Proteinuria induced by parenteral iron in chronic kidney disease - A comparative randomized controlled trial

Clinical Journal of the American Society of Nephrology

Volumn 6, Issue 1, 2011, Pages 114-121

  Agarwal, Rajiv ^a,b   Leehey, David J ^b,c   Olsen, Scott M ^d   Dahl, Naomi V ^d  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

^d Watson Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FERRIC GLUCONATE; FERRIC HYDROXIDE SUCROSE; PROTEIN;

ADULT; AGED; ARTICLE; CHRONIC KIDNEY DISEASE; CREATININE URINE LEVEL; FEMALE; HUMAN; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PROTEIN URINE LEVEL; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; TREATMENT DURATION;

ADULT; AGED; ALBUMINURIA; ANEMIA, IRON-DEFICIENCY; ANGIOTENSIN RECEPTOR ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CHRONIC DISEASE; CREATININE; FEMALE; FERRIC COMPOUNDS; HUMANS; KIDNEY DISEASES; MALE; MIDDLE AGED; PROTEINURIA;

EID: 79251523888     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.06020710     Document Type: Article

References (21)

1. Elliott J, Mishler D, Agarwal R: Hyporesponsiveness to erythropoietin: Causes and management. Adv Chronic Kidney Dis 16: 94-100, 2009
2. KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease. Am J Kidney Dis 47: S11-S145, 2006
3. Locatelli F, Nissenson AR, Barrett BJ, Walker RG, Wheeler DC, Eckardt KU, Lameire NH, Eknoyan G: Clinical practice guidelines for anemia in chronic kidney disease: Problems and solutions. A position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 74: 1237-1240, 2008
4. Van Wyck DB, Roppolo M, Martinez CO, Mazey RM, McMurray S: A randomized, controlled trial comparing IV iron sucrose to oral iron in anemic patients with nondialysis-dependent CKD. Kidney Int 68: 2846-2856, 2005
5. Fishbane S: Iron management in nondialysis-dependent CKD. Am J Kidney Dis 49: 736-743, 2007
6. Agarwal R: Iron, oxidative stress, and clinical outcomes. Pediatr Nephrol 23: 1195-1198, 2008
7. Horl WH: Iron therapy for renal anemia: how much needed, how much harmful? Pediatr Nephrol 22: 480-489, 2007
8. Coyne DW, Adkinson NF, Nissenson AR, Fishbane S, Agarwal R, Eschbach JW, Michael B, Folkert V, Batlle D, Trout JR, Dahl N, Myirski P, Strobos J, Warnock DG: Sodium ferric gluconate complex in hemodialysis patients. II. Adverse reactions in iron dextran-sensitive and dextran-tolerant patients. Kidney Int 63: 217-224, 2003
9. Michael B, Fishbane S, Coyne DW, Agarwal R, Warnock DG: Drug insight: Safety of intravenous iron supplementation with sodium ferric gluconate complex. Nat Clin Pract Nephrol 2: 92-100, 2006
10. Zager RA, Johnson AC, Hanson SY: Parenteral iron nephrotoxicity: Potential mechanisms and consequences. Kidney Int 66: 144-156, 2004
11. Agarwal R, Vasavada N, Sachs NG, Chase S: Oxidative stress and renal injury with intravenous iron in patients with chronic kidney disease. Kidney Int 65: 2279-2289, 2004
12. Leehey DJ, Palubiak DJ, Chebrolu S, Agarwal R: Sodium ferric gluconate causes oxidative stress but not acute renal injury in patients with chronic kidney disease: A pilot study. Nephrol Dial Transplant 20: 135-140, 2005
13. Agarwal R, Rizkala AR, Kaskas MO, Minasian R, Trout JR: Iron sucrose causes greater proteinuria than ferric gluconate in non-dialysis chronic kidney disease. Kidney Int 72: 638-642, 2007
14. Holden JE, Kelley K, Agarwal R: Analyzing change: A primer on multilevel models with applications to nephrology. Am J Nephrol 28: 792-801, 2008
15. Agarwal R: Ironing out the mystery of nephrotoxicity of parenteral iron. J Lab Clin Med 146: 5-6, 2005
16. Agarwal R, Warnock D: Issues related to iron replacement in chronic kidney disease. Semin Nephrol 22: 479-487, 2002
17. Agarwal R: On the nature of proteinuria with acute renal injury in patients with chronic kidney disease. Am J Physiol Renal Physiol 288: F265-F271, 2005
18. Agarwal R: Reproducibility of renal function measurements in adult men with diabetic nephropathy: Research and clinical implications. Am J Nephrol 27: 92-100, 2007
19. Zager RA, Johnson AC, Hanson SY, Wasse H: Parenteral iron formulations: A comparative toxicologic analysis and mechanisms of cell injury. Am J Kidney Dis 40: 90-103, 2002
20. Zager RA: Parenteral iron treatment induces MCP-1 accumulation in plasma, normal kidneys, and in experimental nephropathy. Kidney Int 68: 1533-1542, 2005
21. Agarwal R: Proinflammatory effects of iron sucrose in chronic kidney disease. Kidney Int 69: 1259-1263, 2006