Characterization and cytotoxic assessment of ballistic aerosol particulates for tungsten alloy penetrators into steel target plates

International Journal of Environmental Research and Public Health

Volumn 7, Issue 9, 2010, Pages 3313-3331

  Machado, Brenda I ^a   Murr, Lawrence E ^a   Suro, Raquel M ^a   Gaytan, Sara M ^a   Ramirez, Diana A ^a   Garza, Kristine M ^a   Schuster, Brian E ^b  

^a UNIVERSITY OF TEXAS AT EL PASO   (United States)

^b U S ARMY RESEARCH LABORATORY   (United States)

Author keywords

Aerosol; Ballistic penetration; Cytotoxic assays; Nanoparticulates; Scanning and transmission electron microscopy; Tungsten alloys

Indexed keywords

ALLOY; COBALT; COPPER; INTERLEUKIN 6; INTERLEUKIN 8; IRON; NANOPARTICLE; NICKEL; TUNGSTEN;

AEROSOL; APOPTOSIS; ARTICLE; BALLISTICS; CELL VIABILITY; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMAGE QUALITY; LUNG ALVEOLUS EPITHELIUM; LUNG PARENCHYMA; MOLECULAR WEIGHT; OXIDATIVE STRESS; PARTICULATE MATTER; SCANNING ELECTRON MICROSCOPE; TOXIC INHALATION; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

EID: 78649605873     PISSN: None     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph7093313     Document Type: Article

References (30)

