu C, Yao J, Mercola D, Adamson E (2000) The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251. J Biol Chem 275: 20315-20323.
    • (2000) J Biol Chem , vol.275 , pp. 20315-20323
    • Liu, C.1    Yao, J.2    Mercola, D.3    Adamson, E.4
  • 18
    • 0028559569 scopus 로고
    • Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene
    • Shingu T, Bornstein P (1994) Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene. J Biol Chem 269: 32551-32557.
    • (1994) J Biol Chem , vol.269 , pp. 32551-32557
    • Shingu, T.1    Bornstein, P.2
  • 19
    • 0041737535 scopus 로고    scopus 로고
    • Molecular mechanisms of glioma invasiveness: The role of proteases
    • Rao JS (2003) Molecular mechanisms of glioma invasiveness: the role of proteases. Nat Rev Cancer 3: 489-501.
    • (2003) Nat Rev Cancer , vol.3 , pp. 489-501
    • Rao, J.S.1
  • 22
    • 28244477646 scopus 로고    scopus 로고
    • Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at Rizzoli Institute, Italy
    • Bacci G, Longhi A, Fagioli F, Briccoli A, Versari M, et al. (2005) Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at Rizzoli Institute, Italy. Eur J Cancer 41: 2836-2845.
    • (2005) Eur J Cancer , vol.41 , pp. 2836-2845
    • Bacci, G.1    Longhi, A.2    Fagioli, F.3    Briccoli, A.4    Versari, M.5
  • 23
    • 66149135224 scopus 로고    scopus 로고
    • International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons
    • Mirabello L, Troisi RJ, Savage SA (2009) International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons. Int J Cancer 125: 229-234.
    • (2009) Int J Cancer , vol.125 , pp. 229-234
    • Mirabello, L.1    Troisi, R.J.2    Savage, S.A.3
  • 25
    • 31544466778 scopus 로고    scopus 로고
    • Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10
    • Kim J, Lee YH, Kwon TK, Chang JS, Chung KC, et al. (2006) Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10. Cancer Res 66: 784-793.
    • (2006) Cancer Res , vol.66 , pp. 784-793
    • Kim, J.1    Lee, Y.H.2    Kwon, T.K.3    Chang, J.S.4    Chung, K.C.5
  • 26
    • 30944446390 scopus 로고    scopus 로고
    • The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin
    • Baron V, Adamson ED, Calogero A, Ragona G, Mercola D (2006) The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther 13: 115-124.
    • (2006) Cancer Gene Ther , vol.13 , pp. 115-124
    • Baron, V.1    Adamson, E.D.2    Calogero, A.3    Ragona, G.4    Mercola, D.5
  • 27
    • 76949102583 scopus 로고    scopus 로고
    • Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells
    • Mahalingam D, Natoni A, Keane M, Samali A, Szegezdi E (2010) Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells. Br J Cancer 102: 754-764.
    • (2010) Br J Cancer , vol.102 , pp. 754-764
    • Mahalingam, D.1    Natoni, A.2    Keane, M.3    Samali, A.4    Szegezdi, E.5
  • 28
    • 23844529722 scopus 로고    scopus 로고
    • Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1
    • Chen CC, Lee WR, Safe S (2004) Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1. J Cell Biochem 93: 1063-1074.
    • (2004) J Cell Biochem , vol.93 , pp. 1063-1074
    • Chen, C.C.1    Lee, W.R.2    Safe, S.3
  • 29
    • 0344406281 scopus 로고    scopus 로고
    • The egr-1 gene is induced by DNA-damaging agents and non-genotoxic drugs in both normal and neoplastic human cells
    • Quinones A, Dobberstein KU, Rainov NG (2003) The egr-1 gene is induced by DNA-damaging agents and non-genotoxic drugs in both normal and neoplastic human cells. Life Sci 72: 2975-2992.
    • (2003) Life Sci , vol.72 , pp. 2975-2992
    • Quinones, A.1    Dobberstein, K.U.2    Rainov, N.G.3
  • 30
    • 65249135564 scopus 로고    scopus 로고
    • Transforming growth factor beta1- mediated activation of the smooth muscle alpha-actin gene in human pulmonary myofibroblasts is inhibited by tumor necrosis factor-alpha via mitogen-activated protein kinase kinase 1-dependent induction of the Egr-1 transcriptional repressor
    • Liu X, Kelm RJ Jr., Strauch AR (2009) Transforming growth factor beta1- mediated activation of the smooth muscle alpha-actin gene in human pulmonary myofibroblasts is inhibited by tumor necrosis factor-alpha via mitogen-activated protein kinase kinase 1-dependent induction of the Egr-1 transcriptional repressor. Mol Biol Cell 20: 2174-2185.
    • (2009) Mol Biol Cell , vol.20 , pp. 2174-2185
    • Liu, X.1    Kelm Jr., R.J.2    Strauch, A.R.3
  • 31
    • 0032482367 scopus 로고    scopus 로고
    • Stress-induced immediate-early gene, egr-1, involves activation of p38/JNK1
    • Lim CP, Jain N, Cao X (1998) Stress-induced immediate-early gene, egr-1, involves activation of p38/JNK1. Oncogene 16: 2915-2926.
