The role of germline promoters and I exons in cytokine-induced gene-specific class switch recombination

Journal of Immunology

Volumn 186, Issue 1, 2011, Pages 350-358

  Dunnick, Wesley A ^a   Shi, Jian ^a   Holden, Victoria ^a,b   Fontaine, Clinton ^a   Collins, John T ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; GAMMA INTERFERON; INTERLEUKIN 4; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CLASS SWITCH RECOMBINATION; CYTOKINE RELEASE; EXON; GAMMA1 HEAVY CHAIN; GAMMA2A HEAVY CHAIN; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; GENE LOCUS; GENE SWITCHING; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; HEAVY CHAIN; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENE;

ANIMALS; CELLS, CULTURED; CHICKENS; CYTOKINES; EXONS; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN SWITCH REGION; IMMUNOGLOBULIN VARIABLE REGION; INTRONS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; RECOMBINATION, GENETIC; TRANSGENES;

EID: 79251582473     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003108     Document Type: Article

References (35)

1. Stavnezer, J. 2000. Molecular processes that regulate class switching. Curr. Top. Microbiol. Immunol. 245: 127-168.
2. Cogne, M., and B. K. Birshtein. 2004. Regulation of class switch recombination. In Molecular Biology of B Cells. T. Honjo, F. W. Alt, and M. S. Neuberger, eds. Academic Press, London, p. 289-305.
3. Bergstedt-Lindqvist, S., P. Sideras, H. R. MacDonald, and E. Severinson. 1984. Regulation of Ig class secretion by soluble products of certain T-cell lines. Immunol. Rev. 78: 25-50.
4. Layton, J. E., E. S. Vitetta, J. W. Uhr, and P. H. Krammer. 1984. Clonal analysis of B cells induced to secrete IgG by T cell-derived lymphokine(s). J. Exp. Med. 160: 1850-1863.
5. Snapper, C. M., and W. E. Paul. 1987. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236: 944-947.
6. Stavnezer-Nordgren, J., and S. Sirlin. 1986. Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. EMBO J. 5: 95-102.
7. Yancopoulos, G. D., R. A. DePinho, K. A. Zimmerman, S. G. Lutzker, N. Rosenberg, and F. W. Alt. 1986. Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. EMBO J. 5: 3259-3266.
8. Jung, S., K. Rajewsky, and A. Radbruch. 1993. Shutdown of class switch recombination by deletion of a switch region control element. Science 259: 984-987.
9. Zhang, J., A. Bottaro, S. Li, V. Stewart, and F. W. Alt. 1993. A selective defect in IgG2b switching as a result of targeted mutation of the I γ 2b promoter and exon. EMBO J. 12: 3529-3537.
10. Seidl, K. J., A. Bottaro, A. Vo, J. Zhang, L. Davidson, and F. W. Alt. 1998. An expressed neo(r) cassette provides required functions of the 1γ2b exon for class switching. Int. Immunol. 10: 1683-1692.
11. Bottaro, A., R. Lansford, L. Xu, J. Zhang, P. Rothman, and F. W. Alt. 1994. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J. 13: 665-674.
12. Qiu, G., G. R. Harriman, and J. Stavnezer. 1999. Ialpha exon-replacement mice synthesize a spliced HPRT-C(a) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice. Int. Immunol. 11: 37-46.
13. Bhattacharya, P., R. Wuerffel, and A. L. Kenter. 2010. Switch region identity plays an important role in Ig class switch recombination. J. Immunol. 184: 6242-6248.
14. Yang, X. W., P. Model, and N. Heintz. 1997. Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome. Nat. Biotechnol. 15: 859-865.
15. Warren, W. D., and M. T. Berton. 1995. Induction of germ-line γ 1 and ε Ig gene expression in murine B cells. IL-4 and the CD40 ligand-CD40 interaction provide distinct but synergistic signals. J. Immunol. 155: 5637-5646.
16. Dunnick, W. A., J. T. Collins, J. Shi, G. Westfield, C. Fontaine, P. Hakimpour, and F. N. Papavasiliou. 2009. Switch recombination and somatic hypermutation are controlled by the heavy chain 39 enhancer region. J. Exp. Med. 206: 2613-2623.
