Synthesis and invitro/invivo Evaluation of the Antitrypanosomal Activity of 3-Bromoacivicin, a Potent CTP Synthetase Inhibitor

ChemMedChem

Volumn 6, Issue 2, 2011, Pages 329-333

  Conti, Paola ^a   Pinto, Andrea ^a   Wong, Pui E ^b   Major, Louise L ^c   Tamborini, Lucia ^a   Iannuzzi, Maria C ^a   DeMicheli, Carlo ^a   Barrett, Michael P ^b   Smith, Terry K ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Amino acids; CTP synthetase; Inhibitors; Transferases; Trypanosoma

Indexed keywords

3 BROMOACIVICIN; ACIVICIN; ANTITRYPANOSOMAL AGENT; LIGASE INHIBITOR; UNCLASSIFIED DRUG; 3-BROMOACIVICIN; CYTIDINE TRIPHOSPHATE SYNTHASE; ENZYME INHIBITOR; ISOXAZOLE DERIVATIVE; LIGASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MAMMAL CELL; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; DRUG ANTAGONISM; SYNTHESIS;

CARBON-NITROGEN LIGASES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ISOXAZOLES;

EID: 79251589619     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000417     Document Type: Article

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