메뉴 건너뛰기




Volumn 48, Issue SUPPL. 1, 2010, Pages

Thrombophilia screening - At the right time, for the right patient, with a good reason

Author keywords

Pregnancy complications; screening; thromboembolism; thrombophilia

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 5 LEIDEN; ORAL CONTRACEPTIVE AGENT; PHOSPHOLIPID ANTIBODY; PROTEIN C; PROTEIN S; PROTHROMBIN; WARFARIN;

EID: 79251621020     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2010.367     Document Type: Review
Times cited : (15)

References (66)
  • 2
    • 0034870502 scopus 로고    scopus 로고
    • Laboratory investigation of thrombophilia
    • Tripodi A, Mannucci PM. Laboratory investigation of thrombophilia. Clin Chem 2001;47:1597-606.
    • (2001) Clin Chem , vol.47 , pp. 1597-1606
    • Tripodi, A.1    Mannucci, P.M.2
  • 3
    • 33645046565 scopus 로고    scopus 로고
    • Thrombophilia and venous thromboembolism. International consensus statement. Guidelines according to scientific evidence
    • Nicolaides AN, Breddin HK, Carpenter P, Coccheri S, Conard J, De Stefano V, et al. Thrombophilia and venous thromboembolism. International consensus statement. Guidelines according to scientific evidence. Int Angiol 2005;24:1-26.
    • (2005) Int Angiol , vol.24 , pp. 1-26
    • Nicolaides, A.N.1    Breddin, H.K.2    Carpenter, P.3    Coccheri, S.4    Conard, J.5    De Stefano, V.6
  • 4
    • 67849104652 scopus 로고    scopus 로고
    • Genetics of venous thrombosis
    • Rosendaal FR, Reitsma PH. Genetics of venous thrombosis. J Thromb Haemost 2009;7(Suppl 1):301-4.
    • (2009) J Thromb Haemost , vol.7 , Issue.SUPPL. 1 , pp. 301-304
    • Rosendaal, F.R.1    Reitsma, P.H.2
  • 5
    • 0642372646 scopus 로고    scopus 로고
    • Pros and cons of thrombophilia testing: Cons
    • Machin SJ. Pros and cons of thrombophilia testing: Cons. J Thromb Haemost 2003;1:412-3.
    • (2003) J Thromb Haemost , vol.1 , pp. 412-413
    • Machin, S.J.1
  • 6
    • 0037443934 scopus 로고    scopus 로고
    • Thrombophilic disorders and fetal loss: A meta-analysis
    • Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: A meta-analysis. Lancet 2003;361:901-8.
    • (2003) Lancet , vol.361 , pp. 901-908
    • Rey, E.1    Kahn, S.R.2    David, M.3    Shrier, I.4
  • 7
    • 34250706405 scopus 로고    scopus 로고
    • Thrombophilia and pregnancy complications: Cause or association?
    • Middeldorp S. Thrombophilia and pregnancy complications: Cause or association? J Thromb Haemost 2007;5(Suppl 1): 276-82.
    • (2007) J Thromb Haemost , vol.5 , Issue.SUPPL. 1 , pp. 276-282
    • Middeldorp, S.1
  • 8
    • 0028008663 scopus 로고
    • Venous thromboembolic complications (VTE) in children: First analyses of the Canadian Registry of VTE
    • Andrew M, David M, Adams M, Ali K, Anderson R, Barnard D, et al. Venous thromboembolic complications (VTE) in children: First analyses of the Canadian Registry of VTE. Blood 1994;83:1251-7.
    • (1994) Blood , vol.83 , pp. 1251-1257
    • Andrew, M.1    David, M.2    Adams, M.3    Ali, K.4    Anderson, R.5    Barnard, D.6
  • 11
    • 67651151593 scopus 로고    scopus 로고
    • Thrombophilia in children: Who to test how when and why?
    • Raffini L. Thrombophilia in children: Who to test, how, when, and why? Hematology Am Soc Hematol Educ Program 2008: 228-35.
