Biosynthesis of 3′-deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius mutant strain by tacB gene disruption

Journal of Antibiotics

Volumn 61, Issue 2, 2008, Pages 63-69

  Yu, Yonghong ^a   Hou, Xifan ^a   Ni, Xianpu ^a   Xia, Huanzhang ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

3 deoxycarbamoylkanamycin C; 6 dehydrogenase; Complementation; In frame deletion; Streptomyces tenebrarius

Indexed keywords

3' DEOXYCARBAMOYLKANAMYCIN C; ANTIBIOTIC AGENT; APRAMYCIN; BACTERIAL PROTEIN; TOBRAMYCIN; UNCLASSIFIED DRUG; 3' DEOXY CARBAMOYLKANAMYCIN C; 3'-DEOXY-CARBAMOYLKANAMYCIN C; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; DRUG DERIVATIVE; KANAMYCIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG IDENTIFICATION; DRUG PURIFICATION; GENE; GENE CLUSTER; GENE DISRUPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MUTANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES TENEBRARIUS; TACB GENE; CHEMISTRY; GENETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION; NUCLEOTIDE SEQUENCE;

STREPTOMYCES TENEBRARIUS;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; KANAMYCIN; MICROBIAL SENSITIVITY TESTS; READING FRAMES; STREPTOMYCES;

EID: 47049123269     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2008.111     Document Type: Article

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