High-performance liquid chromatographic determination of memantine hydrochloride in rat plasma using sensitive fluorometric derivatization

Journal of Separation Science

Volumn 34, Issue 3, 2011, Pages 241-246

  Xie, Mei Fen ^a   Zhou, Wei ^a   Tong, Xin Yi ^a   Chen, Yi Le ^a   Cai, Yi ^a   Li, Yan ^a   Duan, Geng Li ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

9 Fluorenylmethyl chloroformate (FMOC Cl); Amantadine hydrochloride; HPLC; Memantine hydrochloride; Pharmacokinetics

Indexed keywords

9-FLUORENYLMETHYL CHLOROFORMATE; AMANTADINE; AMINO GROUP; CHROMATOGRAPHIC DETERMINATION; CHROMATOGRAPHIC SEPARATIONS; CORRELATION COEFFICIENT; DERIVATIZATIONS; FMOC-CL; HPLC; INTERNAL STANDARDS; LIMIT OF QUANTIFICATIONS; LINEAR RANGE; LIQUID CHROMATOGRAPHY-FLUORESCENCE DETECTION; MEMANTINE; MOBILE PHASE; OPTIMAL CONDITIONS; PLASMA PROTEIN; RAT PLASMA; RELATIVE STANDARD DEVIATIONS; RETENTION TIME; VALIDATED METHODS; VORTEX MIXING;

ACETONITRILE; AMINES; CENTRIFUGATION; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; PHARMACOKINETICS; PLASMA (HUMAN);

PLASMAS;

9 FLUORENYLMETHYL CHLOROFORMATE; ACETONITRILE; AMANTADINE; MEMANTINE; PLASMA PROTEIN;

AREA UNDER THE CURVE; ARTICLE; CENTRIFUGATION; CHEMICAL COMPOSITION; CORRELATION COEFFICIENT; DRUG HALF LIFE; FLOW RATE; FLUOROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; RAT; SEPARATION TECHNIQUE; TIME TO MAXIMUM PLASMA CONCENTRATION; WATER FLOW;

ALZHEIMER DISEASE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOPAMINE AGENTS; FLUORENES; HUMANS; MEMANTINE; RATS; RATS, WISTAR;

RATTUS;

EID: 79251569594     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201000579     Document Type: Article

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