Construction of kanamycin B overproducing strain by genetic engineering of Streptomyces tenebrarius

Applied Microbiology and Biotechnology

Volumn 89, Issue 3, 2011, Pages 723-731

  Ni, Xianpu ^a   Li, Dan ^a   Yang, Lihua ^a   Huang, Tingjiao ^a   Li, Hao ^a   Xia, Huanzhang ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Carbamoyl transfer gene; Deoxygenation; Gene disruption; Kanamycin B; Strain improvement; Streptomyces tenebrarius

Indexed keywords

DEOXYGENATIONS; GENE DISRUPTION; KANAMYCINS; STRAIN IMPROVEMENT; STREPTOMYCES TENEBRARIUS; TRANSFER GENES;

ANTIBIOTICS; BIOCHEMISTRY; BIOSYNTHESIS; GENETIC ENGINEERING; OPTIMIZATION;

GENES;

APRAMYCIN; DIBEKACIN; HABEKACIN; KANAMYCIN B; TOBRAMYCIN;

ANTIBIOTICS; BACTERIUM; GENETIC ANALYSIS; GENETIC ENGINEERING; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MUTATION; OXYGENATION;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BIOSYNTHESIS; CONTROLLED STUDY; DEOXYGENATION; DRUG HYDROLYSIS; DRUG SYNTHESIS; GENE CLUSTER; GENE DISRUPTION; GENE INACTIVATION; GENETIC ENGINEERING; MUTANT; MUTATION; NONHUMAN; PLASMID; STREPTOMYCES; STREPTOMYCES TENEBRARIUS;

ANTI-BACTERIAL AGENTS; BIOSYNTHETIC PATHWAYS; GENE DELETION; GENES, BACTERIAL; GENETIC ENGINEERING; KANAMYCIN; OXIDOREDUCTASES; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES TENEBRARIUS;

EID: 79251600035     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-2908-5     Document Type: Article

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