    • (2008) Hematology Am Soc Hematol Educ Program , pp. 228-235
    • Raffini, L.1
  • 12
    • 0026640902 scopus 로고
    • Warfarin-induced skin necrosis in 2 patients with protein S deficiency: Successful reinstatement of warfarin therapy
    • Anderson DR, Brill-Edwards P, Walker I. Warfarin-induced skin necrosis in 2 patients with protein S deficiency: Successful reinstatement of warfarin therapy. Haemostasis 1992;22:124-8.
    • (1992) Haemostasis , vol.22 , pp. 124-128
    • Anderson, D.R.1    Brill-Edwards, P.2    Walker, I.3
  • 14
    • 48549098855 scopus 로고    scopus 로고
    • Thrombophilia: Common questions on laboratory assessment and management
    • Heit JA. Thrombophilia: Common questions on laboratory assessment and management. Hematology Am Soc Hematol Educ Program 2007:127-35.
    • (2007) Hematology Am Soc Hematol Educ Program , pp. 127-135
    • Heit, J.A.1
  • 15
    • 0027520285 scopus 로고
    • Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden thrombophilia study
    • Koster T, Rosendaal FR, de Ronde H, Briet E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993;342:1503-6.
    • (1993) Lancet , vol.342 , pp. 1503-1506
    • Koster, T.1    Rosendaal, F.R.2    De Ronde, H.3    Briet, E.4    Vandenbroucke, J.P.5    Bertina, R.M.6
  • 16
    • 0029850530 scopus 로고    scopus 로고
    • A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
    • Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996;88: 3698-703.
    • (1996) Blood , vol.88 , pp. 3698-3703
    • Poort, S.R.1    Rosendaal, F.R.2    Reitsma, P.H.3    Bertina, R.M.4
  • 18
    • 0028029477 scopus 로고
    • Increased risk of venous thrombosis in oralcontraceptive users who are carriers of Factor V Leiden mutation
    • Vandenbroucke JP, Koster T, Briet E, Reitsma PH, Bertina RM, Rosendaal FR. Increased risk of venous thrombosis in oralcontraceptive users who are carriers of Factor V Leiden mutation. Lancet 1994;344:1453-7.
    • (1994) Lancet , vol.344 , pp. 1453-1457
    • Vandenbroucke, J.P.1    Koster, T.2    Briet, E.3    Reitsma, P.H.4    Bertina, R.M.5    Rosendaal, F.R.6
  • 19
    • 0032976317 scopus 로고    scopus 로고
    • Interaction between the G20210A mutation of the prothrombin gene and oral contraceptive use in deep vein thrombosis
    • Martinelli I, Taioli E, Bucciarelli P, Akhavan S, Mannucci PM. Interaction between the G20210A mutation of the prothrombin gene and oral contraceptive use in deep vein thrombosis. Arterioscler Thromb Vasc Biol 1999;19:700-3.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 700-703
    • Martinelli, I.1    Taioli, E.2    Bucciarelli, P.3    Akhavan, S.4    Mannucci, P.M.5
  • 22
    • 0032741802 scopus 로고    scopus 로고
    • Risk factors for venous thrombotic disease
    • Rosendaal FR. Risk factors for venous thrombotic disease. Thromb Haemost 1999;82:610-9.
    • (1999) Thromb Haemost , vol.82 , pp. 610-619
    • Rosendaal, F.R.1
  • 24
    • 40349091368 scopus 로고    scopus 로고
    • Evidence-based indications for thrombophilia screening
    • Lindhoff-Last E, Luxembourg B. Evidence-based indications for thrombophilia screening. Vasa 2008;37:19-30.
    • (2008) Vasa , vol.37 , pp. 19-30
    • Lindhoff-Last, E.1    Luxembourg, B.2
  • 25
    • 77949447984 scopus 로고    scopus 로고
    • Prevention of venous thromboembolism: Consensus, controversies, and challenges
    • Selby R, Geerts W. Prevention of venous thromboembolism: Consensus, controversies, and challenges. Hematology Am Soc Hematol Educ Program 2009:286-92.
