Synthesis and biological screening of 4-(3,3-dimethylspiro{bicyclo[2.2.1] heptan-2,5′-isoxazoline-2}- 3′-yl)-2-aryl-2,3-dihydro-1H-1,5- benzodiazepines

Journal of Heterocyclic Chemistry

Volumn 48, Issue 1, 2011, Pages 144-148

  Naqvi, Tahira ^a   Mahajan, Deepali ^a   Sharma, Rattan Lal ^a   Khan, Inshad Ali ^b   Kapoor, Kamal K ^a  

^a UNIVERSITY OF JAMMU   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

4 [3,3 DIMETHYLSPIRO [BICYCLO[2.2.1]HEPTAN 2,5' ISOXAZOLINE 2] 3'YL] 2 (1,3 ALPHA NAPHTHYL) 2,3 DIHYDRO 1H 1,5 BENZODIAZEPINE; 4 [3,3 DIMETHYLSPIRO [BICYCLO[2.2.1]HEPTAN 2,5' ISOXAZOLINE 2] 3'YL] 2 (1,3 BENZODIOXOLYL) 2,3 DIHYDRO 1H 1,5 BENZODIAZEPINE; 4 [3,3 DIMETHYLSPIRO [BICYCLO[2.2.1]HEPTAN 2,5' ISOXAZOLINE 2] 3'YL] 2 (2 CHLOROPHENYL) 2,3 DIHYDRO 1H 1,5 BENZODIAZEPINE; 4 [3,3 DIMETHYLSPIRO [BICYCLO[2.2.1]HEPTAN 2,5' ISOXAZOLINE 2] 3'YL] 2 (3 BROMOPHENYL) 2,3 DIHYDRO 1H 1,5 BENZODIAZEPINE; 4 [3,3 DIMETHYLSPIRO [BICYCLO[2.2.1]HEPTAN 2,5' ISOXAZOLINE 2] 3'YL] 2 (3 NITROPHENYL) 2,3 DIHYDRO 1H 1,5 BENZODIAZEPINE; 4 [3,3 DIMETHYLSPIRO [BICYCLO[2.2.1]HEPTAN 2,5' ISOXAZOLINE 2] 3'YL] 2 (4 CHLOROPHENYL) 2,3 DIHYDRO 1H 1,5 BENZODIAZEPINE; 4 [3,3 DIMETHYLSPIRO [BICYCLO[2.2.1]HEPTAN 2,5' ISOXAZOLINE 2] 3'YL] 2 (4 METHOXYPHENYL) 2,3 DIHYDRO 1H 1,5 BENZODIAZEPINE; 4 [3,3 DIMETHYLSPIRO [BICYCLO[2.2.1]HEPTAN 2,5' ISOXAZOLINE 2] 3'YL] 2 PHENYL 2,3 DIHYDRO 1H 1,5 BENZODIAZEPINE; BENZODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 79251562205     PISSN: 0022152X     EISSN: 19435193     Source Type: Journal    
DOI: 10.1002/jhet.194     Document Type: Article

References (23)

1. Meunier, B., Acc. Chem Res 2008, 41, 69.
2. (a), Kang, Y. K.,;, Shin, K. J.,;, Yoo, K. H.,;, Seo, K. J.,;, Hong, C. Y.,;, Lee, C. S.,;, Park, S. Y.,;, Kim, D. J.,;, Park, S. W., Bioorg Med Chem Lett 2000, 10, 95
3. (b), Tsubotani, S.,;, Funabashi, Y.,;, Takamoto, M.,;, Hakoda, S.,;, Harada, S., Tetrahedron 1991, 47, 8079.
4. (a), Kochetov, K. N.,;, Sokolov, D. S., Adv Heterocycl Chem 1963, 2, 365
5. (b) In USAN and USP Dictionary of Drug Names;, Griffiths, M. C., Ed; US Pharmacopoeia convention: Rockville, MD, 1982
6. (c), Pathak, D.,;, Jindal, D. P., Asian J Chem 1998, 10, 813
7. (c), Giranda, V. L.,;, Russo, G. R.,;, Felock, P. J.,;, Bailey, T. R.,;, Draper, T.,;, Aldous, D. J.,;, Guiles, J.,;, Dutko, F. J.,;, Diana, G. O.,;, Pevear, D. C., Acta Cryst D 1995, 51, 496.
8. Millan, D. S.,;, Prager, R. H.,;, Brand, C.,;, Hart P. H., Tetrahedron. 2000, 56, 811.
9. (a), Schutz, H., In Benzodiazepines; Springer: Heidelberg, 1982
10. (b), Landquist, J. K., In Comprehensive Heterocyclic Chemistry;, Katritzky, A. R.,;, Rees C. W., Eds. Pergamon: Oxford, 1984; Vol. 1, pp 166
11. (c), Fryer, R. I., In Comprehensive Heterocyclic Chemistry;, Taylor, E. C., Ed.; Wiley: New York, 1991; Vol. 50, Chapter II
12. (d), Randall, L. O.,;, Kappel, B., In Benzodiazepines;, Garattini, S.,;, Musini, E.,;, Randall, L. O., Eds.; Raven Press: New York, 1973; pp 27.
13. McLean, M. J.,;, Macdonald, R. L., J Pharmacol Exp Ther 1988, 244, 789.
14. Ramajayam, R.,;, Giridhar, R.,;, Yadav, M. R.,;, Balaraman, R.,;, Djaballah, H.,;, Shum, D.,;, Radu, C., Eur J Med Chem 2008, 43, 2004; doi: 10.1016/j.ejmech.2007.11.023.
15. (a), Kim, Y. M.,;, Farrah, S.,;, Baney, R. H., Int J Antimicrobial Agents 2007, 29, 217
16. (b), Lien, E. J.,;, Hansch, C.,;, Anderson, S. M., J Med Chem 1968, 11, 430
17. (c), Hunt, W. A., Adv Exp Med Biol 1975, 56, 195.
18. Itoh, K.,;, Sakamaki, H.,;, Nakazato, N.,;, Horiuchi, A.,;, Horn, E.,;, Horiuchi, A. C., Synthesis 2005, 20, 3541.
19. Harwood, L. M.,;, Moody, C. J., In Experimental Organic Chemistry: Primciples and Practice; Blackwell Scientific Publications: Oxford, London, 1989.
20. Ganai, B. A.,;, Kumar, S.,;, Andotra, C. S.,;, Kapoor, K. K., Synth Commun 2006, 36, 803.
21. National committee for Clinical Laboratory Standards. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts: Approved Standard. NCCLS Document M27-A2. National Committee for Clinical laboratory Standards: Wayne, PA, 2002.
22. National committee for Clinical Laboratory Standards. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi: Approved Standard. NCCLS Document M38-A. National Committee for Clinical laboratory Standards: Wayne, PA; 2002.
23. National committee for Clinical Laboratory Standards. Methods for Dilution Antimicrobial Susceptibility Tests for Bacterial that Grow Aerobically: Approved Standard. NCCLS Document M7-A5. National Committee for Clinical laboratory Standards: Wayne, PA; 2000.