    • (1998) Oncogene , vol.16 , pp. 2915-2926
    • Lim, C.P.1    Jain, N.2    Cao, X.3
  • 32
    • 0032996518 scopus 로고    scopus 로고
    • Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2
    • Santiago FS, Lowe HC, Day FL, Chesterman CN, Khachigian LM (1999) Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2. Am J Pathol 154: 937-944.
    • (1999) Am J Pathol , vol.154 , pp. 937-944
    • Santiago, F.S.1    Lowe, H.C.2    Day, F.L.3    Chesterman, C.N.4    Khachigian, L.M.5
  • 33
    • 0032102209 scopus 로고    scopus 로고
    • Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway
    • Schwachtgen JL, Houston P, Campbell C, Sukhatme V, Braddock M (1998) Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway. J Clin Invest 101: 2540-2549.
    • (1998) J Clin Invest , vol.101 , pp. 2540-2549
    • Schwachtgen, J.L.1    Houston, P.2    Campbell, C.3    Sukhatme, V.4    Braddock, M.5
  • 34
    • 33746215094 scopus 로고    scopus 로고
    • Induction of the early growth response 1 gene by Epstein-Barr virus lytic transactivator Zta
    • Chang Y, Lee HH, Chen YT, Lu J, Wu SY, et al. (2006) Induction of the early growth response 1 gene by Epstein-Barr virus lytic transactivator Zta. J Virol 80: 7748-7755.
    • (2006) J Virol , vol.80 , pp. 7748-7755
    • Chang, Y.1    Lee, H.H.2    Chen, Y.T.3    Lu, J.4    Wu, S.Y.5
  • 35
    • 77955177292 scopus 로고    scopus 로고
    • EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor
    • Su L, Cheng H, Sampaio AV, Nielsen TO, Underhill TM (2010) EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor. Oncogene 29: 4352-4361.
    • (2010) Oncogene , vol.29 , pp. 4352-4361
    • Su, L.1    Cheng, H.2    Sampaio, A.V.3    Nielsen, T.O.4    Underhill, T.M.5
  • 36
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman MM, Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427.
    • (1993) Annu Rev Biochem , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 37
    • 0030806906 scopus 로고    scopus 로고
    • Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents
    • Ihnat MA, Lariviere JP, Warren AJ, La Ronde N, Blaxall JR, et al. (1997) Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents. Clin Cancer Res 3: 1339-1346.
    • (1997) Clin Cancer Res , vol.3 , pp. 1339-1346
    • Ihnat, M.A.1    Lariviere, J.P.2    Warren, A.J.3    La Ronde, N.4    Blaxall, J.R.5
  • 39
    • 53249122047 scopus 로고    scopus 로고
    • Urokinase plasminogen activator receptor choreographs multiple ligand interactions: Implications for tumor progression and therapy
    • Mazar AP (2008) Urokinase plasminogen activator receptor choreographs multiple ligand interactions: implications for tumor progression and therapy. Clin Cancer Res 14: 5649-5655.
    • (2008) Clin Cancer Res , vol.14 , pp. 5649-5655
    • Mazar, A.P.1
  • 40
    • 0027202040 scopus 로고
    • Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line
    • Kariko K, Kuo A, Boyd D, Okada SS, Cines DB, et al. (1993) Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line. Cancer Res 53: 3109-3117.
    • (1993) Cancer Res , vol.53 , pp. 3109-3117
    • Kariko, K.1    Kuo, A.2    Boyd, D.3    Okada, S.S.4    Cines, D.B.5
  • 41
    • 0041736272 scopus 로고    scopus 로고
    • C-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells
    • MacEwen EG, Kutzke J, Carew J, Pastor J, Schmidt JA, et al. (2003) c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells. Clin Exp Metastasis 20: 421-430.
    • (2003) Clin Exp Metastasis , vol.20 , pp. 421-430
    • McEwen, E.G.1    Kutzke, J.2    Carew, J.3    Pastor, J.4    Schmidt, J.A.5
  • 42
    • 5444242379 scopus 로고    scopus 로고
    • IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma
    • MacEwen EG, Pastor J, Kutzke J, Tsan R, Kurzman ID, et al. (2004) IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. J Cell Biochem 92: 77-91.
    • (2004) J Cell Biochem , vol.92 , pp. 77-91
    • McEwen, E.G.1    Pastor, J.2    Kutzke, J.3    Tsan, R.4    Kurzman, I.D.5
  • 43
    • 22544451538 scopus 로고    scopus 로고
    • Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells
    • de Bock CE, Lin Z, Itoh T, Morris D, Murrell G, et al. (2005) Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells. Febs J 272: 3572-3582.