    • (2009) Hematology Am Soc Hematol Educ Program , pp. 286-292
    • Selby, R.1    Geerts, W.2
  • 26
    • 0030984288 scopus 로고    scopus 로고
    • Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women
    • Rosendaal FR, Siscovick DS, Schwartz SM, Beverly RK, Psaty BM, Longstreth WT Jr, et al. Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women. Blood 1997;89:2817-21.
    • (1997) Blood , vol.89 , pp. 2817-2821
    • Rosendaal, F.R.1    Siscovick, D.S.2    Schwartz, S.M.3    Beverly, R.K.4    Psaty, B.M.5    Longstreth Jr., W.T.6
  • 28
    • 0032525101 scopus 로고    scopus 로고
    • Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients
    • De Stefano V, Chiusolo P, Paciaroni K, Casorelli I, Rossi E, Molinari M, et al. Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients. Blood 1998;91:3562-5.
    • (1998) Blood , vol.91 , pp. 3562-3565
    • De Stefano, V.1    Chiusolo, P.2    Paciaroni, K.3    Casorelli, I.4    Rossi, E.5    Molinari, M.6
  • 29
    • 0028910906 scopus 로고
    • Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men
    • Ridker PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 1995;332:912-7.
    • (1995) N Engl J Med , vol.332 , pp. 912-917
    • Ridker, P.M.1    Hennekens, C.H.2    Lindpaintner, K.3    Stampfer, M.J.4    Eisenberg, P.R.5    Miletich, J.P.6
  • 30
    • 13844254899 scopus 로고    scopus 로고
    • High prevalence of thrombophilia among young patients with myocardial infarction and few conventional risk factors
    • Segev A, Ellis MH, Segev F, Friedman Z, Reshef T, Sparkes JD, et al. High prevalence of thrombophilia among young patients with myocardial infarction and few conventional risk factors. Int J Cardiol 2005;98:421-4.
    • (2005) Int J Cardiol , vol.98 , pp. 421-424
    • Segev, A.1    Ellis, M.H.2    Segev, F.3    Friedman, Z.4    Reshef, T.5    Sparkes, J.D.6
  • 33
    • 0027407356 scopus 로고
    • An antithrombin III assay based on factor Xa inhibition provides a more reliable test to identify congenital antithrombin III deficiency than an assay based on thrombin inhibition
    • Demers C, Henderson P, Blajchman MA, Wells MJ, Mitchell L, Johnston M, et al. An antithrombin III assay based on factor Xa inhibition provides a more reliable test to identify congenital antithrombin III deficiency than an assay based on thrombin inhibition. Thromb Haemost 1993;69:231-5.
    • (1993) Thromb Haemost , vol.69 , pp. 231-235
    • Demers, C.1    Henderson, P.2    Blajchman, M.A.3    Wells, M.J.4    Mitchell, L.5    Johnston, M.6
  • 34
    • 55949104988 scopus 로고    scopus 로고
    • Inherited antithrombin deficiency: A review
    • Patnaik MM, Moll S. Inherited antithrombin deficiency: A review. Haemophilia 2008;14:1229-39.
    • (2008) Haemophilia , vol.14 , pp. 1229-1239
    • Patnaik, M.M.1    Moll, S.2
  • 35
    • 0037085777 scopus 로고    scopus 로고
    • Discrepancy between antithrombin activity methods revealed in Antithrombin Stockholm: Do factor Xa-based methods overestimate antithrombin activity in some patients?
    • Ungerstedt JS, Schulman S, Egberg N, Antovic J, Blomback N. Discrepancy between antithrombin activity methods revealed in Antithrombin Stockholm: Do factor Xa-based methods overestimate antithrombin activity in some patients? Blood 2002;99:2271-2.
    • (2002) Blood , vol.99 , pp. 2271-2272
    • Ungerstedt, J.S.1    Schulman, S.2    Egberg, N.3    Antovic, J.4    Blomback, N.5
  • 36
    • 0029895068 scopus 로고    scopus 로고
    • Resistance to activated protein C mimicking dysfunctional protein C: Diagnostic approach
    • Faioni EM, Franchi F, Asti D, Mannucci PM. Resistance to activated protein C mimicking dysfunctional protein C: Diagnostic approach. Blood Coagul Fibrinolysis 1996;7:349-52.
