Effects of vitamin D supplementation on bone density in healthy children: Systematic review and meta-analysis

BMJ

Volumn 342, Issue 7791, 2011, Pages 267-

  Winzenberg, Tania ^a   Powell, Sandi ^b   Shaw, Kelly Anne ^a,c   Jones, Graeme ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b ROYAL HOBART HOSPITAL   (Australia)

^c SOUTHERN CROSS UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

VITAMIN D;

ADOLESCENT; ADULT; BONE DENSITY; BONE MINERAL; CHILD; CHILD HEALTH; DRUG EFFECT; FOREARM; GENETIC HETEROGENEITY; HIP; HUMAN; HUMAN EXPERIMENT; INFANT; LUMBAR SPINE; META ANALYSIS; NORMAL HUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; SPINE; STATISTICAL SIGNIFICANCE; SYSTEMATIC REVIEW; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ADOLESCENT; BIAS (EPIDEMIOLOGY); BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; CHILD; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VITAMIN D;

EID: 79251554369     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.c7254     Document Type: Review

References (59)

1. Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 2006;17:1726-33. (Pubitemid 44607392)
2. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 2007;22:465-75.
3. Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 1996;312:1254-9. (Pubitemid 26147662)
4. Hansen MA, Overgaard K, Riis BJ, Christiansen C. Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 year study. BMJ 1991;303:961-4.
5. Riis BJ, Hansen MA, Jensen AM, Overgaard K, Christiansen C. Low bone mass and fast rate of bone loss at menopause: equal risk factors for future fracture: a 15-year follow-up study. Bone 1996;19:9-12. (Pubitemid 26318738)
6. Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, et al. Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet 1993;341:72-5. (Pubitemid 23028113)
7. Goulding A, Cannan R, Williams SM, Gold EJ, Taylor RW, Lewis-Barned NJ. Bonemineral density in girls with forearm fractures. J Bone Miner Res 1998;13:143-8. (Pubitemid 28063123)
8. Goulding A, Jones IE, Taylor RW, Williams SM, Manning PJ. Bone mineral density and body composition in boys with distal forearm fractures: a dual-energy x-ray absorptiometry study. J Pediatr 2001;139:509-15. (Pubitemid 32977264)
9. Ma D, Jones G. The association between bone mineral density, metacarpal morphometry, and upper limb fractures in children: a population-based case-control study. J Clin EndocrinolMetab 2003;88:1486-91.
10. Osteoporosis prevention, diagnosis and therapy. NIH Consensus Statement 2000;17:1-45.
11. Munns C, ZacharinMR, Rodda CP, Batch JA, Morley R, CranswickNE, et al. Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement. Med J Aust 2006;185:268-72.
12. Holick MF. Vitamin D deficiency. N Engl JMed 2007;357:266-81.
13. Das G, Crocombe S, McGrath M, Berry JL, Mughal MZ. Hypovitaminosis D among healthy adolescent girls attending an inner city school. Arch Dis Child 2006;91:569-72.
14. Sharma S, Khan N, Khadri A, Julies P, Gnanasambandam S, Saroey S, et al. Vitamin D in pregnancy - time for action: a paediatric audit. BJOG 2009;116:1678-82.
15. Zamora SA, Rizzoli R, Belli DC, Slosman DO, Bonjour JP. Vitamin D supplementation during infancy is associated with higher bone mineral mass in prepubertal girls. J Clin Endocrinol Metab 1999;84:4541-4.
16. Guillemant J, Le HT, Maria A, Allemandou A, Peres G, Guillemant S. Wintertime vitamin D deficiency in male adolescents: effect on parathyroid function and response to vitamin D3 supplements. Osteoporos Int 2001;12:875-9.
17. Outila TA, Karkkainen MU, Lamberg-Allardt CJ. Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bonemineral density. Am J Clin Nutr 2001;74:206-10.
18. Lehtonen-Veromaa MK, Mottonen TT, Nuotio IO, Irjala KM, Leino AE, Viikari JS. Vitamin D and attainment of peak bone mass among peripubertal Finnish girls: a 3-y prospective study. Am J Clin Nutr 2002;76:1446-53.