1. Gold, K.; Cheng, Y.S.; Holmes T.D. A quantitative analysis of aerosols inside an armored vehicle perforated by a kinetic energy penetrator containing tungsten, nickel, and cobalt. Military Med. 2007, 172, 393-398.
2. Guilmette, R.A.; Parkhurst, M.A.; Miller, G.; Daxon, E.G.; Lodde, G.M.; Roszell, L.E.; Falo, G.A.; Szrom, F. Human Health Risk Assessment of Capstone Depleted Uranium Aerosols: Attachment 3 of Depleted Uranium Aerosol Doses and Risk: Summary of U.S. Assessments; Battelle Press: Columbus, OH, USA, 2006.
3. Donaldson, K.; Stone, V.; Clouter, A.; Renwick, L.; Mac Nee, W. Ultrafine Particles. Occupat. Eviron. Med. 2001, 58, 211-216.
4. Oberdörster, G. Pulmonary effects of inhaled ultrafine particles. Int. Arch. Occupat. Environ. Health 2001, 74, 1-8.
5. Pope, C.A., III; Dockery, D.W. Health effects of fine particulate air pollution: lines that connect. J. Air Waste Manag. Assoc. 2006, 56, 709-742.
6. Soto, K.F.; Carrasco, A.; Powell, T.G.; Garza, K.M.; Murr, L.E. Comparison in vitro cytotoxicity assessment of some manufactured nanoparticulate materials characterized by transmission electron microscopy. J. Nanopart. Res. 2005, 7, 145-169.
7. Murr, L.E.; Soto, K.F.; Garza, K.M. Health Hazards of Manufactured, Natural Environmental and Anthropogenic Atmospheric Nanoparticulate Materials: Past, Present and Future. In Biomaterial and Biomedical Engineering; Ahmed, W., Ali, N., Öchsner, A., Eds.; Trans Tech Publishers: Zurich, Switzerland, 2008; pp. 1-54.
8. Soto, K.F.; Garza, K.M.; Shi, Y.; Murr, L.E. Direct contact cytotoxicity arrays for filter-collected, carbonaceous (dust) nanoparticulate material and observations of lung cell response. Atmos. Environ. 2008, 42, 1970-1982.
9. Murr, L.E. Microstructures and Nanostructures for Environmental Carbon Nanotubes and Nanoparticulate Soots. Int. J. Environ. Res. Public Health. 2008, 5, 321-336.
10. Murr, L.E.; Garza, K.M. Natural and Anthropogenic Environmental Nanoparticulates: Their Microstructural Characterization and Respiratory Health Implications. Atmos. Environ. 2009, 43, 2683-2692.
11. German, R.M. Liquid Phase Sintering; Plenum Press: New York, NY, USA, 1985; p. 251.
12. Roth, J.F.; Watchell, G.P. Heat transfer and chemical kinetics in the ignition of solid propellants. Ind. Eng. Chem. Fundamen. 1962, 1, 62-67.
13. Gold, K. Analysis of Aerosols Produced During Tests of Tungsten Alloy Kinetic Energy Penetrators; Technical Report ARWEC-TR-97014, US Army Armament Research; Development and Engineering Center: Picatinny Arsenal, NJ, USA, 1997.
14. Hetland, R.B.; Refsnes, M.; Myran, T.; Johansen, B.V.; Uthus, N.; Schwarts, P.E. Mineral and/or metal content as critical determinants of particle-induced release of IL-6 and IL-8 from A549 cells. J. Toxicol. Environ. Health A 2000, 60, 47-65.
15. Hetland, R.B.; Casser, F.R.; Refsnes, M.; Schwarts, P.E.; Lag, M.; Boere, A.F.G.; Dybing, E. Release of inflammatory cytokines, cell toxicity and apoptosis in epithelial lung cells after exposure to ambient air particles of different size fractions. Toxicol. In Vitro 2004, 18, 203-212.
16. Nelson, S.I.; Martin, T.R. Cytokines in Pulmonary Disease: Infection and Inflammation Lung Biology in Health and Disease; Marcel Dekker Inc.: New York, NY, USA, 2000.
17. Van Eeden, S.F.; Tan, W.C.; Suwa, T.; Fujji, T. Cytokines involved in systemic inflammatory response induced by exposure to particulate matter air pollutants (PM10). Amer. J. Respir. Crit. Care Med. 2001, 164, 826-830.
18. Chung, K.F. Cytokines in chronic obstructive pulmonary disease. Environ. Respir. J. 2001, 18, 505-595.
19. Inflammatory Mechanisms in Asthma; Holgate, S.T., Busse, W.W., Eds.; Marcel Dekker Inc.: New York, NY, USA, 1998.
20. Asthma and COPD; Barnes, P.; Drazen, J.; Rennard, S.; Thomson, N., Eds.; Academic Press: New York, NY, USA, 2008.
21. Soto, K.F.; Garza, K.M.; Murr, L.E. Cytotoxic effects of aggregated nanomaterials. Acta Biomater. 2007, 3, 351-358.
22. Cugell, D.W.; Morgan, W.K.C.; Perkins, A. The respiratory Effects of Cobalt. Arch. Internal Med. 1990, 150, 177-183.
23. Clinical Environmental Health and Toxic Exposure, 2nd ed.; Sullivan, S.B., Kviezar, C.R., Eds.; Lippincott Williams & Wilkins: Philadelphia, PA, USA, 2001.
24. Buzea C.; Pacheco, J.; Robbie, K. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2007, 2, 17-71.
25. Murr, L.E.; Soto, K.F.; Garza, K.M. Health Hazards of Manufactured, Natural Environmental and other Anthropogenic Atmospheric Nanoparticulate Materials: Past, Present and Future. In Biomaterials and Biomedical Engineering; Ahmed, W., Ali, N., Öchsner, A., Eds.; Trans. Tech Publishing: Zurich, Switzerland, 2008; pp. 1-55.
26. Oberdörster, G.; Ferin, J.; Lehnert, B.E.; Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect. 1994, 102, 173-179.
27. Dobravolvkala, M.A.; McNeil, S.E. Immunological properties of engineered nanomaterials. Nat. Nanotechnol. 2007, 2, 469-478.
28. Sonavane, G.; Tomoda, K.; Makino. Biodistribution of Colloidal Gold Nanoparticles after Intravenous Administration: Effect of Particle Size. Colloid Surface B 2008, 66, 274-280.
29. Borm, P.J.; Robbins, D.; Haubols, S. The potential risks of nanomaterials: A review carried out for ECETOC. Part. Fibre Toxicol. 2006, 3, 11-20.
30. Shi, Y.; Murr, L.E.; Soto, K.F.; Lee, W-Y; Guerrero, P.A.; Ramirez, D.A. Characterization and comparison of speciated atmospheric carbonaceous particulates and their polycyclic aromatic hydrocarbon contents in the context of the Paso del Norte airshed along the U.S.-Mexico Border. Polycyc. Aromatic Comp. 2007, 27, 361-400.