Simultaneous determination of amantadine and rimantadine by HPLC in rat plasma with pre-column derivatization and fluorescence detection for pharmacokinetics studies

Biomedical Chromatography

Volumn 19, Issue 9, 2005, Pages 655-662

  Higashi, Yasuhiko ^a   Uemori, Izumi ^a   Fujii, Youichi ^a  

^a HOKURIKU UNIVERSITY   (Japan)

Author keywords

Amantadine; Fluorescent derivatization with o phthalaldehyde and 2 mercaptoethanol; Pharmacokinetic study; Rimantadine

Indexed keywords

AMINES; ANTIVIRAL AGENTS; BIOCHEMISTRY; BODY FLUIDS; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RATS;

2-MERCAPTOETHANOL; AMANTADINE; AMANTADINE HYDROCHLORIDES; FLUORESCENT DERIVATISATION; FLUORESCENT DERIVATIZATION WITH O-PHTHALALDEHYDE AND 2-MERCAPTOETHANOL; O-PHTHALALDEHYDE; PERFORMANCE; PHARMACOKINETIC STUDIES; RIMANTADINE; RIMANTADINE HYDROCHLORIDES;

PHARMACOKINETICS;

AMANTADINE; MERCAPTOETHANOL; PHTHALALDEHYDE; RIMANTADINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DERIVATIZATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG POTENTIATION; DRUG STRUCTURE; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL SIGNIFICANCE; STEADY STATE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALIA;

EID: 28444463998     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.492     Document Type: Article

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