19. Cheng S, Tylavsky F, Kroger H, Karkkainen M, Lyytikainen A, Koistinen A, et al. Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls. Am J Clin Nutr 2003;78:485-92.
20. Tylavsky FA, Cheng S, Lyytikainen A, Viljakainen H, Lamberg-Allardt C. Strategies to improve vitaminDstatus in northern European children: exploring themerits of vitamin D fortification and supplementation. J Nutr 2006;136:1130-4.
21. Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR. Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone 2002;30:771-7.
22. El-Hajj Fuleihan G, Nabulsi M, Choucair M, Salamoun M, Hajj Shahine C, Kizirian A, et al. Hypovitaminosis D in healthy schoolchildren. Pediatrics 2001;107:E53.
23. Jones G, Blizzard C, Riley MD, Parameswaran V, Greenaway TM, Dwyer T. Vitamin D levels in prepubertal children in southern Tasmania: prevalence and determinants. Eur J Clin Nutr 1999;53:824-9.
24. Jones G, Dwyer T, Hynes KL, Parameswaran V, Greenaway TM. Vitamin D insufficiency in adolescent males in southern Tasmania: prevalence, determinants, and relationship to bone turnover markers. Osteoporos Int 2005;16:636-41.
25. Rockell JE, Green TJ, Skeaff CM, Whiting SJ, Taylor RW, Williams SM, et al. Season and ethnicity are determinants of serum 25- hydroxyvitamin D concentrations in New Zealand children aged 5-14 y. J Nutr 2005;135:2602-8.
26. Rockell JE, Skeaff CM, Williams SM, Green TJ. Serum 25- hydroxyvitamin D concentrations of New Zealanders aged 15 years and older. Osteoporos Int 2006;17:1382-9.
27. Cheng S, Lyytikainen A, Kroger H, Lamberg-Allardt C, Alen M, Koistinen A, et al. Effects of calcium, dairy product, and vitamin D supplementation on bonemass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial. Am J Clin Nutr 2005;82:1115-26, quiz 1147-8.
28. Jones G, Dwyer T. Bone mass in prepubertal children: gender differences and the role of physical activity and sunlight exposure. J Clin Endocrinol Metab 1998;83:4274-9. (Pubitemid 29100121)
29. Lehtonen-Veromaa M, Mottonen T, Irjala K, Karkkainen M, Lamberg-Allardt C, Hakola P, et al. Vitamin D intake is low and hypovitaminosis D common in healthy 9- to 15-year-old Finnish girls. Eur J Clin Nutr 1999;53:746-51. (Pubitemid 29424006)
30. Ala-Houhala M, Koskinen T, Koskinen M, Visakorpi JK. Double blind study on the need for vitamin D supplementation in prepubertal children. Acta Paediatr Scand 1988;77:89-93. (Pubitemid 18081550)
31. El-Hajj Fuleihan G, Nabulsi M, Tamim H, Maalouf J, Salamoun M, Choucair M, et al. Impact of vitamin D supplementation on musculoskeletal parameters in adolescents: a randomised trial. J Bone Miner Res 2004;19(suppl 1):S13.
32. Du X, Zhu K, Trube A, Zhang Q,Ma G, Hu X, et al. School-milk intervention trial enhances growth and bone mineral accretion in Chinese girls aged 10-12 years in Beijing. Br J Nutr 2004;92:159-68. (Pubitemid 38961284)
33. El-Hajj Fuleihan G, Nabulsi M, Tamim H, Maalouf J, Salamoun M, Khalife H, et al. Effect of vitamin D replacement on musculoskeletal parameters in school children: a randomized controlled trial. J Clin Endocrinol Metab 2006;91:405-12. (Pubitemid 43236902)
34. Viljakainen HT, Natri AM, Karkkainen M, Huttunen MM, Palssa A, Jakobsen J, et al. A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention. J Bone Miner Res 2006;21:836-44.
35. Winzenberg TM, Powell S, Shaw KA, Jones G. Vitamin D supplementation for improving bone mineral density in children. (Protocol.) Cochrane Database Syst Rev 2008;1:CD006944.
36. Gilsanz V. Bone density in children: a review of the available techniques and indications. Eur J Radiol 1998;26:177-82.
37. Marin F, Gonzalez-Macias J, Diez-Perez A, Palma S, Delgado-Rodriguez M. Relationship between bone quantitative ultrasound and fractures: a meta-analysis. J Bone Miner Res 2006;21:1126-35. (Pubitemid 43962842)
