Glutaredoxin and thioredoxin can be involved in producing the pharmacologically active metabolite of a thienopyridine antiplatelet agent, prasugrel

Drug Metabolism and Disposition

Volumn 39, Issue 2, 2011, Pages 208-214

  Hagihara, Katsunobu ^a   Kazui, Miho ^a   Kurihara, Atsushi ^a   Kubota, Kazuishi ^a   Ikeda, Toshihiko ^b  

^a DAIICHI SANKYO CO   (Japan)

^b YOKOHAMA COLLEGE OF PHARMACY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 2 CYCLOPROPYL 1 (2 FLUOROPHENYL) 2 OXOETHYL] 4 MERCAPTO 3 PIPERIDINYLIDENE]ACETIC ACID; 2 [2 OXO 6,7 DIHYDROTHIENO[3,2 C]PYRIDIN 5(4H) YL] 1 CYCLOPROPYL 2 (2 FLUOROPHENYL)ETHANONE; DRUG METABOLITE; GLUTAREDOXIN; PRASUGREL; THIOREDOXIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG OXIDATION; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME ACTIVITY; GEL FILTRATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CYTOSOL; LIVER MICROSOME; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; BIOTRANSFORMATION; BLOTTING, WESTERN; CHROMATOGRAPHY, GEL; CYTOSOL; GLUTAREDOXINS; GLUTATHIONE; HUMANS; LIVER; MICROSOMES, LIVER; PIPERAZINES; PLATELET AGGREGATION INHIBITORS; TANDEM MASS SPECTROMETRY; THIOPHENES; THIOREDOXINS;

EID: 79251528235     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.035196     Document Type: Article

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