17. Durdik, J., R. M. Gerstein, S. Rath, P. F. Robbins, A. Nisonoff, and E. Selsing. 1989. Isotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic mice. Proc. Natl. Acad. Sci. USA 86: 2346-2350.
18. Lorenz, M., S. Jung, and A. Radbruch. 1995. Switch transcripts in immunoglobulin class switching. Science 267: 1825-1828.
19. Hein, K., M. G. O. Lorenz, G. Siebenkotten, K. Petry, R. Christine, and A. Radbruch. 1998. Processing of switch transcripts is required for targeting of antibody class switch recombination. J. Exp. Med. 188: 2369-2374.
20. Xu, M., and J. Stavnezer. 1990. Structure of germline immunoglobulin heavychain γ 1 transcripts in interleukin 4 treated mouse spleen cells. Dev. Immunol. 1: 11-17.
21. Collins, J. T., and W. A. Dunnick. 1993. Germline transcripts of the murine immunoglobulin γ 2a gene: structure and induction by IFN-γ. Int. Immunol. 5: 885-891.
22. Li, S. C., P. B. Rothman, J. Zhang, C. Chan, D. Hirsh, and F. W. Alt. 1994. Expression of I mu-C γ hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching. Int. Immunol. 6: 491-497.
23. Collins, J. T., J. Shi, B. E. Burrell, D. K. Bishop, and W. A. Dunnick. 2006. Induced expression of murine γ2a by CD40 ligation independently of IFN-γ. J. Immunol. 177: 5414-5419.
24. Chen, Y.-W., C. J. Word, V. Dev, J. W. Uhr, E. S. Vitetta, and P. W. Tucker. 1986. Double isotype production by a neoplastic B cell line. II. Allelically excluded production of mu and γ 1 heavy chains without CH gene rearrangement. J. Exp. Med. 164: 562-579.
25. Shimizu, A., M. C. Nussenzweig, H. Han, M. Sanchez, and T. Honjo. 1991. Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene. J. Exp. Med. 173: 1385-1393.
26. Hasbold, J., J. S. Y. Hong, M. R. Kehry, and P. D. Hodgkin. 1999. Integrating signals from IFN-γ and IL-4 by B cells: positive and negative effects on CD40 ligand-induced proliferation, survival, and division-linked isotype switching to IgG1, IgE, and IgG2a. J. Immunol. 163: 4175-4181.
27. Eccleston, J., C. E. Schrader, K. Yuan, J. Stavnezer, and E. Selsing. 2009. Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats. J. Immunol. 183: 1222-1228.
28. Severinson, E., C. Fernandez, and J. Stavnezer. 1990. Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination. Eur. J. Immunol. 20: 1079-1084.
29. Misaghi, S., C. S. Garris, Y. Sun, A. Nguyen, J. Zhang, A. Sebrell, K. Senger, D. Yan, M. N. Lorenzo, S. Heldens, et al. 2010. Increased targeting of donor switch region and IgE in Sgamma1-deficient B cells. J. Immunol. 185: 166-173.
30. Xu, M. Z., and J. Stavnezer. 1992. Regulation of transcription of immunoglobulin germ-line γ 1 RNA: analysis of the promoter/enhancer. EMBO J. 11: 145-155.
31. Cogné, M., R. Lansford, A. Bottaro, J. Zhang, J. Gorman, F. Young, H.-L. Cheng, and F. W. Alt. 1994. A class switch control region at the 3′ end of the immunoglobulin heavy chain locus. Cell 77: 737-747.
32. Manis, J. P., N. van der Stoep, M. Tian, R. Ferrini, L. Davidson, A. Bottaro, and F. W. Alt. 1998. Class switching in B cells lacking 3′ immunoglobulin heavy chain enhancers. J. Exp. Med. 188: 1421-1431.
33. Seidl, K. J., J. P. Manis, A. Bottaro, J. Zhang, L. Davidson, A. Kisselgof, H. Oettgen, and F. W. Alt. 1999. Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. Proc. Natl. Acad. Sci. USA 96: 3000-3005.
34. Wuerffel, R., L. Wang, F. Grigera, J. Manis, E. Selsing, T. Perlot, F. W. Alt, M. Cogne, E. Pinaud, and A. L. Kenter. 2007. S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity 27: 711-722.
35. Vincent-Fabert, C., R. Fiancette, E. Pinaud, V. Truffinet, N. Cogné, M. Cogné, and Y. Denizot. 2010. Genomic deletion of the whole IgH 3′ regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes. Blood 116: 1895-1898.