38. Alderson P, Green S. Additional module 1: meta-analysis of continuous data. Cochrane Collaboration, 2002.
39. Winzenberg T, Shaw K, Fryer J, Jones G. Effects of calcium supplementation on bone density in healthy children:meta-analysis of randomised controlled trials. BMJ 2006;333:775.
40. Winzenberg TM, Shaw K, Fryer J, Jones G. Calcium supplementation for improving bone mineral density in children. Cochrane Database Syst Rev 2006;2:CD005119.
41. Du X, Zhu K, Trube A, Fraser DR, Greenfield AH, Zhang Q, et al. Effects of school-milk intervention on growth and bone mineral accretion in Chinese girls aged 10-12 years: accounting for cluster randomisation. Br J Nutr 2005;94:1038-9. (Pubitemid 43092439)
42. Calvo MS. Dietary considerations to prevent loss of bone and renal function. Nutrition 2000;16:564-6.
43. Clutterbuck J. The prevention and treatment of osteoporosis - part (i) of (ii). Int J Alternat Complement Med 1995;13:19-22.
44. Compston J. Vitamin D helps stem bone loss. Nurs Times 1998;94:47.
45. Flynn A. The role of dietary calcium in bone health. Proc Nutr Soc 2003;62:851-8. (Pubitemid 38004982)
46. Fehily AM, Coles RJ, Evans WD, Elwood PC. Factors affecting bone density in young adults. Am J Clin Nutr 1992;56:579-86.
47. MatsumotoT, KuboderaN. ED-71, a newactivevitaminD3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects. J Steroid Biochem Mol Biol 2007;103:584-6.
48. Venkataraman PS, Luhar H, Neylan MJ. Bone mineral metabolism in full-term infants fed human milk, cow milk-based, and soy-based formulas. Am J Dis Child 1992;146:1302-5.
49. Duhamel JF, Zeghoud F, Sempe M, Boudailliez B, Odievre M, Laurans M, et al. [Prevention of vitamin D deficiency in adolescents and pre-adolescents. An interventional multicenter study on the biological effect of repeated doses of 100,000 IU of vitamin D3.] Arch Pediatr 2000;7:148-53.
50. Ho ML, Yen HC, Tsang RC. Randomized study of sunshine exposure and serum 25-OHD in breast-fed infants in Beijing, China. J Pediatr 1985;107:928-31.
51. Feliciano ES, Ho ML, Specker BL, Falciglia G, Shui QM, Yin TA, et al. Seasonal and geographical variations in the growth rate of infants in China receiving increasing dosages of vitamin D supplements. J Trop Pediatr 1994;40:162-5. (Pubitemid 24200609)
52. Andersen R, Molgaard C, Skovgaard LT, Brot C, Cashman KD, Jakobsen J, et al. Effect of vitamin D supplementation on bone and vitamin D status among Pakistani immigrants in Denmark: a randomised double-blinded placebo-controlled intervention study. Br J Nutr 2008;100:197-207.
53. Winzenberg TM, Powell S, Shaw KA, Jones G. Vitamin D supplementation for improving bone mineral density in children. Cochrane Database Syst Rev 2010;10:CD006944.
54. El-Hajj Fuleihan G, Vieth R. Vitamin D insufficiency and musculoskeletal health in children and adolescents. In: Burckhardt P, Heaney R, Dawson-Hughes B, eds. Nutritional aspects of osteoporosis 2006, proceedings of the international symposium on nutritional aspects of osteoporosis, 4-6 May 2006, Lausanne, Switzerland. Elsevier, 2007.
55. Zhu K, ZhangQ, Foo LH, Trube A, Ma G,Hu X, et al. Growth, bone mass, and vitamin D status of Chinese adolescent girls 3 y after withdrawal of milk supplementation.AmJ Clin Nutr 2006;83:714-21.
56. Cranney A, Horsley T,O'Donnell S, Weiler H, Puil L, OoiD, et al. Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep) 2007,158:1-235.
57. Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ. Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med 2004;158:531-7.
58. Prentice A, Parsons TJ, Cole TJ. Uncritical use of bonemineral density in absorptiometry may lead to size-related artifacts in the identification of bone mineral determinants. Am J Clin Nutr 1994;60:837-42.
59. Cohen J. Statistical power analysis for the behavorial sciences. Lawrence Erlbaum, 1988.