    • (1996) Blood Coagul Fibrinolysis , vol.7 , pp. 349-352
    • Faioni, E.M.1    Franchi, F.2    Asti, D.3    Mannucci, P.M.4
  • 37
    • 18844467682 scopus 로고
    • Spuriously low levels of protein C with a Protac activation clotting assay
    • de Moerloose P, Reber G, Bouvier CA. Spuriously low levels of protein C with a Protac activation clotting assay. Thromb Haemost 1988;59:543.
    • (1988) Thromb Haemost , vol.59 , pp. 543
    • De Moerloose, P.1    Reber, G.2    Bouvier, C.A.3
  • 39
    • 0027742936 scopus 로고
    • Resistance to activated protein C in nine thrombophilic families: Interference in a protein S functional assay
    • Faioni EM, Franchi F, Asti D, Sacchi E, Bernardi F, Mannucci PM. Resistance to activated protein C in nine thrombophilic families: Interference in a protein S functional assay. Thromb Haemost 1993;70:1067-71.
    • (1993) Thromb Haemost , vol.70 , pp. 1067-1071
    • Faioni, E.M.1    Franchi, F.2    Asti, D.3    Sacchi, E.4    Bernardi, F.5    Mannucci, P.M.6
  • 40
    • 0031964419 scopus 로고    scopus 로고
    • Clarification of the risk for venous thrombosis associated with hereditary protein S deficiency by investigation of a large kindred with a characterized gene defect
    • Simmonds RE, Ireland H, Lane DA, Zoller B, Garcia de Frutos P, Dahlback B. Clarification of the risk for venous thrombosis associated with hereditary protein S deficiency by investigation of a large kindred with a characterized gene defect. Ann Intern Med 1998;128:8-14.
    • (1998) Ann Intern Med , vol.128 , pp. 8-14
    • Simmonds, R.E.1    Ireland, H.2    Lane, D.A.3    Zoller, B.4    Garcia De Frutos, P.5    Dahlback, B.6
  • 41
    • 0027446268 scopus 로고
    • Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C
    • Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993;90:1004-8.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1004-1008
    • Dahlback, B.1    Carlsson, M.2    Svensson, P.J.3
  • 42
    • 1842416567 scopus 로고    scopus 로고
    • Evaluation of original and modified APC-resistance tests in unselected outpatients with clinically suspected thrombosis and in healthy controls
    • Svensson PJ, Zoller B, Dahlback B. Evaluation of original and modified APC-resistance tests in unselected outpatients with clinically suspected thrombosis and in healthy controls. Thromb Haemost 1997;77:332-5.
    • (1997) Thromb Haemost , vol.77 , pp. 332-335
    • Svensson, P.J.1    Zoller, B.2    Dahlback, B.3
  • 44
    • 77950428407 scopus 로고    scopus 로고
    • Analytic validity of genetic tests to identify Factor V Leiden and prothrombin G20210A
    • Emadi A, Crim MT, Brotman DJ, Necochea AJ, Samal L, Wilson LM, et al. Analytic validity of genetic tests to identify Factor V Leiden and prothrombin G20210A. Am J Hematol 2010;85:264-70.
    • (2010) Am J Hematol , vol.85 , pp. 264-270
    • Emadi, A.1    Crim, M.T.2    Brotman, D.J.3    Necochea, A.J.4    Samal, L.5    Wilson, L.M.6
  • 45
    • 0028037137 scopus 로고
    • Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C
    • Zoller B, Svensson PJ, He X, Dahlback B. Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. J Clin Invest 1994;94:2521-4.
    • (1994) J Clin Invest , vol.94 , pp. 2521-2524
    • Zoller, B.1    Svensson, P.J.2    He, X.3    Dahlback, B.4
  • 47
    • 70350004861 scopus 로고    scopus 로고
    • Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis
    • Pengo V, Tripodi A, Reber G, Rand JH, Ortel TL, Galli M, et al. Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. J Thromb Haemost 2009;7:1737-40.
