Protective effects of CAPE on liver injury induced by CCL4: An electron microscopy study

Ultrastructural Pathology

Volumn 35, Issue 1, 2011, Pages 26-30

  Colakoglu, Neriman ^a   Kus, Ilter ^b   Kukner, Aysel ^c   Pekmez, Hidir ^a   Ozan, Enver ^a   Sarsilmaz, Mustafa ^a  

^a FIRAT UNIVERSITY   (Turkey)

^b BALIKESIR UNIVERSITY   (Turkey)

^c Izzet Baysal University   (Turkey)

Author keywords

Caffeic acid phenethyl ester (CAPE); Carbon tetrachloride; Electron microscopy; Hepatotoxicity; Rat

Indexed keywords

CAFFEIC ACID DERIVATIVE; CAFFEIC ACID PHENETHYL ESTER; CARBON TETRACHLORIDE; DRUG DERIVATIVE; PHENETHYL ALCOHOL;

ANIMAL; ARTICLE; MALE; PATHOLOGY; RAT; TOXIC HEPATITIS; TRANSMISSION ELECTRON MICROSCOPY; WISTAR RAT;

ANIMALS; CAFFEIC ACIDS; CARBON TETRACHLORIDE; DRUG-INDUCED LIVER INJURY; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; PHENYLETHYL ALCOHOL; RATS; RATS, WISTAR;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 79251560308     PISSN: 01913123     EISSN: 15210758     Source Type: Journal    
DOI: 10.3109/01913123.2010.527036     Document Type: Article

References (34)

