Colonic soluble mediators from the maternal separation model of irritable bowel syndrome activate submucosal neurons via an interleukin-6-dependent mechanism

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 300, Issue 2, 2011, Pages

  O'Malley, Dervla ^a   Liston, Martin ^a   Hyland, Niall P ^a,b   Dinan, Timothy G ^a,b   Cryan, John F ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Cholinergic receptor; Mitogen activated protein kinase; Signal transducer and activator of transcription 3; Supernatant

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MUSCARINIC RECEPTOR; NICOTINIC RECEPTOR; STAT PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL PAIN; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA RHYTHM; CLINICAL ASSESSMENT; CLINICAL FEATURE; CLINICAL STUDY; COLON BIOPSY; COLON SECRETION; DEFECATION HABIT; DIGESTIVE SYSTEM FUNCTION DISORDER; FEMALE; GASTROINTESTINAL TRACT FUNCTION; GEOGRAPHIC INFORMATION SYSTEM; GLIA CELL; INTESTINE; ION TRANSPORT; IRRITABLE COLON; MALE; MEDIATOR RELEASE; MULTIPLE SCLEROSIS; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; SUBMUCOSA;

ACETYLCHOLINE; ANIMALS; CHOLINERGIC AGONISTS; COLON; FEMALE; GANGLIA; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; IRRITABLE BOWEL SYNDROME; MALE; MATERNAL DEPRIVATION; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERLEUKIN-6; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUBMUCOUS PLEXUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79251553738     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00385.2010     Document Type: Article

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