Effects of exercise on mitochondrial DNA content in skeletal muscle of patients with COPD

Thorax

Volumn 66, Issue 2, 2011, Pages 121-127

  Puente Maestu, Luis ^a,b   Lázaro, Alberto ^a   Tejedor, Alberto ^a   Camaño, Sonia ^a   Fuentes, Marta ^a,b   Cuervo, Miguel ^a   Navarro, Beatriz Oláiz ^c   Agustí, Alvar ^d,e  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

^d HOSPITAL CLÍNIC   (Spain)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; MESSENGER RNA; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE;

AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA CONTENT; EXERCISE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN TISSUE; MUSCLE BIOPSY; OXIDATIVE STRESS; OXYGEN CONSUMPTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE;

EID: 79251558124     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thx.2010.153031     Document Type: Article

References (32)

1. Anon. Skeletal muscle dysfunction in chronic obstructive pulmonary disease. A statement of the American Thoracic Society and European Respiratory Society. Am J Respir Crit Care Med 1999;159:S1-40.
2. Agusti AG, Sauleda J, Miralles C, et al. Skeletal muscle apoptosis and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002;166:485-9.
3. Gosker HR, Hesselink MK, Duimel H, et al. Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD. Eur Respir J 2007;30:73-9.
4. Maltais F, LeBlanc P, Whittom F, et al. Oxidative enzyme activities of the vastus lateralis muscle and the functional status in patients with COPD. Thorax 2000;55:848-53.
5. Rabinovich RA, Bastos R, Ardite E, et al. Mitochondrial dysfunction in COPD patients with low body mass index. Eur Respir J 2007;29:643-50.
6. Remels AH, Schrauwen P, Broekhuizen R, et al. Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD. Eur Respir J 2007;30:245-52. (Pubitemid 47194177)
7. Sauleda J, Garcia-Palmer F, Wiesner RJ, et al. Cytochrome oxidase activity and mitochondrial gene expression in skeletal muscle of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;157:1413-17.
8. Puente-Maestu L, Perez-Parra J, Godoy R, et al. Abnormal mitochondrial function in locomotor and respiratory muscles of COPD patients. Eur Respir J 2009;33:1045-52.
9. Puente-Maestu L, Perez-Parra J, Godoy R, et al. Abnormal transition pore kinetics and cytochrome C release in muscle mitochondria of patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2009;40:746-50.
10. Marcuello A, Gonzalez-Alonso J, Calbet JA, et al. Skeletal muscle mitochondrial DNA content in exercising humans. J Appl Physiol 2005;99:1372-7. (Pubitemid 43014342)
11. Couillard A, Koechlin C, Cristol JP, et al. Evidence of local exercise-induced systemic oxidative stress in chronic obstructive pulmonary disease patients. Eur Respir J 2002;20:1123-9. (Pubitemid 35331868)
12. Mercken EM, Gosker HR, Rutten EP, et al. Systemic and pulmonary oxidative stress after single-leg exercise in COPD. Chest 2009;136:1291-300.
13. van Helvoort HA, Heijdra YF, de Boer RC, et al. Six-minute walking-induced systemic inflammation and oxidative stress in muscle-wasted COPD patients. Chest 2007;131:439-45.
14. Holloszy JO. Regulation by exercise of skeletal muscle content of mitochondria and GLUT4. J Physiol Pharmacol 2008;59(Suppl 7):5-18.
15. Rabe KF, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007;176:532-55.
16. Santos JH, Mandavilli BS, Van HB. Measuring oxidative mtDNA damage and repair using quantitative PCR. Methods Mol Biol 2002;197:159-76.
17. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979;59:527-605.
18. Beauchamp C, Fridovich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 1971;44:276-87.
19. Pilegaard H, Saltin B, Neufer PD. Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle. J Physiol 2003;546:851-8.
20. Gosker HR, Bast A, Haenen GR, et al. Altered antioxidant status in peripheral skeletal muscle of patients with COPD. Respir Med 2005;99:118-25.
21. Puente-Maestu L, Tena T, Trascasa C, et al. Training improves muscle oxidative capacity and oxygenation recovery kinetics in patients with chronic obstructive pulmonary disease. Eur J Appl Physiol 2003;88:580-7.
22. Vina J, Gomez-Cabrera MC, Borras C, et al. Mitochondrial biogenesis in exercise and in ageing. Adv Drug Deliv Rev 2009;61:1369-74.
23. Lin J, Wu H, Tarr PT, et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 2002;418:797-801.
24. Pinho RA, Chiesa D, Mezzomo KM, et al. Oxidative stress in chronic obstructive pulmonary disease patients submitted to a rehabilitation program. Respir Med 2007;101:1830-5.
25. Silveira LR, Pilegaard H, Kusuhara K, et al. The contraction induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1alpha (PGC-1alpha), mitochondrial uncoupling protein 3 (UCP3) and hexokinase II (HKII) in primary rat skeletal muscle cells is dependent on reactive oxygen species. Biochim Biophys Acta 2006;1763:969-76.
26. Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 2000;29:222-30.
27. Giulivi C, Boveris A, Cadenas E. Hydroxyl radical generation during mitochondrial electron transfer and the formation of 8-hydroxydesoxyguanosine in mitochondrial DNA. Arch Biochem Biophys 1995;316:909-16.
28. Richter C, Gogvadze V, Laffranchi R, et al. Oxidants in mitochondria: from physiology to diseases. Biochim Biophys Acta 1995;1271:67-74.
29. Shokolenko I, Venediktova N, Bochkareva A, et al. Oxidative stress induces degradation of mitochondrial DNA. Nucl Acid Res 2009;37:2539-48.
30. Wang H, Hiatt WR, Barstow TJ, et al. Relationships between muscle mitochondrial DNA content, mitochondrial enzyme activity and oxidative capacity in man: alterations with disease. Eur J Appl Physiol Occup Physiol 1999;80:22-7.
31. Mercken EM, Hageman GJ, Langen RC, et al. Decreased exercise-induced expression of NF-κB regulated genes in muscle of COPD patients. Chest Published Online First: 2010 Aug 5. doi:10.1378/chest.10-0275.
32. Robinson MM, Richards JC, Hickey MS, et al. Acute b-adrenergic stimulation does not alter mitochondrial protein synthesis or markers of mitochondrial biogenesis in adult men. Am J Physiol Regul Integr Comp Physiol 2010;298:R25-33.