1. Shi J, Aisaki K, Ikawa Y, Wake K. Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride. Am J Pathol. 1998; 153: 515-525.
2. Hidaka I, Hino K, Korenaga M, et al. Stronger neo-minophagen C, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein. Liver Int. 2007; 27: 845-853.
3. McCay PB, Lai EK, Poyer JL, DuBose CM, Janzen EG. Oxygen- and carbon-centered free radical formation during carbon tetrachloride metabolism: observation of lipid radicals in vivo and in vitro. J Biol Chem. 1984; 259:2135-2143.
4. Taïeb D, Malicet C, Garcia S, et al. Inactivation of stress protein p8 increases murine carbon tetrachloride hepatotoxicity via preserved CYP2E1 activity. Hepatology. 2005; 42: 176-182.
5. Park SW, Lee CH, Kim YS, et al. Protective effect of baicalin against carbon tetrachloride-induced acute hepatic injury in mice. J Pharmacol Sci. 2008; 106: 136-143.
6. Lee KJ, Choi JH, Khanal T, Hwang YP, Chung YC, Jeong HG. Protective effect of caffeic acid phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice. Toxicology. 2008; 248: 18-24.
7. Lee CH, Park SW, Kim YS, et al. Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice. Biol Pharm Bull. 2007; 30: 1898-1904.
8. Madro A, Słomka M, Celiński K, et al. The influence of interferon alpha on the rat liver injured by chronic administration of carbon tetrachloride. Ann Univ Mariae Curie Sklodowska Med. 2002; 57: 55-60.
9. Melhem A, Muhanna N, Bishara A, et al. Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC. J Hepatol. 2006; 45: 60-71.
10. Ates B, Dogru MI, Gul M, et al. Protective role of caffeic acid phenethyl ester in the liver of rats exposed to cold stress. Fundam Clin Pharmacol. 2006; 20: 283-289.
11. Jung WK, Lee DY, Choi YH, et al. Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma. Life Sci. 2008; 82: 797-805.
12. Kudugunti SK, Vad NM, Ekogbo E, Moridani MY. Efficacy of caffeic acid phenethyl ester (CAPE) in skin B16-F0 melanoma tumor bearing C57BL/6 mice. Invest New Drugs. 2009; Oct 21. [Epub ahead of print]
13. Carrasco-Legleu, CE, Sánchez-Pérez Y, Márquez-Rosado L, et al. A single dose of caffeic acid phenethyl ester prevents initiation in a medium-term rat hepatocarcinogenesis model. World J Gastroenterol. 2006; 12: 6779-6785.
14. Carrasco-Legleu CE, Márquez-Rosado L, Fattel-Fazenda S, Arce-Popoca E, Pérez-Carreón JI, Villa-Treviño S. Chemoprotective effect of caffeic acid phenethyl ester on promotion in a medium-term rat hepatocarcinogenesis assay. Int J Cancer. 2004; 108: 488-492.
15. Beltrán-Ramírez O, Alemán-Lazarini L, Salcido-Neyoy M, et al. Evidence that the anticarcinogenic effect of CAPE in the resistant hepatocyte model involves modification of cytochrome P450. Toxicol Sci. 2008; 104: 100-106.
16. Yagmurca M, Erdogan H, Iraz M, Songur A, Ucar M, Fadillioglu E. Caffeic acid phenethyl ester as a protective agent against doxorubicin nephrotoxicity in rats. Clin Chim Acta. 2004; 348: 27-34. (Pubitemid 39208997)
17. Grunberger D, Banerjee R, Eisinger K, et al. Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia. 1988; 44: 230-232.
18. He SX, Luo JY, Wang YP, et al. Effects of extract from Ginkgo biloba on carbon tetrachloride-induced liver injury in rats. World J Gastroenterol. 2006; 12: 3924-3928.
19. Wang CY, Ma FL, Liu JT, Tian JW, Fu FH. Protective effect of salvianic acid a on acute liver injury induced by carbon tetrachloride in rats. Biol Pharm Bull. 2007; 30: 44-47.
20. Feng Y, Lu YW, Xu PH, et al. Caffeic acid phenethyl ester and its related compounds limit the functional alterations of the isolated mouse brain and liver mitochondria submitted to in vitro anoxia-reoxygenation: relationship to their antioxidant activities. Biochim Biophys Acta. 2008; 1780: 659-672.
21. Canbay A, Friedman S, Gores GJ. Apoptosis: the nexus of liver injury and fibrosis. Hepatology. 2004; 39: 273-278.
22. Kaplowitz N. Mechanisms of liver cell injury. J Hepatol. 2000; 32: 39-47.
23. Tomasi A, Albano E, Bani S, et al. Free-radical metabolism of carbon tetrachloride in rat liver mitochondria: a study of the mechanism of activation. Biochem J. 1987; 246: 313-317.
24. Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol. 2003; 33: 105-136.
25. Tang X, Gao J, Wang Y, et al. Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria. J Nutr Biochem. 2006; 17: 177-182.
26. Xu JW, Gong J, Chang XM, et al. Estrogen reduces CCL4-induced liver fibrosis in rats. World J Gastroenterol. 2002; 8: 883-887.
27. Wu XL, Zeng WZ, Wang PL, et al. Effect of compound rhodiola sachalinensis A Bor on CCl4-induced liver fibrosis in rats and its probable molecular mechanisms. World J Gastroenterol. 2003; 9: 1559-1562.
28. Mas N, Tasci I, Comert B, Ocal R, Mas MR. Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fibrosis. World J Gastroenterol. 2008; 14:1108-1111.
29. Yao XX, Jiang SL, Tang YW, Yao DM, Yao X. Efficacy of Chinese medicine Yigankang granule in prophylaxis and treatment of liver fibrosis in rats. World J Gastroenterol. 2005; 11: 2583-2590.
30. Marumoto Y, Terai S, Urata Y, et al. Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver. Biochem Biophys Res Commun. 2008; 367: 546-552.
31. Junnila M, Rahko T, Sukura A, Lindberg LA. Reduction of carbon tetrachloride-induced hepatotoxic effects by oral administration of betaine in male Han-Wistar rats: a morphometric histological study. Vet Pathol. 2000; 37: 231-238.
32. Yildiz Y, Serter M, Ek RO, et al. Protective effects of caffeic acid phenethyl ester on intestinal ischemia-reperfusion injury. Dig Dis Sci. 2009; 54: 738-744.
33. Aladag MA, Turkoz Y, Ozcan, C, et al. Caffeic acid phenethyl ester (CAPE) attenuates cerebral vasospasm after experimental subarachnoidal haemorrhage by increasing brain nitric oxide levels. Int J Dev Neurosci. 2006; 24: 9-14.
34. Altug ME, Serarslan Y, Bal R, et al. Caffeic acid phenethyl ester protects rabbit brains against permanent focal ischemia by antioxidant action: a biochemical and planimetric study. Brain Res. 2008;1201: 135-142.