    • (2005) Febs J , vol.272 , pp. 3572-3582
    • de Bock, C.E.1    Lin, Z.2    Itoh, T.3    Morris, D.4    Murrell, G.5
  • 46
    • 0029809873 scopus 로고    scopus 로고
    • Requirement of an upstream AP-1 motif for the constitutive and phorbol ester-inducible expression of the urokinase-type plasminogen activator receptor gene
    • Lengyel E, Wang H, Stepp E, Juarez J, Wang Y, et al. (1996) Requirement of an upstream AP-1 motif for the constitutive and phorbol ester-inducible expression of the urokinase-type plasminogen activator receptor gene. J Biol Chem 271: 23176-23184.
    • (1996) J Biol Chem , vol.271 , pp. 23176-23184
    • Lengyel, E.1    Wang, H.2    Stepp, E.3    Juarez, J.4    Wang, Y.5
  • 47
    • 0037374289 scopus 로고    scopus 로고
    • Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1
    • Krishnamachary B, Berg-Dixon S, Kelly B, Agani F, Feldser D, et al. (2003) Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res 63: 1138-1143.
    • (2003) Cancer Res , vol.63 , pp. 1138-1143
    • Krishnamachary, B.1    Berg-Dixon, S.2    Kelly, B.3    Agani, F.4    Feldser, D.5
  • 48
    • 44849100198 scopus 로고    scopus 로고
    • NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
    • Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, et al. (2008) NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 453: 807-811.
    • (2008) Nature , vol.453 , pp. 807-811
    • Rius, J.1    Guma, M.2    Schachtrup, C.3    Akassoglou, K.4    Zinkernagel, A.S.5
  • 49
    • 70450196419 scopus 로고    scopus 로고
    • Targeting sarcomas: Novel biological agents and future perspectives
    • Mahalingam D, Mita A, Sankhala K, Swords R, Kelly K, et al. (2009) Targeting sarcomas: novel biological agents and future perspectives. Curr Drug Targets 10: 937-949.
    • (2009) Curr Drug Targets , vol.10 , pp. 937-949
    • Mahalingam, D.1    Mita, A.2    Sankhala, K.3    Swords, R.4    Kelly, K.5
  • 50
    • 48349107149 scopus 로고    scopus 로고
    • Tumour-targeted nanomedicines: Principles and practice
    • Lammers T, Hennink WE, Storm G (2008) Tumour-targeted nanomedicines: principles and practice. Br J Cancer 99: 392-397.
    • (2008) Br J Cancer , vol.99 , pp. 392-397
    • Lammers, T.1    Hennink, W.E.2    Storm, G.3
  • 51
    • 75149130051 scopus 로고    scopus 로고
    • Targeting the cancer kinome through polypharmacology
    • Knight ZA, Lin H, Shokat KM (2010) Targeting the cancer kinome through polypharmacology. Nat Rev Cancer 10: 130-137.
    • (2010) Nat Rev Cancer , vol.10 , pp. 130-137
    • Knight, Z.A.1    Lin, H.2    Shokat, K.M.3
  • 52
    • 57749188299 scopus 로고    scopus 로고
    • Targeting cancer with small molecule kinase inhibitors
    • Zhang J, Yang PL, Gray NS (2009) Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 9: 28-39.
    • (2009) Nat Rev Cancer , vol.9 , pp. 28-39
    • Zhang, J.1    Yang, P.L.2    Gray, N.S.3
  • 53
    • 67650407720 scopus 로고    scopus 로고
    • Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease
    • Henley DB, May PC, Dean RA, Siemers ER (2009) Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease. Expert Opin Pharmacother 10: 1657-1664.
    • (2009) Expert Opin Pharmacother , vol.10 , pp. 1657-1664
    • Henley, D.B.1    May, P.C.2    Dean, R.A.3    Siemers, E.R.4
  • 54
    • 66749084437 scopus 로고    scopus 로고
    • A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system
    • Bateman RJ, Siemers ER, Mawuenyega KG, Wen G, Browning KR, et al. (2009) A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system. Ann Neurol 66: 48-54.
    • (2009) Ann Neurol , vol.66 , pp. 48-54
    • Bateman, R.J.1    Siemers, E.R.2    Mawuenyega, K.G.3    Wen, G.4    Browning, K.R.5
  • 55
    • 49449101906 scopus 로고    scopus 로고
    • Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease
    • Fleisher AS, Raman R, Siemers ER, Becerra L, Clark CM, et al. (2008) Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease. Arch Neurol 65: 1031-1038.
    • (2008) Arch Neurol , vol.65 , pp. 1031-1038
    • Fleisher, A.S.1    Raman, R.2    Siemers, E.R.3    Becerra, L.4    Clark, C.M.5
  • 56
    • 67349182923 scopus 로고    scopus 로고
    • Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation
    • Tanaka M, Setoguchi T, Hirotsu M, Gao H, Sasaki H, et al. (2009) Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. Br J Cancer 100: 1957-1965.
    • (2009) Br J Cancer , vol.100 , pp. 1957-1965
    • Tanaka, M.1    Setoguchi, T.2    Hirotsu, M.3    Gao, H.4    Sasaki, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.