    • (2009) J Thromb Haemost , vol.7 , pp. 1737-1740
    • Pengo, V.1    Tripodi, A.2    Reber, G.3    Rand, J.H.4    Ortel, T.L.5    Galli, M.6
  • 48
    • 39549099464 scopus 로고    scopus 로고
    • Current insight into diagnostics and pathophysiology of the antiphospholipid syndrome
    • Urbanus RT, Derksen RH, de Groot PG. Current insight into diagnostics and pathophysiology of the antiphospholipid syndrome. Blood Rev 2008;22:93-105.
    • (2008) Blood Rev , vol.22 , pp. 93-105
    • Urbanus, R.T.1    Derksen, R.H.2    De Groot, P.G.3
  • 49
    • 0141727646 scopus 로고    scopus 로고
    • Lupus anticoagulant (LA) testing: Performance of clinical laboratories assessed by a national survey using lyophilized affinity-purified immunoglobulin with LA activity
    • Tripodi A, Biasiolo A, Chantarangkul V, Pengo V. Lupus anticoagulant (LA) testing: Performance of clinical laboratories assessed by a national survey using lyophilized affinity-purified immunoglobulin with LA activity. Clin Chem 2003;49: 1608-14.
    • (2003) Clin Chem , vol.49 , pp. 1608-1614
    • Tripodi, A.1    Biasiolo, A.2    Chantarangkul, V.3    Pengo, V.4
  • 50
    • 34247894036 scopus 로고    scopus 로고
    • Survey of lupus anticoagulant diagnosis by central evaluation of positive plasma samples
    • Pengo V, Biasiolo A, Gresele P, Marongiu F, Erba N, Veschi F, et al. Survey of lupus anticoagulant diagnosis by central evaluation of positive plasma samples. J Thromb Haemost 2007;5: 925-30.
    • (2007) J Thromb Haemost , vol.5 , pp. 925-930
    • Pengo, V.1    Biasiolo, A.2    Gresele, P.3    Marongiu, F.4    Erba, N.5    Veschi, F.6
  • 51
    • 54049096018 scopus 로고    scopus 로고
    • Does thrombophilia testing help in the clinical management of patients?
    • Middeldorp S, van Hylckama Vlieg A. Does thrombophilia testing help in the clinical management of patients? Br J Haematol 2008;143:321-35.
    • (2008) Br J Haematol , vol.143 , pp. 321-335
    • Middeldorp, S.1    Van Hylckama Vlieg, A.2
  • 53
    • 33744467056 scopus 로고    scopus 로고
    • The risk of recurrent venous thromboembolism in patients with inherited deficiency of natural anticoagulants antithrombin, protein C and protein S
    • De Stefano V, Simioni P, Rossi E, Tormene D, Za T, Pagnan A, et al. The risk of recurrent venous thromboembolism in patients with inherited deficiency of natural anticoagulants antithrombin, protein C and protein S. Haematologica 2006;91: 695-8.
    • (2006) Haematologica , vol.91 , pp. 695-698
    • De Stefano, V.1    Simioni, P.2    Rossi, E.3    Tormene, D.4    Za, T.5    Pagnan, A.6
  • 54
    • 0042658340 scopus 로고    scopus 로고
    • Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: Prospective cohort study
    • Baglin T, Luddington R, Brown K, Baglin C. Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: Prospective cohort study. Lancet 2003;362:523-6.
    • (2003) Lancet , vol.362 , pp. 523-526
    • Baglin, T.1    Luddington, R.2    Brown, K.3    Baglin, C.4
  • 55
    • 0033710040 scopus 로고    scopus 로고
    • Extended anticoagulation for prevention of recurrent venous thromboembolism in carriers of Factor V Leiden - Cost-effectiveness analysis
    • Marchetti M, Pistorio A, Barosi G. Extended anticoagulation for prevention of recurrent venous thromboembolism in carriers of Factor V Leiden - cost-effectiveness analysis. Thromb Haemost 2000;84:752-7.
