Comparative microstructures and cytotoxicity assays for ballistic aerosols composed of micrometals and nanometals: Respiratory health implications

International Journal of Nanomedicine

Volumn 6, Issue 1, 2011, Pages 167-178

  Machado, Brenda I ^a   Suro, Raquel M ^a   Garza, Kristine M ^a   Murr, Lawrence E ^a  

^a UNIVERSITY OF TEXAS AT EL PASO   (United States)

Author keywords

Analysis; Ballistic penetration; Cytotoxicity assays; Metal aerosols; Microchemical; Micron nanoparticulate analysis; Microstructure

Indexed keywords

COBALT; IRON; METAL NANOPARTICLE; MICROMETAL; NICKEL; TUNGSTEN; UNCLASSIFIED DRUG;

AEROSOL; ARTICLE; BALLISTIC AEROSOL; CELL VIABILITY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTALLIZATION; CYTOTOXICITY; HUMAN; HUMAN CELL; MORPHOLOGY; NANOTECHNOLOGY; PARTICLE SIZE; RESPIRATORY TRACT DISEASE; SCANNING ELECTRON MICROSCOPY; STRUCTURE ANALYSIS; THROMBOCYTE AGGREGATION;

AEROSOLS; CELL LINE; CELL SURVIVAL; COBALT; FORENSIC BALLISTICS; HUMANS; IRON; METAL NANOPARTICLES; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; NANOMEDICINE; NICKEL; PARTICLE SIZE; RESPIRATORY SYSTEM; TUNGSTEN;

EID: 79251517070     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S15537     Document Type: Article

References (15)

1. Donaldson K, Stone V, Clouter A, et al. Ultrafine particles. Occup Environ Med. 2001;58(3):211-215.
2. Murr LE, Soto KF, Garza KM. Health hazards of manufactured, natural environmental and anthropogenic atmospheric nanoparticulate materials: Past, present and future. In: Ali N, Ahmed W, Oechsner A, editors. Biomaterial and Biomedical Engineering. Zurich, Switzerland: Trans Tech Publishers; 2008.
3. Pope CA IIIrd, Dockery DW. Health effects of fine particulate pollution: Lines that connect. J Air Waste Manag Assoc. 2006;56(10):709-742.
4. Soto KF, Garza KM, Shi Y, Murr LE. Direct contact cytotoxicity assays for filter-collected, carbonaceous (dust) nanoparticulate. Material and observations of lung cell response. Atmos Environ. 2008;42: 1970-1982.
5. Oberdörster G. Pulmonary effects of inhaled ultrafine particles. Int Arch Occupat Environ Health. 2001;74(1):1-8.
6. Machado BI, Murr LE, Suro RM. Characterization and cytotoxic assessment of ballistic aerosol particulates for tungsten alloy penetrators into steel target plates. Int J Environ Res Public Health. 2010;7(9): 3313-3331.
7. Guilmette RA, Parkhurst MA, Miller G, et al. Human Health Risk Assessment of Capstone Depleted Uranium Aerosols. Attachment 3 of Depleted Uranium Aerosol Doses and Risk: Summary of US Assessments. Columbus, OH: Battelle Press; 2006.
8. Gold K, Cheng TD, Holmes A. A quantitative analysis of aerosols inside an armored vehicle perforated by a kinetic energy penetrator containing tungsten, nickel and cobalt. Mil Med. 2007;172(4):393-398.
9. Pizaña C, et al. Solid-state flow, mechanical alloying, and melt-related phenomena for [001] single-crystal W ballistic rod penetrators interacting with steel targets. Mater Sci Eng A. 2006;428:301-313.
10. Murr LE, Pizaña C. Dynamic Recrystallization: The dynamic deformation regime. Metallurgical and Materials Transactions A. 2008; 38(11):2611-2628.
11. Garza KM, Soto KF, Murr LE. Cytotoxicity and reactive oxygen species generation from aggregated carbon and carbonaceous nanoparticulate materials. Int J Nanomed. 2008;3(1):83-94.
12. Oberdörster G, Ferin J, Lehnert BE. Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect. 1994;102(Suppl 5):173-179.
13. Buzea C, Pacheco J, Robbie K. Nanomaterials and nanoparticles: Sources and toxicity. Biointerphases. 2007;2(4):17-71.
14. Dobravolvkala MA, McNeil SE. Immunological properties of engineered nanomaterials. Nat Nanotechnol. 2007;2(8):469-478.
15. Kennedy C, Murr L.E. Comparison of tungsten heavy-alloy rod penetration into ductile and hard metal targets: Microstructural analysis and computer simulations. Mater. Sci. Eng. 2002; 325:131-143.