    • (2000) Thromb Haemost , vol.84 , pp. 752-757
    • Marchetti, M.1    Pistorio, A.2    Barosi, G.3
  • 56
    • 0033709868 scopus 로고    scopus 로고
    • Duration of oral anticoagulant treatment in patients with venous thromboembolism and a deficiency of antithrombin, protein C or protein S - A decision analysis
    • van den Belt AG, Hutten BA, Prins MH, Bossuy PM. Duration of oral anticoagulant treatment in patients with venous thromboembolism and a deficiency of antithrombin, protein C or protein S - a decision analysis. Thromb Haemost 2000;84:758-63.
    • (2000) Thromb Haemost , vol.84 , pp. 758-763
    • Van Den Belt, A.G.1    Hutten, B.A.2    Prins, M.H.3    Bossuy, P.M.4
  • 57
    • 34548315929 scopus 로고    scopus 로고
    • Laboratory testing for lupus anticoagulants: A review of issues affecting results
    • Tripodi A. Laboratory testing for lupus anticoagulants: A review of issues affecting results. Clin Chem 2007;53:1629-35.
    • (2007) Clin Chem , vol.53 , pp. 1629-1635
    • Tripodi, A.1
  • 59
    • 0030015821 scopus 로고    scopus 로고
    • Assessment of a bleeding risk index in two cohorts of patients treated with oral anticoagulants
    • van der Meer FJ, Rosendaal FR, Vandenbroucke JP, Briet E. Assessment of a bleeding risk index in two cohorts of patients treated with oral anticoagulants. Thromb Haemost 1996;76: 12-6.
    • (1996) Thromb Haemost , vol.76 , pp. 12-16
    • Van Der Meer, F.J.1    Rosendaal, F.R.2    Vandenbroucke, J.P.3    Briet, E.4
  • 60
    • 45949094478 scopus 로고    scopus 로고
    • Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy
    • American College of Chest Physicians Evidence- Based Clinical Practice Guidelines (8th edition)
    • Bates SM, Greer IA, Pabinger I, Sofaer S, Hirsh J. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence- Based Clinical Practice Guidelines (8th edition). Chest 2008; 133:844S-86S.
    • (2008) Chest , vol.133
    • Bates, S.M.1    Greer, I.A.2    Pabinger, I.3    Sofaer, S.4    Hirsh, J.5
  • 61
    • 0037253814 scopus 로고    scopus 로고
    • Guidelines for the laboratory investigation of inherited thrombophilias. Recommendations for the first level clinical laboratories
    • Carraro P. Guidelines for the laboratory investigation of inherited thrombophilias. Recommendations for the first level clinical laboratories. Clin Chem Lab Med 2003;41:382-91.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 382-391
    • Carraro, P.1
  • 62
    • 37249037439 scopus 로고    scopus 로고
    • Molecular screening for familial hypercholesterolaemia: Consequences for life and disability insurance
    • Homsma SJ, Huijgen R, Middeldorp S, Sijbrands EJ, Kastelein JJ. Molecular screening for familial hypercholesterolaemia: Consequences for life and disability insurance. Eur J Hum Genet 2008;16:14-7.
    • (2008) Eur J Hum Genet , vol.16 , pp. 14-17
    • Homsma, S.J.1    Huijgen, R.2    Middeldorp, S.3    Sijbrands, E.J.4    Kastelein, J.J.5
  • 63
    • 0037387855 scopus 로고    scopus 로고
    • Genetic exceptionalism in medicine: Clarifying the differences between genetic and nongenetic tests
    • Green MJ, Botkin JR. ''Genetic exceptionalism'' in medicine: Clarifying the differences between genetic and nongenetic tests. Ann Intern Med 2003;138:571-5.
    • (2003) Ann Intern Med , vol.138 , pp. 571-575
    • Green, M.J.1    Botkin, J.R.2
  • 65
    • 3543112175 scopus 로고    scopus 로고
    • Short- and long-term impact of receiving genetic mutation results in women at increased risk for hereditary breast cancer
    • Lim J, Macluran M, Price M, Bennett B, Butow P. Short- and long-term impact of receiving genetic mutation results in women at increased risk for hereditary breast cancer. J Genet Couns 2004;13:115-33.
    • (2004) J Genet Couns , vol.13 , pp. 115-133
    • Lim, J.1    Macluran, M.2    Price, M.3    Bennett, B.4    Butow, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.